"Yellow Poison" has become an epidemic: Internet literature needs to be supervised urgently.

  Massive information, instant interaction, free access … Nowadays, online reading has become the first reading choice for many young people, and it has the potential to replace traditional reading. However, the lack of supervision and mixed quality are the fatal wounds of online reading materials, and the proliferation of "pornography" is an epidemic of online literature in China.


  Pornographic novels are on the list.


  Yesterday, the reporter saw a reading list on the "Reading" channel of the famous domestic portal "Sohu", showing the most popular works on this website, many of which are original works on the Internet. This ranking is divided into more than ten categories, such as novels, biographies, youth campus and urban romance. Surprisingly, a large number of pornographic novels with naked titles are among them, and the categories of youth campus, urban romance, fantasy and chivalry and chivalry have become the hardest hit areas. Taking "Youth Campus" as an example, the novels on the list are Sexual Desire-Erupting Campus, Mafia Students, Men’s Desire for Color Campus, Diary of the Growth of a Lost Boy, and Spirit and Body in Prostitution. "Fantasy" is also the word "color", and the works on the list include Chronicle of Affair, The Best Rogue of the Millennium, The Best Rogue of Color, The Demon Wife’s Charming Concubine, The Demon Desire, and so on. In the "urban romance", it is full of cheating, incest and other themes, such as "Widow Spring: I and Widow Landlord" and "Damn temptation-starting with my mother-in-law! "Go to bed nanny" and so on.


  Shocking content is obscene


  Not only are the titles of these works shocking, but when you click in, the reporter finds that their contents are completely qualified to be obscene. The brief introduction of "Sexual Desire-Erosion Campus" is: "A young child’s decadent career in college is entangled with different women, and his classmates and teachers … are entangled in bed and are caught in sexual desire." "The Romance History of the Principal" says: "Zhang Bin, the principal of a middle school, did not hesitate to let his wife put a green hat on him in order to become the principal, and then when Zhang Bin, the principal, faced one woman after another, he got lost in the rolling world of mortals, and he had sex with more and more women, and then he became more and more vicious …" In addition to pornography and obscenity, some novels also took the opportunity to promote decadent outlook on life, such as "keyboard" by the author of "Forgetting the City" Whether it’s playing flowers or wandering around the world, the gray life track is not my intention. The sky changes, the earth changes, and the mood changes. Why am I immutable … "


  Publish online for profit


  The reading rate of these online erotic novels is amazing, and the click-through rate reaches tens or millions of times. In order to attract readers, some works also specially indicate their "gold content", such as the novel "Xiang Yan Life" in the category of "Martial Arts Xianxia", and the article specifically declares "Absolutely Xiang Yan". Some authors are unscrupulous and even openly "seek cooperation from publishers". The reporter learned that it has become a common phenomenon for pornographic novels to "go online" at present. With the increasingly fierce competition between original literature websites, more and more websites are trying to gain popularity through pornographic novels in order to make quick profits. Online works are easy to publish, spread quickly, and difficult to supervise, which makes the perpetrators have no fear.


  Recently, the General Administration of Press and Publication has published a "blacklist" of 40 pornographic novels on the Internet, which requires all localities to investigate and deal with them, but in fact, there are far more pornographic novels being spread on the Internet. In real life, it is worrying that the number of cases in which teenagers have taken the road of crime due to this bad influence is increasing. For the future of teenagers and the country, in addition to the relevant departments, the whole society should shoulder a long and arduous task of supervision. Our reporter Jing Li.


Editor: Xun Zhiguo

Young people like nightlife, and Chengdu’s night consumption leads the new first-tier cities.

  According to the data of science and technology platform, in March this year, Chengdu led many night indicators such as catering, hotel accommodation, leisure and entertainment, and film performances.

  With the release of "2022 Urban Business Environment Innovation Report", Chengdu was selected as "2022 Urban Business Environment Innovation City" and Pengzhou was selected as "2022 Urban Business Environment Innovation County (City)".

  "Walk with me in the streets of Chengdu …" In Zhao Lei’s songs, Chengdu is not only a capital of fireworks favored by tourists during the day, but also attracts tourists to linger at night.

  Since the beginning of this year, local consumption has recovered, and the night economy has driven the market vitality. According to the data of science and technology platform, in March this year, the overall order volume of night consumption in Chengdu increased by 26.6% year-on-year, and many night indicators such as catering, hotel accommodation, leisure and entertainment, and film performances led the way, becoming the new first-tier city with the largest order volume and transaction volume at night.

  new life

  Go to work during the day and set up a stall at night

  Young people like nightlife.

  As the weather gets warmer and tourists flock to Chengdu, "night economy" has become a business card of Chengdu.

  In the little red book, some netizens summed up that "you must visit the night market when you come to Chengdu", and there is a three-color night market called "Pattaya Chengdu is elegant"; There is Chunxi Road Night Market, which is close to downtown and has a prosperous location. Jianshe Road Night Market, which has been on fire for many years; There is a rising star and a variety of Liulangwan Night Market …

  In Wenjiang Liulangwan Night Market, there are hundreds of kinds of delicacies, and the average price is around 10 yuan money. In Sanse Road Night Market, cars are transformed into "trunk markets", and hand-made lemon tea, coffee and wine are all best sellers. In the Yinjialin Night Market in Wuhou District, in addition to food and drinks, there are new ways to play, such as skateboarding and billiards.

  Since August last year, Mr. Liu and three friends have set up stalls in the night market. The four young people are all "slash youths", who work separately during the day and gather in the night market at night. From the past three-color road night market to the present Beihu night market, there are shops of Mr. Liu’s "century-old stall". The stalls mainly sell drinks and fried skewers, and the business hours are from 19: 00 to the early morning of the next day. "More and more people, especially young people, have entered the field of stalls, and there are more and more points. This kind of consumption mode and atmosphere is easy for most young people, especially those who like nightlife. " Mr. Liu said.

  In April, a friend from Chengdu, Zhang Hua, came to Chengdu to play. Among the tourist routes designed by Zhang Hua for his friends, night trips to Jinli were included. "The difference between day and night in Jinli is not generally large. After nightfall, the lanterns in the street are lit up one after another, walking on Qingshiban Road and strolling around the ancient streets; When you are tired, you can go to a small teahouse to drink tea, and watch Sichuan Opera and change your face. "

  A local "Sichuan Opera Face-changing Performance Theater" in Jinli was well received. In order to cooperate with tourists who spend at night, the theater is open until around 10 pm, and various group purchase packages are also launched to increase exposure and increase store sales.

  Of course, there are not only Jinli Old Street in Chengdu at night, but also Kuanzhai Lane, Ocean Taikooli, Jiuyanqiao, Tianfu Panda Tower and Dongmen Wharf. As summer approaches, it is also the first choice for many tourists to visit Jinjiang by boat at night.

  In the upsurge of night consumption, Chengdu’s economy is accelerating its recovery. According to the data of science and technology platform, in March this year, the overall order volume of night consumption in Chengdu (from 18: 00 to 6: 00 the next day) increased by 26.6% year-on-year. At the same time, Chengdu led many night indicators such as catering, hotel accommodation, leisure and entertainment, and film performances, and became a new first-tier city with the largest order volume and transaction volume at night.

  new business forms

  Coffee shop embeds a 24-hour bookstore.

  New formats are constantly emerging.

  In addition to offline night consumption, with the rapid development of mobile Internet, online night consumption is gradually becoming a new trend.

  According to the survey data, 65.7% of consumers will spend at night through online channels. In Chengdu, chain brands including Rosen, 7-11, Xiaochaigou, Jianfu, etc. provide 24-hour service online and offline. Among them, the monthly sales volume of take-out in several convenience stores has exceeded 9999.

  "There are many hotels around us, and tourists will buy drinks or disposable travel supplies at night." An employee of a 24-hour convenience store in Chengdu said that the store usually welcomes the peak of consumption from 8: 00 to 10: 00 at night, especially the surge in take-away orders.

  According to the "2022 China City Convenience Store Index" issued by China Chain Store & Franchise Association, Chengdu has the largest proportion of 24-hour convenience stores, and 80% of convenience stores have realized 24-hour business. Especially in Chengdu, "everything can be taken out" has become a part of young people’s nightlife.

  These are just the epitome of Chengdu’s new night economy model. 24-hour hot pot restaurants, light shows, 24-hour bookstores, 24-hour gyms, and night study rooms … In recent years, more and more forms of night consumption have emerged in Chengdu, catering to people’s new demands for healthy living, immersive experience, and trendy culture.

  In Kuanzhai Lane, Chengdu, a coffee shop that has been operating for more than 10 years is trying to diversify: at night, folk singers are invited to sing, and the menu is set with products other than coffee, such as fruit tea, cakes and black tea. There is also a bookstore, which is open 24 hours a day.

  "The location of this store is a quiet place. There is a terrace on the second floor. It is really good to order a cup of Pu ‘er tea to enjoy the moon color on the terrace and look at the tourists below. There is a bookstore next to it, and a row of bookcases is full against the wall, which is open 24 hours a day. " A consumer said that for this small shop, colleagues are also praised.

  In the 24-hour gym of R29 living space in Sansheng Township, there are many kinds of fitness equipment such as elliptical machine, rowing machine and treadmill. Resident Miss Lu is a frequent visitor here. "Generally, around 8 pm every day, many young people will come to exercise." This is a shared gym, which can be selected according to different pricing categories, such as hours, times and monthly subscription, in which the price of 2-hour fitness is 10 yuan money.

  Good policies

  Chengdu will increase

  Support for night economy

  Among the new first-tier cities, Chengdu is one of the first cities to start to exert its nighttime economy and promote the continuous updating and iteration of consumption scenes. As early as 2019, Chengdu issued the "Implementation Opinions on Developing the City’s Night Economy to Promote Consumption Upgrading" (hereinafter referred to as "Opinions"). The "Opinions" mentioned that it is necessary to build night tourist attractions, night audio-visual theaters, night parent-child parks, and night-style neighborhoods.

  "This kind of night economy is responding to and catering to the dividends of national policies, and it is also matching the core demands of consumers. The night economy is a very important starting point for boosting the economy and stimulating domestic demand. " Zhu Danpeng, food industry analyst in China and vice president of Guangdong Food Safety Promotion Association, analyzed.

  This year, the night economy is also placed in an important position in Chengdu’s economic development. On March 21st, at the press conference of Sichuan Provincial Government Information Office on "Accelerating the Cultivation of Comfortable Consumer Brands in Shuli", Li Yuping, the person in charge of Chengdu Municipal Bureau of Commerce, introduced that Chengdu would increase its support for the first store economy, night economy, headquarters economy, cultural tourism consumption and exhibition events. Next, Chengdu will also cultivate and create a number of demonstration and characteristic consumption scenarios to create an international consumption destination.

  With the continuous development of night consumption pattern, Chengdu’s night economy will give birth to more possibilities.

  Chengdu Business Daily-Red Star Journalist Yan Xue

How to treat the "usefulness" and "uselessness" of culture

Original title: How to treat the "usefulness" and "uselessness" of culture?

Zhongqingbao Zhongqingwang reporter Xia Wei

For drinking tea, it is obvious that ordinary white porcelain bowls can meet the demand, but why do we prefer porcelain tea set with fine workmanship? When writing, the arm rest is used to prevent the arm from being stained with ink. Obviously, as long as it has the function of putting the arm, why do we pay attention to its material and the carving on it? When we are moved by the beautiful artistic conception of an ancient poem, when we are fascinated by the exquisiteness and elegance of a handicraft, what do we get from it? What can those humanistic details and artistic values bring to our lives? Or, is culture "useful" or "useless" to our life?

The "uselessness" of culture is also "great use"

In the dialogue session hosted by Bai Yansong at the 15th Cultural China Forum, Pan Lusheng, chairman of China Folk Writers Association, pointed out that "useful" means "practical" and "useless" means aesthetic "useless". Material and spiritual use and life use are both useful and practical, while useless is also useful and even useful.

Pan Lusheng introduced that in Lin ‘an City in the Southern Song Dynasty, the palace culture, the literati culture and the street culture were integrated, which formed the idea of "craft for practical use", and also created a life style of unity of practicality and aesthetics in the Southern Song Dynasty. During this period, the weaving technology was superb, and the fabrics made were dense and light as cicada’s wings. Not only were there various types of yarn, Luo, Qi and Ling, but the silk reeling and embroidery techniques were also superb. The gardens in the Southern Song Dynasty are like three-dimensional landscape paintings with pavilions and winding paths, which contain the spiritual complex and aesthetic artistic conception of literati. From the clay figurines of children in the Song Dynasty in Zhenjiang Museum, to the Children’s Plays in the City in Taipei Palace Museum, from the white porcelain children’s pillows in Dingyao in the Palace Museum, to Song Jin’s Paintings of the Hundred Immortals in Cleveland Art Museum in the United States, all of them reflect the aesthetics and interest of life in which humanities and art are combined with street life.

In contrast, in today’s fast-paced diet and fragmented culture, modern people no longer seem to have an attitude of attaching importance to life aesthetics, and traditional crafts no longer pursue use value. In this context, should we learn from the ancients and return to the "elegant life" way of the Southern Song Dynasty?

"The handicraft tradition of the Southern Song Dynasty is historical and contemporary, which runs through the traditional Chinese aesthetic spirit, lifestyle and cultural taste." Pan Lusheng said. Therefore, he proposed to develop a new economy of Song rhyme culture, take people’s life needs as the guide, enhance cultural life experience, and study how elegant lifestyle can be integrated into today’s life, so that people can gain a sense of cultural identity.

Pan Lusheng believes that, on the one hand, by reviving traditional crafts, we can explore how to better inherit and utilize traditional craft and cultural resources at present, inject the culture of Xixiang into education and cultural communication, and serve people’s spiritual and cultural life. On the other hand, through the development of cultural industry with cross-industry barriers, traditional craft culture can be transformed into the resources of contemporary Song Yun cultural industry, creating higher economic value, thus better serving people’s material and cultural needs.

"Cultural pension" is worth looking forward to.

On the aesthetic level of life, the "usefulness" and "uselessness" of culture may be a philosophical proposition, but in the medical field, the "usefulness" of culture is indispensable. According to Zheng Xiaoying, academician of the Academy of Sciences of developing countries and director of the Peking University Population Research Institute, culture is even more "useful" than science and technology.

Zheng Xiaoying said, "Everyone’s ultimate wish is to grow old healthily and say goodbye to the world happily. This is by no means a problem that can be solved by relying solely on science and technology or medical means, but a realm that must be achieved through the combination of culture, art and technology. In this sense, the infiltration of culture is more important than the development of science and technology. "Zheng Xiaoying believes that" medical art education should be integrated into medical education so that every doctor can accumulate deeper artistic accomplishment and cultural heritage. "

Zheng Xiaoying pointed out that cultural blessing is also needed to deal with the problem of population aging. She introduced that with the intensification of the aging process, the life expectancy of China’s population is also increasing rapidly. However, most of the increased life expectancy is unhealthy, that is, life expectancy with disabilities. Among the disabled people in China, 53% are elderly people. To solve the problems of these elderly disabled people, we need the support of science and technology, but more importantly, we need the support of culture. "Let them be happy and enjoy the benefits brought about by the reform and opening up to the maximum. This is not a problem that can be solved by a simple assistive device."

At the same time, Zheng Xiaoying emphasized the concept of "cultural support for the aged", which is a way to support the aged on the premise that the material needs of the elderly are basically guaranteed, on the basis of meeting spiritual needs, on the basis of communicating emotions, exchanging ideas and having a healthy body and mind, and on the purpose of publicizing individuality, advocating independence and enjoying the spirit of happiness and pleasure. "Cultural pension meets the spiritual needs of the elderly. For the elderly without children, this pension model is particularly important." Zheng Xiaoying said.

How to realize the mutual integration of science and technology and humanities

Undoubtedly, the integration of culture, art and technology can make people’s lives better. So, as an individual, how should we start from ourselves and realize the integration of technology and humanities? This is also a question that Wang Yuming, an academician of China Academy of Engineering and an expert in fluid sealing engineering technology, is often asked.

Wang Yuming laughed and called himself a "science man". "However, although my main business is mechanical engineering, I am not" mechanical "culturally. He is a student of Mr. Ye Jiaying, a consultant of the Chinese Poetry Society, the director of the Poetry Working Committee of colleges and universities, and the president of the Tsinghua University Lotus Pond Poetry Society. It can be said that he is a person who perfectly balances "poetry and distance".

When answering the question "how to realize the mutual integration of science and technology and humanities", Wang Yuming believes that in terms of values, science and technology and humanities and arts are both pursuing truth, goodness and beauty, and they are essentially interlinked; In the mode of thinking, both of them need logical thinking and inspiration epiphany thinking, which can promote each other. The same is true of many masters of science and technology (such as Einstein, Yang Zhenning, Qiu Chengtong, Gu Yuxiu, Qian Xuesen, etc.). However, the most important thing is to have a "pure heart" in both scientific research and literary creation.

On the "Use" of China Culture from the Outside

The Chinese culture has a long history, and the "useful" culture not only created the fashion life of the ancients, but also injected spiritual strength into solving modern social problems, and also brought about an impact on the civilized development of neighboring countries.

In the dialogue session, Cheng Yonghua, former Japanese ambassador extraordinary and plenipotentiary to People’s Republic of China (PRC) and executive vice president of China-Japan Friendship Association, introduced the "use" of Japanese culture to neighboring countries. He said that China’s culture had a profound influence on the Korean Peninsula, Viet Nam and Japan. Take Japan as an example. The Sui, Tang and Song Dynasties were the historical peaks of Sino-Japanese cultural exchanges. During this period, ancient Japan sent 19 groups of envoys to China to study, with a maximum of 600 people at a time. In addition to sending envoys, a large number of international students also came to China from ancient Japan. Many of them stayed for many years, and some even stayed in China to work as officials in Chang ‘an until they died and were buried in Chang ‘an. In 645 AD, the ancient Japanese carried out the "Dahua Innovation" movement, abolished the monopoly regime system in big noble, and established an ancient centralized state with reference to the rules and regulations of the Tang Dynasty in China. During the Song Dynasty, more and more Japanese people came to China to study. Jian Zhen, a monk in the Tang Dynasty, traveled eastward to preach the precepts to Japan and was honored as the ancestor of Japanese Buddhist legalists. The Tang Zhaoti Temple complex built by him and his disciples in Nara, Japan, embodies the architectural characteristics of the Tang Dynasty and is the largest and most beautiful building in Japan’s existing Tianping era. Japanese characters are also born out of Chinese characters. At first, there were only languages but no characters in Japan. In asuka period, Buddhist classics introduced into Japan along with Buddhism made Chinese characters penetrate into Japanese life. The first Chinese characters were used by ancient Japanese as phonography, but they were troublesome in the process of use, so heian period invented katakana and hiragana with reference to the radicals and cursive scripts of Chinese characters. In addition, the present Japanese court music-gagaku,It is also music from the Tang Dynasty in China.

Cheng Yonghua said that Sino-Japanese exchanges have a history of 2,000 years. Today, Japanese young people are still attracted by China’s rapid economic development and technological innovation, and feel that "they should go to China to see more and communicate more".

Whether it is "practical" or "useless", the China culture of the same strain needs and deserves to be passed down and carried forward by contemporary people. As Pan Lusheng said, culture is a nation’s overall lifestyle and value system. If the ancients’ fashion is integrated into contemporary life, we may be able to create a pioneer culture with temperature, connotation and taste in the new era.

Source: China Youth Daily

Wangli Technology AI large-scale psychological screening helps teenagers’ mental health.

In recent years, the mental health problems of teenagers have become more and more prominent, but there is a serious shortage of full-time manpower engaged in campus mental health. In 2022, several cities across the country issued relevant documents to strengthen the management of mental health of primary and secondary school students, and began to explore the working mechanism of screening, early warning and intervention tracking of students’ psychological problems. However, in the actual work, there are still difficulties and problems such as insufficient coverage of psychological screening and early warning, low accuracy and low closed-loop intervention rate.

In July 2021, in order to further improve the pertinence and effectiveness of students’ mental health work, effectively strengthen professional support and scientific management, and strive to improve students’ mental health literacy, the Ministry of Education issued the Notice on Strengthening the Management of Students’ Mental Health, which clearly requires active.With the help of professional tools and means, students’ mental health evaluation work is carried out regularly.Improve the screening and early warning mechanism and implement accurate intervention as soon as possible. The scientific analysis and rational application of the evaluation results, the classification of mental health education programs, and promoteEstablishing the psychological growth file of "one strategy for life".

In order to fully understand the mental health status of primary and secondary school students in the county, screen and investigate students who may have psychological confusion and problems, and improve the forward-looking, targeted and effective work of school mental health education, a county under Ya’ an City, Sichuan Province, in accordance with the implementation plan of mental health assessment for primary and secondary school students in Ya’ an City and other related work requirements,Relying on Wangli Technology to Develop Artificial Intelligence Psychological Evaluation and Screening SystemConduct psychological evaluation activities for students in grades 4-6, junior high school and senior high school in the county.

According to the plan, the mental health assessment lasted for one week, involving nearly 10,000 students in the county. Wangli Technology has formulated a standardized implementation plan for this large-scale psychological evaluation and strictly controlled all aspects of the whole evaluation work. In order to ensure the smooth progress of the evaluation of school students’ mental health status and the establishment of mental health files, Wangli Technology did a lot of preliminary work before the evaluation began, and made the process of psychological evaluation into courseware. Professional psychological technical service personnel systematically trained mental health teachers and class teachers on the operation process and precautions of this evaluation.

During the evaluation process, after the students log in the corresponding account password, the relevant school leaders and mental health teachers guide the students to fill in the answers online through the computer, and systematically evaluate the mental health status of primary and secondary school students from related psychological problems such as emotion, stress, interpersonal relationship and test anxiety. After the evaluation, Wangli Technology systematically summarized and analyzed the evaluation results and generated a detailed evaluation analysis report.

Different from the past, this mental health assessment has changed the decentralized model of each school’s own assessment. Wangli Technology provides a unified assessment service, which can provide multi-level reports such as county (city), school, grade and class, and comprehensively understand the overall mental health of students. Screening students’ mental health and psychological problems,Improve the coverage rate of students’ psychological screening. Combine data analysis and group report to grasp students’ psychological trends in time and establish a psychological growth file of "one policy for life". Through rigorous data analysis, the list of students who need to pay attention to is provided, which provides scientific basis for the timely development of student crisis intervention in the later period, thus improving the pertinence and effectiveness of mental health education and service, and protecting students’ mental health.

Based on artificial intelligence technology, building a big data management platform for students’ mental health can organically combine regular psychological screening of all employees with daily stress dynamic monitoring, which can make the monitoring and early warning of students’ mental health problems more timely and accurate. In addition, relying on the big data platform to establish a full-process management mechanism from screening and early warning to intervention tracking can promote the digital transformation of adolescent mental health work. At the same time, deepen the use of data,Provide data support for scientific decision-making of leaders at all levelsTo help students build a mental health service system.

Complete the world’s leading CT-FFR clinical research with Keya Medical’s independent artificial intelligence technology products: release of ACC.23 TARGET clinical research results.

In the early morning of March 5, Beijing time, the team of Professor Chen Yundai from the Cardiology Center of the General Hospital of the Chinese People’s Liberation Army published a special report on clinical research at the American Heart Association/World Cardiology (ACC/WCC)2023 Conference. Based on the artificial intelligence CT-FFR technology, the clinical research report on the treatment and follow-up of patients with stable coronary heart disease -TARGET trial, the results will be published simultaneously in the top international journals.CirculationJournal (TOP journal in JCR 1 area, impact factor 39.9).

The research was supported by the National Key R&D Program and the Beijing Science and Technology Rising Star Program, and combined with the research teams of cardiology and radiological imaging departments of several top domestic third-class first-class hospitals such as Beijing anzhen hospital affiliated to Capital Medical University, the Second Affiliated Hospital of Zhejiang University Medical College, Qilu Hospital of Shandong University, the First Affiliated Hospital of Xinjiang Medical University, and tongji hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology. The correspondent of this research paper is Professor Chen Yundai, Associate Professor Yang Junjie, Deputy Chief Physician Shan Dongkai and Dr. Wang Xi from the Department of Cardiovascular Medicine of PLA General Hospital are the co-first authors of this paper.

01

Introduction to research

TARGET study is the first multi-center, randomized and controlled clinical study in the world to evaluate the treatment and management of new stable chest pain patients using the field deployment strategy based on machine learning CT-FFR calculation. The research uses the artificial intelligence CT-FFR computing technology independently developed by China (Keya Medical Technology Co., Ltd.), and a total of 1216 patients from six medical centers in China were selected. The pretest probability of obstructive coronary heart disease in the enrolled patients was medium to high, and coronary CT angiography suggested that there was a critical stenosis of 30%-90%. The researchers randomly divided patients into CT-FFR diagnosis and treatment group (experimental group) or standard diagnosis and treatment group (control group). The main end point of the study was the proportion of patients with non-obstructive coronary artery disease or with obstructive coronary artery disease who did not receive revascularization during the follow-up coronary angiography within 90 days. Secondary end points included major adverse cardiovascular events, quality of life outcomes, improvement of angina symptoms and medical costs.

The results showed that compared with the control group, the proportion of patients with non-obstructive coronary disease or obstructive coronary disease who did not receive revascularization in CT-FFR diagnosis and treatment group decreased significantly (28.3% vs. 46.2%, P<0.001). On the whole, there were more patients receiving revascularization in CT-FFR group than in the control group (49.7% vs. 42.8%, P=0.02), but there was no significant difference in the proportion of MACE during the one-year follow-up (hazard ratio, 0.88; 95%CI, 0.59 to 1.30)。 During the follow-up period, the quality of life and symptoms of the two groups were similar, while the medical cost of CT-FFR treatment group tended to decrease. It is concluded that, compared with the standard diagnosis and treatment strategy represented by cardiac stress examination, the on-site deployment of CT-FFR calculation diagnosis and treatment strategy based on machine learning will significantly reduce the proportion of patients who have found non-obstructive coronary artery disease or do not need intervention within 90 days after coronary angiography. In addition, CT-FFR diagnosis and treatment strategy tends to save medical costs and increase the proportion of revascularization in the selected population. At the same time, CT-FFR strategy is consistent with the traditional path in improving patients’ symptoms or quality of life and the incidence of major clinical adverse vascular events.

02

Research enlightenment

TARGET research results show that "CT-FFR strategy based on machine learning in the field is feasible, safe and effective".

In the past 10 years, the extensive use of coronary CTA has promoted the diagnosis and treatment process of coronary heart disease in China. According to statistics, in 2017, the total number of coronary CTA angiography examinations in China reached 4.6 million. Therefore, the simple diagnostic function of coronary angiography is weakening, but among the patients who have received coronary angiography in China, most cases have not found obstructive coronary stenosis in the catheter room. Part of the reason for this phenomenon is that functional examination is not widely used or advanced cardiac imaging technology is not available enough. TARGET study further emphasizes that coronary angiography should only be applied to those patients who are most likely to have obstructive coronary stenosis or benefit from revascularization, and CT-FFR strategy will significantly optimize the management of stable coronary heart disease population.

This study adopts the CT-FFR simulation calculation technology-deep pulse fraction independently developed by Keya Medical Technology Co., Ltd., uses deep learning technology to evaluate the physiological function of coronary artery, and uses artificial intelligence technology to evaluate the FFR of coronary angiography image, which is a deep learning technology independently developed and optimized based on the latest development in the field of computer vision. It can quickly and accurately analyze the non-invasive blood flow reserve fraction. In January 2020, this technology was approved as the first NMPA artificial intelligence medical device class III certificate in China, and now it has become the only CT-FFR product in the world that has been triple-certified by NMPA in China, CE in the European Union and FDA in the United States.

03

Pamela Douglas, MD (Duke Clinical Research Institute, Durham, North Carolina), former president of ACC, led the experiment funded by HeartFlow (PLATFORM and PRECISE research). She pointed out that the most outstanding thing about the TARGET experiment is the novelty of its on-site CT-FFR analysis.

Douglas said:

It is indeed possible that the field deployment method is cheaper and can return the results faster. In clinical practice, if CCTA is used as a first-line test, Douglas said, then the question becomes: "If you have borderline lesions, what should you do next?" For her, "this is a little obvious, because CT-FFR is only a software analysis. Although the previous products are very complicated, it is not without risk to make an appointment for a load test and ask the patient to come back later."

The researchers pointed out:

It is very important to deploy artificial intelligence computing in the field of TARGET research. "The advantage of using artificial intelligence algorithm is that it provides the possibility of field deployment, avoids the need to transfer sensitive medical data, shortens the calculation time and increases the participation of clinicians." They explained that although FFR can also be calculated by field computational fluid dynamics, this strategy is complex and requires a lot of resources. The convenience of machine learning will contribute to the application of CT-FFR in a wider range of scenarios, adding that "on-site CT-FFR strategy is practical and may be more suitable to meet the clinical practice needs in various clinical environments."