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Original transfer network transformation medical network

[Introduction] Cancer-associated fibroblasts (CAFs) are the key components of tumor microenvironment (TME) and play an important role in regulating cancer progression. However, the underlying mechanism of CAFs activation is still unclear.

On April 8, researchers from the Medical College of Kunming University of Science and Technology published a research paper in the journal Cell Death Discovery, entitled "CXC L12 Alone is enough to reprogram normal fibers into cancer-associated fibers". In this study, the researchers found that cancer-associated fibroblasts (CAFs) significantly induced normal fibroblasts (NFs) to acquire the characteristics of CAFs (called CAFs-like fibroblasts, referred to as CEFs for short), including up-regulating α-SMA and vimentin, enhancing the ability of proliferation and migration, and improving the ability of promoting the migration of lung cancer cells. In vivo, CEFs accelerated the growth of A549 xenograft and induced spontaneous lung metastasis. In particular, inhibition of CXCL12 signaling pathway and STAT3 pathway can reduce the transformation from NFs to CAFs, thus inhibiting the progress of lung cancer in vitro and in vivo. This study revealed that CAFs can promote the transformation of NFs into CAFs-like cells through CXCL12/STAT3 axis, and enhance the growth and metastasis of lung cancer. Therefore, inhibiting CXCL12/STAT3 axis is a promising strategy for the treatment of lung cancer and other CXCL12-dependent malignant tumors.

https://www.nature.com/articles/s41420-025-02420-0#Abs1

Research background

01

Cancer-associated fibroblasts (CAFs) are the main components of tumor microenvironment (TME), which promote tumor proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) and drug resistance by secreting growth factors, cytokines and extracellular vesicles, thus promoting tumor development. CAFs is a large number of fibroblasts with α -smooth muscle actin (α-SMA) positive and activated myofibroblast phenotype. Different from normal fibroblasts (NFs), CAFs has stronger abilities of proliferation, migration and contraction. It is generally believed that CAFs mainly comes from NFs where organizations reside, but the mechanism of transforming NFs into CAFs is still controversial.

More and more evidences show that cancer-associated fibroblasts (CAFs) can be activated by signals from tumor cells and matrix environment, which provides a unique insight into the complex interaction in tumor ecosystem. Researchers found that the hardness of extracellular matrix (ECM) can induce mesenchymal stem cells (MSCs) to differentiate into CAFs, thus promoting the invasion and metastasis of triple negative breast cancer (TNBC). In addition, in gastric cancer, CAFs can also "educate" NFs to promote cancer cell proliferation and T cell inhibition. However, the exact mechanism that drives CAFs activation is still largely unknown. Therefore, detailed research is needed to clarify the molecular mechanism of cancer-related fibroblast activation, so as to open up a new anti-matrix therapy approach.

CAFs promotes the transformation from NFs to CAFs in lung cancer.

02

In order to explore the clinical effect of tumor-associated fibroblasts (CAFs) in the process of transforming normal fibroblasts (NFs) into CAFs in lung cancer, the researchers isolated pairs of CAFs and NFs from tumor tissues or corresponding non-malignant tissues adjacent to tumors of several lung cancer patients. CAFs specifically shows highly expressed vimentin and FAP (known CAFs markers), and its ability to promote the migration of lung cancer cells is stronger than that of NFs from adjacent tissues. Then, NFs was treated with CAFs conditioned medium (CM), and then the characteristics of CAFs were analyzed. The levels of CAF markers α-SMA and vimentin expressed in NFs after CAFs CM education increased significantly. These results indicate that CAFs may be helpful to endow NFs CAFs with specific characteristics.

CAFs induces NFs to acquire CAFs characteristics in lung cancer

conclusion

03

To sum up, this study expounds a new molecular mechanism that the interaction between NFs and CAFs promotes the metastasis of cancer cells. CXCL12/ STAT3 pathway is a key participant in NFs-to-CAFs transition, which provides a key therapeutic target for developing new cancer treatment methods.

References:

https://www.nature.com/articles/s41420-025-02420-0#Abs1

Original title: "New Molecular Mechanism! Kungong medical college: an important therapeutic target of new cancer treatment strategy

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1905 movie network news Affected by Typhoon Du Surui, the Beijing-Tianjin-Hebei region has been experiencing heavy rainfall recently. Due to factors such as extremely heavy rainfall and flood discharge in the upper reaches of the river, the risk of waterlogging in Zhuozhou City, Hebei Province has intensified, and the flood control situation is grim, which affects people’s hearts. Many stars in the entertainment industry have joined hands to help Chi.

On August 2nd, according to the official news of China Siyuan Engineering Foundation, "Join Hands with Tomorrow" decided to donate 20 professional rescue boats (including motors) to the disaster area in Zhuozhou, Hebei Province, to assist the rescue team to transfer the trapped people in time, and join hands with China Siyuan Engineering Foundation to set sail for the rescue. At the same time, it will also cooperate with the Sichuan Science and Technology Foundation for Poverty Alleviation and the China Social Assistance Foundation to support 12 professional rescue teams struggling in the front line to meet the just-needed needs of local rescue equipment, emergency materials and logistics support. The list will be announced later, and I would like to thank Huang Xiaoming, Jason Wu, Iola, Lin Chi-ling, Crystal and Zhu Yilong for their timely donations. "

[Autohome Suzhou Discount Promotion Channel] Good news keeps coming! Consumers in Suzhou, if you are interested in this luxury SUV, now is a great opportunity to buy a car not to be missed. It is understood that Lexus RX New Energy is conducting a major promotion in Suzhou, with a maximum discount of up to an astonishing 30,000 yuan. The starting price has been adjusted to 519,000 yuan, which makes the original high-end model more accessible to the people. To take advantage of this price reduction and get the latest and most affordable car purchase price, click the "Check Car Price" button in the quotation form to act now and make the dream car within reach!

With its unique design concept, Lexus RX New Energy shows a very modern appearance charm. The front face design is sharp and delicate, and the large air intake grille adopts the iconic spindle design of the Lexus family, which not only enhances the aerodynamic performance, but also highlights the brand identity. The overall style is elegant and sporty, with smooth lines, and with the low body, it creates a strong sense of movement and power. As a new energy model, the details are integrated with environmentally friendly elements to bring users a more avant-garde visual experience.

The side design is a highlight of the Lexus RX New Energy. Its body size is 4890mm*1920mm*1695mm, and the wheelbase is up to 2850mm, creating a solid and elegant ratio. On the tire specification, the front and rear are sized 235/50 R21, providing good grip and driving stability for the vehicle. The lines are smooth and dynamic, highlighting the unique aesthetic of the RX New Energy as a luxury SUV. Whether it extends from the front to the side of the body or from the rear, it shows a perfect combination of refinement and power.

The interior design of the Lexus RX New Energy is full of luxury and technology. The exquisite leather-wrapped steering wheel not only feels comfortable, but also supports electric up and down + front and rear adjustment to ensure the best control experience for the driver. The 14-inch central control screen stands on the driving platform and is equipped with practical functions such as multimedia system, navigation and telephone, which is convenient for the driver to access information at any time. The interior of the vehicle is made of exquisite leather seats. Whether it is the driver’s seat or the passenger’s seat, it provides multi-directional adjustment functions of front and rear adjustment, backrest adjustment, high and low adjustment and waist support to ensure passenger comfort. The front seats also have heating and ventilation functions, as well as power seat memory, which brings ultimate convenience to passengers. At the same time, the rear seats support backrest adjustment and are equipped with a proportional reclining function to meet the space requirements of different occasions. The overall interior design reflects Lexus’ dedication to detail and quality.

Lexus RX New Energy is equipped with a 2.5L displacement four-cylinder engine with a maximum power of 136 kW and a peak torque of 228 Nm. This engine provides abundant power output for the vehicle, and with the E-CVT continuously variable transmission, it realizes a smooth driving experience and energy-saving and environmentally friendly performance.

Summarizing the owner’s evaluation, he gave high praise to the appearance of the Lexus RX new energy, emphasizing the high-end temperament of its front face design. However, he also mentioned a small regret that the tail design did not fully meet his aesthetic needs. Despite this, the overall performance of this model has won the recognition of the owner, and people look forward to more feedback and experience from the owner.

June 1st is not just a festival for children, but also a carnival for adults who maintain their childlike innocence.

This Children’s Day, Wahaha co-branded the national manga "Under One Person", shouting "Who is still not a baby?", conveying an innocent attitude to life. At the same time, it launched online and offline product promotion activities, gaining praise from consumers and also opening up the June 1 marketing volume.

From this joint move, it can also be seen that Wahaha is not only targeting real children on Children’s Day, but also young people who advocate national culture, and focusing on vertical circles is also one of Wahaha’s strategies to focus more on young people in recent years. How to organically combine the "childlike innocence" represented by AD calcium milk and the IP of Dareguo Manman has become the key to this joint name.

Fans who are familiar with the plot of "Under One Man" may be very easy to get the ingenuity of this Children’s Day joint name. The life of the anime heroine Feng Baobao is a mystery, and she is strong and powerful during the war, but her heart is pure and simple, and she can switch between the two forms of independence and innocence and cuteness at any time, which is very consistent with the idea of AD calcium milk to convey childlike innocence.

In the animation, Feng Baobao, Zhang Chulan, Zhang Lingyu, Wang Ye, Zhuge Qing and other protagonist group members also became smaller under the "magic" of AD calcium milk, and appeared in the classic 220g bottle of AD calcium milk with a cute version image. This is also the first time that 220gAD calcium milk has launched a joint packaging; while the 450mL large bottle packaging is the original character image of the animation, and at the same time customized new flavors of strawberries and peaches. The differentiated joint name makes the meaning of "limited" on Children’s Day stronger, and it can also attract the attention of consumers of different ages.

It’s not a good idea.Online and offline festivals are created at the same time, and "Mengqi" is linked to improve product promotion efficiency

When the protagonist group of "Under One Man" comes to Wahaha Amusement Park to celebrate June 1st, what kind of adventure will happen?

Since May 26, Wahaha’s June 1 marketing "horn" has been sounded in advance. With the release of Wahaha’s official Weibo official promotion of June 1 theme activities and animation TVC, Feng Baobao and other protagonists drank AD calcium milk and became childlike babies in Wahaha amusement park, interspersed with animation eggs to resonate with fans; at the same time, launched a Douyin Talent Challenge, launched interactive sharing gameplay with the theme of "Children’s Day is coming, quickly @the person who called you baby asks you to drink AD calcium milk", and took the lead in establishing the product promotion volume on the eve of June 1.

On June 1st, the joint version of AD Calcium Milk of "Under One Person" took the lead in opening the curtain of Wahaha e e-commerce promotion, and further enhanced the hot-selling topic through limited sales of joint peripherals; offline through the clock in limited-time paradise, Shanghai Lawson, family bag store activities created a comprehensive atmosphere of activities. It is worth mentioning that AD Calcium Milk also released the news of the joint character of Feng Baobao in "Under One Person" on June 1st, which will continue Q Meng’s childlike innocence in July.

Taking advantage of the Children’s Day node, Wahaha launched an online + offline "combination boxing" marketing campaign to further promote AD calcium milk series and new flavor products, continue to enhance brand exposure, consolidate consumers’ minds, and achieve a win-win situation between product volume and sales growth.

Continuous release of IP core, AD calcium milk weaving "childlike universe"

AD calcium milk was born in 1996, and its "debut" has never lost its popularity, and it has always been a strong single product of Wahaha. With its sour, sweet and rich milk aroma, it has been popular for more than 20 years and has become the "favorite" of countless young people. Its "childlike" and "underage" IP attributes have also gained a group of loyal fans who are obsessed with "cute style" and love "two-dimensional".

AD calcium milk obviously also knows its own advantages, and has carried out a systematic "plan layout". Since 2018, it has carried out IP-based integrated marketing, and has successively launched AD calcium milk-flavored moon cakes, zongzi, and ice cream, so that the classic taste of AD calcium milk sour and sweet breaks through the restrictions of the bottle body; subsequently, by cooperating with BilibiliWorld June 1st Manufacturing Festival, customized DIMOO packaging, and Teddy’s collection packaging, it continues to extend vertically to various circles such as trendy play circles and two-dimensional yuan circles, and at the same time strengthens the "Today’s Minor" IP. For a while, "June 1st will drink AD calcium milk" and "drink AD calcium milk in rows" have also become festive atmosphere scenes.

Today, AD calcium milk is still Wahaha’s well-deserved trump card. The best-selling performance for more than 20 consecutive years reflects the strong appeal of a classic beverage product across the time dimension. Wahaha’s official announcement to become the official non-alcoholic beverage sponsor of the Hangzhou Asian Games in 2021 also highlights the hard power and brand influence of established enterprises.

Adults are enthusiastic about June 1, which actually reflects the desire of contemporary young people to temporarily unload the burden of life and retrieve the simplicity and beauty of their childhood. "Who is not a baby yet?", the brand is using its own way to strive to locate the consumer group corresponding to the age group. Wahaha advocates for older children to break the shackles of age and return to their innocence from various angles.

Affected by the price war, the domestic auto market showed strong vitality in March, with retail sales reaching 1.69 million vehicles, up by 6.2% and 53.1% respectively from the same month and the previous month, among which SUV once again took the lead, with sales of 801,070 vehicles, accounting for 47.21% of the market share, up by 10.76% and 47.63% respectively from the same month and the previous month, which shows that the SUV market still maintains a strong growth momentum.

Specifically, the best-selling SUV model in March was 47,917 vehicles, and it was also the only model with a monthly sales of 40,000, leading the second place in Song Pro DM-I (27,446 vehicles). However, although the sales volume of Model Y is good, it is still down by 12.78% compared with the same period of last year, which shows that it is still influenced by its own brands. After all,,, and so on have joined the price war, and the cost performance is very high. However, considering that Model Y has risen against the trend in the price war, it can still have such sales volume, and its competitiveness can be seen.

Undoubtedly, the biggest winner in the SUV market is that three models have entered the top five and four models have entered the top fifteen, and there are both plug-in models such as Song PLUS DM-i, Song Pro DM-i and Tang DM-i, as well as pure electric models. Except Tang DM-i, all four models are frequent visitors on the list, all of which have certain influence. Coupled with the recent launch of the glory version, the price has been lowered and the configuration has increased, and the sales volume is natural.

BYD Song PLUS DM-i is the sales champion of its own brand new energy SUV, and it is also the sales champion of its own brand fuel SUV. The new car was rejuvenated earlier, and the whole system comes standard with 8AT transmission. The level of intelligence is also the best among traditional car companies, and with greater concessions, the sales performance is still strong, but it is not weak next door, and it will be replaced soon, and it will still face greater pressure in the future.

In March, the sales volume declined both in the same period and month-on-month, and it was still the first new force and the first SUV. After all, there have been many heavy new cars recently, such as the new 001, the new model, etc. The old L7 is also clearing its inventory at a reduced price, which has somewhat affected the M7. However, with the help of HarmonyOS car and ADS 2.0, there has been a big discount recently. The price of the rear-drive version has been reduced by 20,000, and the price of the rear-drive intelligent driving version has been reduced by 10,000, which still keeps selling well. It is worth mentioning that the M7 will be redesigned next, the product strength will be improved, and the old models will be reduced in price to clear the inventory. However, they will also be listed. If they are both 250,000-class SUVs, who would you choose?

Surprisingly, the joint venture fuel SUV sold 19,000 vehicles, ranking fifth in the SUV sales list. On the one hand, as a first-line luxury brand, it has a wide popularity and reputation in the market, and naturally has natural advantages in sales. On the other hand, Mercedes-Benz GLC has recently given a big discount, with a price reduction of about 50,000, and more than 370,000 entry models can be bought. Although the price is exchanged for the quantity, the comprehensive strength of GLC is still worthy of recognition. After all, the discount at the same level is about 100,000, which only ranks 15th.

Look at other models on the list, Haval H6, Geely and, all of which are frequent visitors on the list, with more than 10,000 vehicles in March. All four models have good product strength and user base, and they have also received large discounts recently. For example, Feng Landa bought a joint venture compact SUV in the early 110,000 s, which is still very attractive.

Overall, independent brands still occupy an absolute advantage in the SUV market, and the proportion has increased compared with last month. It can be seen that the R&D and production capacity of independent brands in the SUV market has been continuously improved, which can meet the diversified needs of consumers. At the same time, new energy vehicles and fuel vehicles account for half of the list, showing the rapid development of the new energy vehicle market and the increasing acceptance of new energy vehicles by consumers.

In addition, under the price war, the SUV market in March showed the characteristics of diversification and fierce competition. Although consumers pay attention to many factors such as product performance, appearance, configuration and brand reputation, price is still an important influencing factor, and most of the listed models have great discounts recently, but "exchanging price for quantity" is not a long-term solution. The focus should be on brand reputation and product strength to better meet consumers’ demand for car purchase and cope with market changes.

The latest trends of fashion brands

Fashion trends are always changing, and each season has different trends and popular elements.

The latest fashion trends show the innovative ability and forward-looking vision of brands. For example, in autumn and winter this year, many brands have launched turtle neck as their main item, because turtle neck can not only keep warm, but also show fashionable and generous temperament.

The second paragraph: collocation skills of popular elements

When wearing, the correct collocation can make you more fashionable and show your unique style.

When paired with turtle neck, you can choose a pair of slim jeans or a pair of popular wide-leg pants, which is in contrast with turtle neck and shows a fashionable and generous feeling.

In addition, it can be paired with a pair of fashionable boots or wild white shoes to enhance the overall fashion.

The third paragraph: the representative works of the brand

Fashion brands have been trying to launch representative works to bring new fashion experiences to consumers.

For example, brand X recently launched an innovative turtle neck with unique materials and tailoring, which is both warm and fashionable.

This turtle neck is not only suitable for middle-aged women to wear, but also suitable for young people to show their personality.

The fourth paragraph: the influence of brand in fashion.

The influence of a brand in the fashion world is determined by its strength, popularity and influence.

Brand X has won a good reputation in the fashion world with its innovative design and unique style, and attracted a large number of loyal consumers.

Turtle neck with brand X has become a hot item in fashion, and has been loved and sought after by many people.

The fifth paragraph: summary and thinking

Fashion trends change rapidly, and brands need to innovate constantly to meet the needs of consumers.

As a part of fashion trend, turtle neck can not only bring people a sense of fashion, but also keep warm, especially suitable for wearing in cold weather.

It is suggested that consumers choose turtle neck that suits their own style, and reasonably match other clothes to show their unique personality.

Finally, do you prefer fashion or keep your own personal style?

What do you think of the latest trends and popular elements of fashion brands?

Leave a message to share your thoughts!

Words: 385 words

Lei Feng, a good soldier of China People’s Liberation Army, is admired and loved by people all over the country for his selfless dedication and noble character. However, due to technical limitations, Lei Feng’s image data before his death is not complete, which makes many people have doubts and misunderstandings about his characters and deeds.

Now, with the continuous development and application of artificial intelligence technology, we have the possibility to repair the image of Lei Feng before his death, so that we can get to know this great man again.

Through AI technology, the image of Lei Feng before his death can be repaired and reconstructed, making his image more real and clear. This will not only help us better understand Lei Feng’s life and deeds, but also inspire more people to learn Lei Feng’s spirit and inherit Lei Feng’s patriotism and humanitarianism.

The process of restoring Lei Feng’s image before his death is not simple, and it needs a lot of data and algorithm support.

First of all, it is necessary to collect photos and video materials of Lei Feng before his death, and then analyze and reconstruct these materials through image processing and deep learning algorithms. Finally, a group of high-definition and authentic images of Lei Feng were obtained, which made people feel his image and deeds more truly.

Restoring the image of Lei Feng before his death is not only a technological innovation, but also a cultural inheritance and value transmission.

Through this AI technology, the history and culture of China can be better spread, and at the same time, more people can be encouraged to learn from Lei Feng’s spirit and inherit his patriotism and humanitarianism.

Marco Conidi, an Italian singer who wrote the famous song "Mai sola mai" for Rome in 2006, also participated in the protest. He wrote on Instagram: "The most important thing tomorrow is that everyone brings a white handkerchief. Let’s wave it before the game to protest that our respected coach has been absurdly disqualified from conducting. Everyone supports Mourinho!"

In recent years, with the rapid development of Internet of Things technology, IOT card has become a topic of great concern. As a special SIM card, IOT card can transform various items into IOT devices that can be connected to the Internet, giving them the ability of wireless communication. In this paper, we will discuss the reasons why IOT card is a hot topic, as well as its application and development trend.

First, why has the IOT card become a hot topic?

IOT card has become a hot topic for the following reasons:

The rise of smart home: With the gradual popularization of the concept of smart home, people’s demand for smart home equipment is also growing. IOT card can connect smart home devices with the Internet, thus realizing remote control and data sharing, which greatly facilitates people’s lives.

Application expansion of Internet of Things: Internet of Things technology has been more and more widely used in smart cities, intelligent manufacturing, intelligent transportation and other fields, and the IOT card, as an important part of Internet of Things equipment, has attracted more attention.

Advantages of low cost and power consumption: IOT card adopts low-power wide area network technology (LPWAN), which has the advantages of low cost, low power consumption, low bandwidth and long-distance transmission. This means that IOT cards can be applied to a wider range of fields and further promote the development of the Internet of Things.

Second, the application of IOT card

The application scope of IOT card is very wide, mainly reflected in the following aspects:

Smart home: IOT card can connect all kinds of smart home devices to the Internet, such as smart door locks, smart lighting, smart home appliances and so on. These devices can realize remote control and data sharing through the Internet, which is convenient for people’s lives.

Smart city: IOT card can connect all kinds of devices in the city to the Internet, such as smart bus, smart parking, smart street lamps and so on. These devices can realize intelligent management through the Internet, and improve the service level of the city and the quality of life of residents.

Intelligent medical care: IOT card can connect all kinds of medical equipment to the Internet, such as telemedicine and health monitoring. These devices can be implemented through the Internet.

Realistic on-site monitoring, telemedicine, etc., to improve the efficiency and quality of medical services.

Intelligent transportation: IOT cards can connect transportation equipment to the Internet, such as intelligent vehicles and intelligent traffic lights. These devices can realize intelligent management through the Internet and improve traffic efficiency and safety.

Intelligent manufacturing: IOT card can connect industrial equipment to the Internet, realize intelligent management of industrial equipment, and improve production efficiency and quality.

Third, the development trend of IOT card

The future development trends of IOT cards mainly include the following points:

Large-scale application: With the gradual popularization of Internet of Things technology, IOT cards will be more widely used, which will further promote the development of Internet of Things.

Industry consolidation: The industrial chain of IOT cards will be gradually integrated, and enterprises in different links will cooperate more closely, thus realizing the standardization and scale of IOT card production.

Improvement of low-power technology: the core technology of IOT card is low-power technology, and the future IOT card will pay more attention to the improvement and application of low-power technology.

Improvement of security: With the increasing application of IOT cards, the security of IOT cards will become an important issue. In the future, the IOT card will strengthen the security guarantee and improve the trust and satisfaction of users.

The combination of AI and IOT card: The combination of artificial intelligence and IOT card will bring more innovative applications, thus further promoting the development of IOT technology.

IV. Conclusion

In a word, as a key component of the Internet of Things, IOT card has a wide range of application scenarios and broad development prospects. With the continuous development of technology and the continuous expansion of application scenarios, I believe that IOT cards will be more widely used in smart homes, smart cities, smart medical care, intelligent transportation, intelligent manufacturing and other fields in the future. At the same time, the industry consolidation of IOT card, the improvement of low-power technology, the improvement of security and the combination with artificial intelligence will also become important trends in the future development of IOT card.

[This article was originally issued by the official Qingyi IOT Card, and the source of reprinting needs to be noted]