松江大学城快餐服务

　　On September 6th, according to the website of Shandong Provincial Government, the People’s Government of Shandong Province issued the Reply on the Investigation Report of "4.15" Major Fire Poisoning Accident of Jinan Qilu Tianhe Huishi Pharmaceutical Co., Ltd., and determined that "4.15" Major Fire Poisoning Accident of Jinan Qilu Tianhe Huishi Pharmaceutical Co., Ltd. was a production safety responsibility accident, and the responsible person was investigated according to the law and discipline.

　　The reply shows that the following 11 people were arrested by the procuratorate and the public security organs took measures:

　　1. Xu Shukun, a safety officer in the fourth workshop of Jinan Qilu Tianhe Huishi Pharmaceutical Co., Ltd., has been arrested by the procuratorial organ on suspicion of constituting a major liability accident, and it is suggested that the judicial organ should investigate his criminal responsibility according to law.

　　2. Wang Yunzhong, the deputy director of Workshop 4 of Jinan Qilu Tianhe Huishi Pharmaceutical Co., Ltd., has been arrested by the procuratorate for allegedly constituting a major liability accident. It is suggested that the judicial organs should investigate his criminal responsibility according to law.

　　3. Gao Xin, the director of the fourth workshop of Jinan Qilu Tianhe Huishi Pharmaceutical Co., Ltd., has been arrested by the procuratorate on suspicion of constituting a major liability accident, and it is suggested that the judicial organs should investigate his criminal responsibility according to law.

　　4. Zhao Zhiming, the security officer of EHS office of Jinan Qilu Tianhe Huishi Pharmaceutical Co., Ltd., has been arrested by the procuratorial organ on suspicion of constituting a major liability accident, and it is suggested that the judicial organ should investigate his criminal responsibility according to law.

　　5. Chen Ming, director of EHS and assistant to the general manager of Jinan Qilu Tianhe Huishi Pharmaceutical Co., Ltd., has been taken measures by the public security organs for allegedly constituting the crime of major liability accident, and suggested that the judicial organs should investigate his criminal responsibility according to law.

　　6. Li Baoyong, the legal representative, chairman and general manager of Jinan Qilu Tianhe Huishi Pharmaceutical Co., Ltd., has been taken measures by the public security organs for being suspected of constituting a major liability accident, and suggested that the judicial organs should investigate his criminal responsibility according to law.

　　7. Ji Guozhong, the on-site person in charge of the pipeline reconstruction project of Xinbang Construction Group Co., Ltd., has been arrested by the procuratorial organ on suspicion of constituting a major liability accident, and it is suggested that the judicial organ should investigate his criminal responsibility according to law.

　　8. Kong Fanqiang, the project leader of Xinbang Construction Group Co., Ltd., has been arrested by the procuratorate on suspicion of constituting a major accident, and it is suggested that the judicial organs should investigate his criminal responsibility according to law.

　　9. Xiao Sichao, deputy general manager of Xinbang Construction Group Co., Ltd., has been arrested by the procuratorate on suspicion of constituting a major liability accident, and suggested that the judicial organs should investigate his criminal responsibility according to law.

　　10. Miao Qingming, the general manager of Xinbang Construction Group Co., Ltd., has been arrested by the procuratorial organ on suspicion of constituting a major accident, and suggested that the judicial organ should investigate his criminal responsibility according to law.

　　11. Song Zhe, the head of the Refrigerant Group of the R&D Center of Chaoyang Guangda Chemical Co., Ltd., has been taken measures by the public security organs because he is suspected of constituting a major liability accident, and suggested that the judicial organs should investigate his criminal responsibility according to law.

　　The following three people suggest that they be transferred to judicial organs for criminal responsibility:

　　1. Bai Songquan, the legal representative and general manager of Chaoyang Guangda Chemical Co., Ltd., is suspected of constituting the crime of major liability accident, and suggested that the judicial organs should investigate his criminal responsibility according to law.

　　2. Zhao Chunge, deputy general manager of Chaoyang Guangda Chemical Co., Ltd., is suspected of constituting the crime of major liability accident, and suggested that the judicial organs should investigate his criminal responsibility according to law.

　　3. Qi Xiaoguang, the security minister of Chaoyang Guangda Chemical Co., Ltd., is suspected of constituting the crime of major liability accident, and suggested that the judicial organs should investigate his criminal responsibility according to law.

　　The following 16 people suggested giving disciplinary and administrative sanctions and organizing treatment:

　　1. Liu Xuan, party member of the Communist Party of China, is the deputy director of the Second Division of Supervision of Licheng District Emergency Management Bureau in Jinan, responsible for the comprehensive work of safety supervision and management of hazardous chemicals. It is recommended to give him a serious warning within the party and dismissal from government affairs.

　　2. Guo Xinjiang, party member of the Communist Party of China, is the chief clerk of the Supervision Brigade of Licheng District Emergency Management Bureau of Jinan City, and the head of the law enforcement group of the Supervision Brigade. It is recommended to give him a serious warning within the party and dismissal from government affairs.

　　3. Zhang Yong, party member, Deputy Investigator of Licheng District Emergency Management Bureau, Ji ‘nan. It is suggested that the government record be given a greater punishment.

　　4. Sun Jingping, party member, Party Secretary and Director of Licheng District Emergency Management Bureau, Jinan City. It is recommended to give him a demerit in government affairs.

　　5. Li Renfeng, party member, Deputy Secretary of the Party Working Committee and Director of the Office of Dongjia Street, Licheng District, Jinan City. It is recommended to admonish him.

　　6. Ma Xiaobao, party member, secretary of the Party Working Committee of Dongjia Street, Licheng District, Jinan City. It is recommended to admonish him.

　　7. Yin Jiming, party member, Party Secretary and Director of Licheng District Bureau of Industry and Information Technology, Jinan City. It is suggested to criticize and educate them.

　　8. Zhang Qingguo, party member of the Communist Party of China, member of the Standing Committee and deputy head of Licheng District Committee of Jinan City. It is recommended to give him a government warning.

　　9. Choco, party member, Party Secretary and Director of Jinan SASAC (former Deputy Secretary and District Head of Licheng District Committee). It is suggested that it be ordered to make an in-depth inspection.

　　10. Wu Chengbing, CPC party member, Secretary of Licheng District Committee of Jinan City. It is suggested that it be ordered to make an in-depth inspection.

　　11. Zhang Lei, party member of the Communist Party of China, is a member of the Party Group and Deputy Director of Jinan Emergency Management Bureau. It is recommended to admonish him.

　　12. Shi Ting, party member, a staff member of Feicheng Construction Engineering Quality and Construction Safety Service Station. It is recommended to give him a warning within the party and a record of government affairs.

　　13. Song Guangjin, party member, director of Feicheng Urban Housing Expropriation Center (formerly the stationmaster of Feicheng Construction Safety Supervision Station). It is recommended to give him a warning within the party and a record of government affairs.

　　14. Wei Guangjun, party member, director of Feicheng Housing and Urban-Rural Development Bureau (former deputy secretary of the Party Group of Feicheng Housing and Urban-Rural Development Bureau). It is recommended to give him a demerit in government affairs.

　　15. Dong Qinghuan, party member, Party Secretary and Director of Feicheng Housing and Urban-Rural Development Bureau. It is recommended to give him a government warning.

　　16. Li Songlin, party member of the Communist Party of China, is a member of the party group and deputy director of Tai ‘an Housing and Urban-Rural Development Bureau. It is suggested to criticize and educate them.

　　The Jinan Municipal Government instructed the Jinan Emergency Management Bureau and other relevant departments to impose administrative penalties on Qilu Tianhe Huishi Pharmaceutical Co., Ltd. and its related personnel in accordance with relevant laws and regulations. The Tai ‘an Municipal Government instructed the Tai ‘an Housing and Urban-Rural Development Bureau and other relevant departments to impose administrative penalties on Xinbang Construction Group Co., Ltd. and its related personnel for illegal acts in accordance with relevant laws and regulations. In accordance with the relevant laws and regulations, Shandong Provincial Emergency Management Department imposed administrative penalties on Qilu Tianhe Huishi Pharmaceutical Co., Ltd., Xinbang Construction Group Co., Ltd. and Chaoyang Guangda Chemical Co., Ltd., and revoked the safety production license of dangerous chemicals of Qilu Tianhe Huishi Pharmaceutical Co., Ltd. It is suggested that the Liaoning provincial government instruct the relevant departments to impose administrative penalties on Chaoyang Guangda Chemical Co., Ltd. and its related personnel in accordance with relevant laws and regulations, and confiscate the illegal income of Chaoyang Guangda Chemical Co., Ltd. In view of the fact that Chaoyang Guangda Chemical Co., Ltd. failed to implement the relevant laws and regulations and was responsible for the accident, it is suggested that the Liaoning provincial government and its relevant departments should investigate the illegal and illegal production and operation of Chaoyang Guangda Chemical Co., Ltd. according to law, and the relevant governments, departments and their personnel who failed to seriously implement their supervisory duties should be handed over to the relevant departments for party discipline and government affairs investigation and punishment according to the cadre management authority. (CCTV reporter Zhang Ming)

　　Seven suspects in Qilu Tianhe Huishi Pharmaceutical’s "4 15" major fire poisoning accident were arrested.

　　At about 15: 37 on April 15, 2019, Qilu Tianhe Huishi Pharmaceutical Co., Ltd., located in Licheng District, Jinan City, Shandong Province, had a major accident during the renovation of the refrigerant water (ethylene glycol solution) system pipeline in the basement of the freeze-dried powder injection production workshop, resulting in 10 deaths and 12 minor injuries.

Special feature of 1905 film network Eight months after its release in North America, it finally landed in China last week.

Although it is a harmonious and joyful version of "I Love My Family", Xiaobajie still has charm, winning more than 60 million box office on the first day, which proves that he is still the most "coquettish" boy in Marvel Comics.

At present, two books in this series have been accumulated.10.3 billion RMBAt the global box office, the freshness of rotten tomatoes is over 80%.

Created the miracle of R-rated superhero movies, and let more people know the man behind "Deadpool" — —Ryan Reynolds.

From then on, when he was mentioned, the first person who appeared was no longer the husband of Scarlett Johansson or Blake Lively, but the walking "Deadpool Ben Shi".

Last weekend, ryan reynolds parachuted into China, first provoking "Wolverine and wonder woman’s trip to China was too boring".

Then he exposed and sharply evaluated China’s "superheroes" in interviews.In the end, the cucurbit dolls of pick formed the China X special attack team..

The deity’s endless personality of "mouth gun" makes people confused between the inside and outside of the play.

Perhaps the actor’s "highest" realm is to live himself into a role.

Ryan reynolds is just like this, and it is also due to this subtle connection that his interpretation of the lowly has a mudslide-like charm and persuasiveness.

Pre-Deadpool era

Green box office poison

Ryan reynolds, born in 1976, is 43 years old. There are many film and television works, but only a handful of masterpieces are well known to the public.

When interviewing him, a reporter from The New York Times had deliberately printed out the scores of all his works on "rotten tomatoes". Ryan didn’t want to see them at all, but cast a caring look at the reporter. "Are you okay? You must be very painful in the process of statistics. "

He doesn’t deny that he has acted in bad movies. Among them, the most "destructive" one is in 2011.Green lantern.

At that time, Ryan was in the rising period of his career, and a series of word-of-mouth love comedies such as "Love Choose One" made him a popular male god in Hollywood.

Small-budget independent films also fully demonstrated his extraordinary acting skills, and in 2010, he was awarded the first place in the world as the sexiest man.

At this time, Ryan urgently needs a blockbuster to consolidate his first-line position. On the other hand, it is undoubtedly of great significance to DC.Warner Bros. invested 250 million yuan only to create a superhero blockbuster that can compete with Marvel Comics.

No one expected that a win-win film would eventually become a complete "loss-making".The investment of $250 million only gained 220 million global box office, which not only delayed the sequel indefinitely, but also cast a heavy shadow on the prospect of the whole DC universe.

After all, word of mouth at the box office is not Ryan’s pot.

Warner and the director want to imitate the "dark knight", paying too much attention to special effects and sacrificing the character is the fundamental reason. But as the leading actor, Ryan is naturally to blame.

Since then, ryan reynolds’s career has embarked on a period of water reversal.

In 2011, "Two Men Became Wrong" cost $52 million, and the box office cost $37 million. In 2013, the cost was $130 million, and the box office was only 34 million; Even the cartoons dubbed by him have hit the box office.

It’ s simply a performance, and drinking cold water has become a "box office poison" in the eyes of the media.

RR has always been "bitter" about this failed attempt to surpass Britain, and was repeatedly pulled out to whip the corpse and spit in the "Deadpool" series.

For example, before becoming a superhero, I have a strong inner OS: "Don’t make the uniform green.”。

For another example, when you encounter a "dark inner" cable, you directly spit it out: "So dark, you must be sent by DC universe!"

There’s a scene in Death Attendant 2 in which a lowly boy crosses back and shoots ryan reynolds in the head, which is about to open the script of Green Lantern, enough to see how deep the resentment is.

However, The Green Lantern is not without its merits. You know, it is through this play that ryan reynolds became attached to the heroine Blake Lively. As the saying goes: a thousand dollars can’t buy her, so RR doesn’t lose money.

Grinding a sword in 11 years

Without him, there would be no Deadpool.

The fate between ryan reynolds and Deadpool was predestined.

The screenwriter Rhett Reese once commented on him: "If you stay in the same room with Ryan, you will soon find that he is the most interesting person in that room."

Before meeting Deadpool, RR played the role of Hannibal the Vampire Hunter in another super-English movie, which was also a witty joke.

It is said that it was during the filming of Blade 3 that he learned about the role of "Deadpool", which is infinitely suitable for his inner world, through a producer.

But in the circumstances at that time, "Deadpool" was obviously not the ideal candidate for the production company, and Ryan’s lobbying failed.

In 2009, Deadpool finally got a chance to play in a supporting role, butRyan and Deadpool fans were not satisfied with the strange setting of long knives in their hands and the sad ending of being sewed on their mouths.

Ryan also revealed in a later interview that most of the scenes were not even performed by himself, but were completed by Fowles looking for a stuntman.

Before deciding to star in The Green Lantern, he telephoned FOSS executives with a glimmer of hope and said, "If you don’t film Deadpool, I will" defect "to play the Green Lantern". Unexpectedly, the answer is still a firm "No".

In Ryan’s view, The Green Lantern is only a last resort substitute, and Deadpool is his life’s core monuments and true love. Even in the publicity of The Green Lantern, there are three sentences that don’t leave Deadpool.

"The Green Lantern" saved the street and almost sentenced Deadpool to death. At that time, Hollywood didn’t have enough foresight and courage to believe that an R-rated anti-hero film could make money.

The story after that is familiar to everyone. When the negotiations were deadlocked for many times, the "Deadpool" team quietly posted the internal test fragments on the Internet, which received great response.It is hard to use the "American tap water" to force Gongfu to give the green light.

Although it is the least investment in superhero movies, it just allows the team to concentrate on polishing the characters, writing "jokes", and exerting their imagination when the special effects money is not enough, which makes the action drama of Deadpool unique.

Some people say that Ryan is the soul of Deadpool. He is an actor, producer and invisible screenwriter. No wonder Wernicke, one of the screenwriters, once said: "Our original script was only one page, which said’ Let Ryan improvise’."

Ryan once proudly said, "Apart from the cartoonist, I can say that I spend the most time on Deadpool. I may not understand the special effects, but I am very clear about the characters and the tone of the film. "

After the success of the first film, FOSS increased the investment in the sequel to 150 million. Director tim miller further hopes to make the sequel into a grand super blockbuster, butRyan insisted on continuing the last "small but refined" mode, with mouth guns as the main part and special effects as the supplement.

In the end, producer Ryan’s persistence prevailed, and Miller announced his withdrawal, and david leitch took over.Ryan described himself and Deadpool as destined for each other. Maybe he can compromise in other movies, but in Deadpool, there is only one way to go black.

It is Ryan’s persistence that allows us to see the little bitch who is still talkative, funny and good at cooking poisoned chicken soup in Dead Waiter 2. The film’s global box office of 740 million and the freshness of 83% rotten tomatoes are enough to prove the correctness of this insistence.

After 11 years of brewing and two phenomenal films, ryan reynolds has firmly bound himself to "Deadpool".

Even he himself said: "Deadpool is like my second personality."Sometimes, in the play already can’t distinguish.

On second thought, what’s wrong with living as Deadpool? Life is too sad to match the poisoned chicken soup. "The greater your ability, the less responsible you are. You may be super, but you don’t have to be a hero!"

Coping well with insomnia at high altitude

■ Liberation Army Daily reporter Sun Xingwei

　 Jiang chenhui

A soldier Xiao Zhang: I have been stationed in the plateau for some time. After coming to the plateau, I often have insomnia at night, and I can’t sleep over and over again. Even if you fall asleep, you will wake up early. Due to the poor quality of sleep at night, I always feel depressed during daytime training, and my training results are stagnant. With these pressures, it is more difficult for me to sleep at night. This vicious circle makes me very anxious. How to keep a good sleep?

Zhu Zhiru, Military Plateau Medical Research Center: Xiao Zhang’s condition is high altitude insomnia. The hypoxia environment at high altitude can easily lead to the decline of sleep quality. A series of altitude sickness caused by hypoxia, such as headache and dizziness, will also indirectly affect the quality of sleep. In addition, officers and men may suffer from insomnia due to psychological stress, heavy training tasks and irregular life during their training at high altitude.

If the officers and men suffer from insomnia after entering the plateau, they can apply sleep cognitive behavioral therapy to help them improve their sleep. Sleep cognitive behavioral therapy includes five aspects: sleep hygiene education, sleep stimulation control, sleep restriction, cognitive therapy and relaxation training.

Sleep hygiene education. Developing good sleep hygiene habits is conducive to improving sleep quality. I suggest you pay attention to the following points: avoid drinking coffee, strong tea and smoking a lot after dinner; Adhere to regular sports, and exercise for not less than 30 minutes every day; Do not exercise vigorously within 3 hours before going to bed; Don’t eat too much at dinner or fall asleep on an empty stomach; Keep the sleeping environment quiet and comfortable.

Sleep stimulation control. Sleep stimulus control is mainly to establish a positive relationship between bed and sleepiness. Insomnia people can do the following to establish good sleep stimulation control, and then achieve the purpose of improving sleep: do not do things unrelated to sleep in bed; Determine the appropriate time to go to bed and get up according to the actual situation; If you can’t fall asleep after lying in bed for more than 20 minutes, you can get up and do some relaxation activities, and then go to bed when you are sleepy; No matter how late you went to bed the day before, you should get up on time the next morning.

Sleep restriction. The time spent lying in bed is called bed time, and the time to really fall asleep is called sleep time. Sleep restriction is to increase sleep motivation by shortening the waking time in bed. Insomnia people can pay attention to their sleep situation and consciously record the bed rest time and sleep time every night. At the same time, learn to calculate sleep efficiency. Sleep efficiency = sleep time/bed time ×100%. For example, go to bed at 10: 00 at night, get up at 6: 00 in the morning, and stay in bed for 8 hours. If the sleep time is 6 hours, the sleep efficiency is 75%. If the sleep efficiency exceeds 85%, you can increase the bed rest time by 20 minutes; If the sleep efficiency is lower than 80%, reduce the bed rest time by 20 minutes; If the sleep efficiency is between 80% and 85%, the bed rest time will not change. It is recommended to stay in bed for at least 5 hours every day.

Change the unreasonable cognition of sleep. Many insomniacs have unreasonable cognition of sleep, such as thinking that they don’t sleep well if they sleep less than 8 hours a day. Sleep needs vary from person to person, so it is suggested that you try to change the following unreasonable sleep cognition: ① Correct unrealistic sleep expectations, such as expecting to fall asleep immediately after lying down, expecting to get more than 8 hours of high-quality sleep every day, and expecting to sleep until dawn every day. 2 fall asleep naturally, don’t pay too much attention to how long you have slept; Avoid breaking sleep patterns and trying to fall asleep while awake. 3 If there is insomnia, don’t worry too much. Transient insomnia will not cause irreversible damage to the body, and insomnia can be alleviated by scientific methods. ④ Don’t associate work mistakes with poor sleep at night.

Relax training. If you are in a state of mental and physical tension before going to bed, it will lead to insomnia. Comrades can relieve anxiety and tension through relaxation training, thus helping them to fall asleep quickly. Abdominal breathing is a commonly used relaxation training method, which has a certain effect on relieving tension. Consciously carrying out abdominal breathing before going to bed can make people in a calm and relaxed state, thus reducing stress and improving sleep. The operation method of abdominal breathing is as follows: lie on the bed, keep your body relaxed, and then inhale through your nose. When inhaling, feel the breath pass through the nasal cavity, throat, lungs, and reach the abdomen, and let the abdomen expand outward to the maximum extent. After holding your breath for 5 seconds, exhale slowly through your mouth to make your abdomen slowly fall back. Repeat abdominal breathing until you feel safe, calm and relaxed. When doing abdominal breathing, you can also give yourself positive psychological hints, such as "I am calm and I am relaxed".

Under normal circumstances, the quality of sleep will be improved obviously if you insist on cognitive behavioral therapy for 4 ~ 8 weeks. People with long-term insomnia can appropriately extend the time of sleep cognitive behavioral therapy. If you still can’t relieve insomnia after trying sleep cognitive behavioral therapy, it is recommended to consult a professional doctor.

Health link

Small coup of self-help sleep

■ Zhang Xi

Sleep is an indispensable physiological demand of the body and an important part of health. Good sleep helps to restore energy, eliminate fatigue and enhance the body’s immunity. In daily life, people may suffer from insomnia, mainly manifested as being unable to sleep, unable to wake up and unable to sleep well. Here, I would like to share some practical methods to relieve insomnia.

Keep a sleep diary. Keeping a sleep diary can help us understand our sleep patterns. Insomnia people can keep a sleep diary for a week or several weeks, including the time of going to bed, the time of falling asleep, the feeling after getting up in the morning, the total sleep time last night, the environmental factors, psychological factors and physiological factors that affect sleep, etc., in order to understand the dynamic changes of sleep state in the near future. By keeping a sleep diary, some people can find out their sleep problems, find out the factors that may affect sleep, and take corresponding improvement measures. Keeping a sleep diary for people with severe insomnia can help doctors understand their sleep more quickly and accurately.

Music therapy. Listening to music helps to relieve tension, thus promoting sleep. Studies have shown that listening to calming music for 45 minutes before going to bed every day for 3 weeks can obviously shorten the sleep time and prolong the sleep time. If you have mild insomnia symptoms, you can listen to some music with slow and steady rhythm before going to bed, such as Qin Qu "Running Water" and "Moonlit Night on a Spring River".

Hot foot bath or hot bath. Soaking feet with hot water before going to bed can dilate the capillaries of feet and increase the blood flow of limbs, thus playing the role of calming the nerves and helping sleep. When soaking feet with hot water, it is best to choose a deeper bucket, and the amount of water should be soaked to more than half of the calf. The water temperature should not be overheated, and it is recommended to be around 40 degrees Celsius. Don’t soak your feet for too long. Generally, it is recommended to soak your feet for 15 ~ 30 minutes. Hot water bath can dilate the blood vessels in the whole body and reduce the blood flow of internal organs. As the blood flow to the brain decreases, the brain will feel tired, thus promoting sleep.

Auricular point pressing. Modern medicine believes that insomnia is caused by the imbalance between excitement and inhibition in the cerebral cortex. There are abundant nerves around the ear. Pressing and stimulating the points in the ear can adjust the excitement and inhibition of the central nervous system and help improve the quality of sleep. The main operation steps of auricular point pressing are as follows: Select the pillow point and the point before hanging, take a disposable auricular point paste, and apply some pressure to it, which is suitable for local fever and swelling. It is generally recommended to press auricular points before going to bed. Pay attention to the following items when pressing: avoid sticking ear points to be wet to prevent skin infection; The sticking time in summer should not be too long, and it is recommended not to exceed 3 days; It is not suitable to apply when there is chilblain and inflammation in the ear; If you feel pain at the sticking point when lying on your side, you can take off the ear acupoint sticking; Don’t rub your ears when pressing, so as not to rub your skin and cause ear point infection.

　　CCTV News:At 8 o’clock every day, CCTV will sort out the big and small things that happened around us within 24 hours.

　　[Focus]

　　According to Xinhua News Agency, on June 17th, Tu Youyou’s team plans to release a major breakthrough in scientific research! Stay tuned! ! !

　　● As of 10: 00 on June 16th, 6.14 million people in Zhejiang, Fujian, Jiangxi, Hunan, Guangdong, Guangxi, Chongqing and Guizhou provinces have been affected by this storm and flood disaster, of which 88 people were killed and 17 people were missing, resulting in a direct economic loss of 20.13 billion yuan.

　　● As of June 15, 2019, 31 provinces across the country have published statistical bulletins on national economic and social development, and the data of permanent residents have been released immediately. Guangdong Province has ranked first for 13 consecutive years.

　　● The reporter learned from the Ministry of Culture and Tourism on June 16th that 30,000 tourist toilets have been built, renovated and expanded nationwide since the implementation of the New Three-year Action Plan for the Construction and Management of National Tourist Toilets (2018-2020) for one and a half years, and 47% of the targets and tasks of the new three-year plan have been completed. It is reported that from 2018 to 2020, a total of 64,000 tourist toilets need to be built, renovated and expanded nationwide.

　　● The first giant panda pavilion on the Qinghai-Tibet Plateau opened in Xining, Qinghai on the 16th, and four giant pandas from chengdu research base of giant panda started a three-year journey of popular science education.

　　[Expo]

　　● According to Agence France-Presse, an Aeroflot passenger plane made an emergency landing and caught fire at Moscow Sheremityev airport last month, killing 41 people. Russian investigators recently said that the autopilot system of this passenger plane was hit by lightning.

　　● The Indian Ministry of Finance issued an announcement to impose tariffs on 28 American products, including almonds, beans and walnuts.

　　● According to the US "World Journal" report, recently, Boeing Company of the United States issued a warning statement, saying that the switch of the engine fire extinguishing system of Boeing 787 Dreamliner was detected to be faulty.

　　According to the latest poll data, former British Foreign Secretary Boris Johnson is the strongest candidate for the next Conservative Party leader. Hunter, its biggest competitor, said in an interview that if Johnson is elected, the future Brexit will only develop in the direction of "no agreement" or re-holding a referendum.

　　● It is reported that Notre Dame de Paris held a mass for the first time after being ravaged by fire for two months, and all the participants put on safety helmets to avoid being injured by the debris that may fall.

　　● It is reported that Greenland, which has been covered by a lot of ice and snow recently, has experienced an unusual ice melting situation, with about 2 billion tons of ice and snow melting in one day.

　　● Due to the paralysis of the power interconnection system, there was a large-scale power outage in Argentina, and about 48 million people were affected by the power outage. In the capital Buenos Aires, traffic lights stopped running, and public transportation such as subways, intercity railways and buses all stopped. The power outage also affected Uruguay, southern Brazil and some Chilean cities.

　　[hundred States]

　　● Recently, seven donkey friends had an accident in Daxuetang while crossing Wolong National Nature Reserve in Sichuan, and one of the female team members was killed. Official website, the Sichuan Wolong National Nature Reserve Administration, announced on the 16th that the victim died in an accident and the remaining six people were given an administrative penalty of 5,000 yuan.

　　● On June 16th, a bus collided with a car in Anhui. Thirty-two people in the bus and five people in the car were injured to varying degrees. Among them, the passengers in the bus were teachers and students who had just finished the senior high school entrance examination. At present, the local authorities are making every effort to treat the injured, and the cause of the accident is under investigation.

　　● Recently, 17 members of a pyramid scheme criminal gang that restricted the personal freedom of many people and caused the death of a victim were sentenced by the Intermediate People’s Court of Luoyang City, Henan Province according to law. Defendant Wu Banghua was sentenced to life imprisonment, deprived of political rights for life, and fined RMB 100,000.

　　● On the morning of 16th, some netizens posted that a man on Shanghai Metro Line 2 was hit by a train that had not yet been put into operation and died.

　　● On June 16th, the reporter learned from Shantou University that the Li Ka-shing Foundation is the first to promote the full reward program for undergraduate tuition. Undergraduate students from grade 2019 to grade 2022 (including four-year majors and five-year majors such as clinical medicine and stomatology) will receive special scholarships equal to tuition fees, which will reward and support Shantou University undergraduate students in these four grades to complete all undergraduate courses at school.

　　Visual sense

　　● There is a "Star Museum" in a shopping mall in Hohhot. The museum is full of small lights, and the ground and surrounding environment are all glass. Tourists seem to enter the starry sky, attracting many young people to take pictures and play.

　　[sound]

　　● "Indonesia will not become another ‘ World garbage dump ’ ！” — — Indonesia’s Ministry of Environment and Forestry said it had returned five containers of garbage to the United States.

　　● "If you continue training, you will face the risk of recurrence of cancer." — — Li Zongwei, a famous Malaysian badminton player, admitted frankly at the Weibo that he had done his best and had no regrets.

　　[face]

　　● In a gym in Chengdu, 59-year-old Guan Yongkang brings his son Sun Hongwei, who suffers from cerebral palsy, here almost every day. Guan Yongkang said that he will keep practicing with his son, which is his responsibility as a father.

　　See you at 8 o’clock tomorrow!

　　Editor: Xiao Xiao Qian Jingtong

Original Ruijin Infectious Diseases Department Ruijin Infectious Diseases Department

At the 4th Yangtze River Delta Liver Disease Summit Forum and Multidisciplinary Symposium on Diagnosis and Treatment of Liver Tumors in 2020, Professor Xie Qing, Director of Infectious Diseases Department of Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, gave a wonderful report entitled "Risk Assessment and Screening of ——HCC, an urgent problem in the management of chronic hepatitis B in the anti-virus era". The following is a written record.

Professor Xie Qing first introduced a typical clinical case of hepatocellular carcinoma (HCC) after regular follow-up of antiviral therapy for chronic hepatitis B (CHB):

The patient is female, who has been diagnosed with hepatitis B for more than ten years, and her mother and sister have hepatitis B (+), and her sister has a history of hepatitis B liver cancer, and has no other chronic diseases and personal bad hobbies; Liver biopsy was performed after the patient had mild abnormal liver function for the first time, and the result of liver puncture showed that inflammation was grade 3 and fibrosis was grade 2 (G3S2), so entecavir was given antiviral treatment. Patients were followed up regularly for 3-6 months. During the 5-year follow-up of antiviral therapy, low-echo nodules in the left lobe of liver were found by B-ultrasound, with a diameter of about 1.5cm, and AFP was normal. After enhanced MRI and multidisciplinary consultation of liver tumors, HCC was diagnosed and surgically removed. Postoperative pathology showed that hepatocellular carcinoma was grade II-III, with a size of 1.5×1.3×0.6cm, MVI=0, and the surrounding liver tissue showed micronodular cirrhosis, G4S4.

It can be seen from the above cases that after receiving antiviral treatment, patients with early cirrhosis can not completely avoid the risk of HCC even if they maintain high compliance and follow-up regularly to achieve sustained virological and biochemical response.

This brings severe challenges to the management of CHB patients: in the era of antiviral therapy, how should we accurately assess the risk of HCC and standardize HCC screening?

The incidence and mortality of HCC in China are high, ranking the top five in the list of high-incidence malignant tumors in China all the year round, and hepatitis B is the main cause of HCC in China. At present, the prevention and treatment of HCC mainly reduces the global disease burden of hepatitis B HCC through three-level prevention strategies, and combined with hepatitis B cure can further eliminate HCC. At the level of primary prevention, the introduction and implementation of the "small shell" project in China has made 100% of CHB pregnant women with high viral load blocked from mother to child; At the level of secondary prevention, through the management of HBV-infected people without HCC, they can receive antiviral treatment as soon as possible, and optimize the existing antiviral scheme to make more hepatitis B patients cure; At the level of tertiary prevention, the remaining liver function can be improved and the risk of HCC recurrence can be minimized by allowing the radical HCC population to continue antiviral treatment.

A large number of clinical studies have shown that long-term oral administration of NAs antiviral drugs can reduce the risk of HCC, but it cannot completely prevent HCC. The following are data from Japanese and Hong Kong, China population cohorts.

Japanese data:

Hong Kong, China data:

A clinical study from 24 countries shows that obtaining virological response can reduce the progression of liver-related diseases and the incidence of HCC, but there is still a risk of HCC. The research results were published in Clin Gastroenterol Hepatol this year (if = 8.549), and the team of Ruijin Hospital provided nearly 150 cases with a 10-year follow-up cohort.

A 10-year cohort study of Jia Jidong’s team in China showed that the effective inhibition of virus by NAs can significantly reduce the occurrence of HCC, but there is still a high risk of HCC in patients with existing liver cirrhosis, and the cumulative incidence of HCC can be as high as 43.16%.

A nationwide historical cohort study in Korea also aims to explore the risk of HCC in CHB patients receiving antiviral therapy. A total of 24,156 adult CHB patients with newly diagnosed NA were included in the study, and they were treated with ETV (n = 11,464) or TDF (n = 12,692), among which 26.1% and 27.5% were cirrhosis patients in ETV group and TDF group respectively. At the same time, the hospital cohort was used for external verification, including 1560 newly diagnosed adult CHB patients treated with ETV and 1141 patients treated with TDF. The results are as follows.

Xie Qing’s team’s evidence proves that antiviral therapy can reduce the occurrence of HCC, but there is still the risk of HCC after NAs treatment, and PegIFN treatment of CHB is better than NAs (especially for high-risk people) in reducing the risk of HCC. This retrospective study used the published HCC risk scoring system to score each patient, with an average follow-up time of 5.41 years.

Combined with the above clinical research ideas, Ruijin Hospital team has carried out the first prospective intervention study based on high-risk population of HCC in China, which was randomly divided into NAs treatment group and IFN+NAs combination treatment group. The primary/secondary endpoints and research outline are briefly described as follows.

A large number of research data show that antiviral therapy can not completely prevent HCC, so the risk assessment of HCC during HBV infection has become an important proposition. The existing HCC risk prediction models include the evaluation model for patients who have not received antiviral treatment, represented by REACH-B score (Taiwan, China), GAG-HCC score (Hong Kong, China) and CU-HCC score (Hong Kong, China), and the evaluation model for patients who have received antiviral treatment, represented by mREACH-B score (Korea).

CAMD scoring adds diabetes as the basic disease to the traditional scoring rules, which optimizes the application of HCC risk prediction model in high-risk patients.

The latest aMAP score is combined with the patient’s age, sex, bilirubin, albumin, platelet and other indicators to optimize the operation model. The aMAP score of 0-50 is defined as a low-risk group of HCC, and the cumulative incidence of HCC in 5 years is 0.8%. Correspondingly, the score of 50-60 is defined as a medium-risk group, and the cumulative incidence of HCC in 5 years is 4.2%, while the score of 60-100 is defined as a high-risk group.

At present, the HCC screening policies recommended by major international guidelines in the field of hepatology are not the same. Here, Professor Xie Qing makes a clear comb for the participants.

Finally, Professor Xie Qing summarized the diagnosis route of HCC and the crowd management process of different risks of HCC in CHB, based on the major clinical research results, guidelines recommendation and clinical experience at home and abroad, so as to provide reference for clinicians to further guide clinical practice.

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On the evening of March 28th, Country Garden issued an announcement on the Hong Kong Stock Exchange, delaying the publication of 2023 annual results, and the board meeting will also be postponed. In addition, the company will suspend trading on the Stock Exchange from 9: 00 on April 2.

Screenshot from Country Garden’s announcement on the Hong Kong Stock Exchange.

Experts pointed out that since the real estate industry entered the period of deep adjustment, many housing enterprises have encountered liquidity difficulties, and about 40 companies have delayed the release of annual reports. Country Garden delayed the release of its annual performance report, which was expected by the market.

As for the reasons for the delay in publishing the 2023 annual results, Country Garden explained in the announcement that due to the continuous fluctuation of the industry, the business environment faced by the company is becoming increasingly complex, and the company needs to collect more information to make appropriate accounting estimates and judgments, so as to reasonably reflect the changes in the industry and the company in the consolidated financial statements for the year ended December 31, 2023.

At the same time, Country Garden’s debt restructuring is still in progress. In view of the large number and wide distribution of the Group’s projects and the heavy workload and complexity involved in relevant due diligence, more time is needed to collect relevant financial information to carefully evaluate the Group’s current and future financial resources and financial obligations. Country Garden is expected to take longer to complete the preparation of consolidated financial statements as of December 31, 2023, and may not be able to comply with the relevant provisions of the listing rules and publish its 2023 annual results before March 31, 2024.

Country Garden said in the announcement that the Group is working with financial advisers and legal advisers to assess the Group’s situation, and working closely with various creditors to formulate practical measures as soon as possible. In addition, the Board of Directors of Country Garden Group and the management of the company are committed to continuing to actively negotiate with creditors about debt restructuring, and will continue to work closely with the auditor PricewaterhouseCoopers to announce the 2023 annual results and send the 2023 annual report as soon as possible.

According to the listing rules of the Hong Kong Stock Exchange, if the company fails to announce its 2023 annual results before March 31, 2024, the trading of the company’s shares on the Stock Exchange will be suspended from 9: 00 am on April 2, 2024 according to the provisions of Rule 13.50 of the Listing Rules.

The Board of Directors of Country Garden Group believes that the suspension of trading will not have a substantial impact on the company’s operations.

Screenshot from Country Garden’s announcement on the Hong Kong Stock Exchange.

The announcement also revealed the recent situation of Country Garden’s guarantee delivery and debt conversion.

In 2023, Country Garden and its joint ventures and associated companies delivered more than 600,000 houses, with a total delivery area of 71.62 million square meters, covering 249 cities in 31 provinces.

Continue to promote Baojiaolou

According to Country Garden, at present, the company’s domestic security building work and overseas debt restructuring work have been promoted in an orderly manner, and related work has received strong support from stakeholders including relevant local governments and overseas creditors.

As of March 15th, 272 projects under Country Garden have been included in the "white list", distributed in 25 provinces (autonomous regions and municipalities directly under the Central Government), and the amount of financing support has reached 1.732 billion yuan. Other projects that have entered the "white list" are being put in place one after another. Among them, on March 15th, the first batch of "white list" project of Guangzhou real estate coordination mechanism, Country Garden Guangzhou Nanpu Village Project, successfully won the first batch of 50 million yuan loan support from Minsheng Bank, and it is estimated that the annual loan will be 400 million yuan to 450 million yuan.

People close to the company said that the number of short-listed "white list" projects in Country Garden has increased significantly, and the existing projects have been approved by banks, indicating that the efforts of enterprises to actively save themselves and go all out to ensure delivery in the current market environment have been supported and recognized by the government and financial institutions. The "white list" policy of national real estate financing has achieved remarkable results, which is helpful to promote the guaranteed delivery of enterprises.

As of the close of March 28th, Country Garden reported HK$ 0.485 per share, an increase of 1.04%.

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Country Garden’s over 10 billion shares were frozen.

On March 25th, Tianyancha information showed that recently, Country Garden Real Estate Group Co., Ltd., a subsidiary of Country Garden Holdings, added several pieces of information about stock right freezing. The enterprises whose shares were executed included Guangzhou Yuedong Country Garden Investment Co., Ltd., Shenzhen paladin Phase V Equity Investment Partnership (Limited Partnership), Shenzhen Huixin No.22 Investment Consulting Partnership (Limited Partnership), Shenzhen Biji Industrial Development Co., Ltd., etc. The amount of frozen shares ranged from 39 million yuan to 6.705 billion yuan, and the total frozen shares exceeded 10 billion yuan. The enforcement courts were the Intermediate People’s Court of Jining City, Shandong Province and the People’s Court of Linyi Economic and Technological Development Zone, Shandong Province.

According to the data, Country Garden Real Estate Group Co., Ltd. was established in April 2015, and its legal representative is Jian Wentang, with a registered capital of about 15.3 billion yuan. It is jointly held by Foshan Shunde Zhouhua Investment Consulting Co., Ltd. and Shenzhen Bigui Technology Development Co., Ltd. Risk information shows that the shares of several companies held by the company have been frozen before. In addition, the company also has information such as the executor and the consumption restriction order.

In response, Country Garden responded that the equity freeze involved cooperation projects of regional companies. Due to the dispute between Country Garden and the partner in cost calculation and pre-distribution of profits, the partner applied to the court for property preservation. Such disputes are normal commercial disputes, and the court has not yet made a final judgment. The frozen equity value is not the same as the disputed object, and the company is ready to raise an objection to the excessive preservation of the partner.

■ Integrated from Country Garden Announcement

■ Editor: Yue Yue, Zhang Ayi

A: Hello. The Intellectual Property Law Course compiled by the World Intellectual Property Organization (WIPO) WIPO)1988 defines patent documents as: "Patent documents are the general name of published or unpublished documents (or their abstracts) containing the relevant information of research, design, development and test results of discoveries, inventions, utility models and industrial designs, as well as the relevant information of protecting the rights of inventors, patent owners and holders of industrial designs and utility model registration certificates."
　　　　 The above concepts include:
　　　　(1) Patent documents refer to inventions that have been applied for or approved as patents, that is, "research, design, development and test results that have been applied for or confirmed as discoveries, inventions, utility models and industrial designs", and inventions that have applied for patents must be examined and approved by the Patent Office.
　　　　(2) Patent documents refer to the information about the application or approval of patented inventions. It contains not only technical information about "research, design, development and test results of discoveries, inventions, utility models and industrial designs", but also legal information about "protecting the rights of inventors, patent owners and holders of industrial designs and utility model registration certificates", which are documents produced in the process of patent examination and approval.
　　　　(3) Some materials contained in patent documents are published publicly, while others are only for archiving or reproduction. Therefore, patent documents are the general name of the above-mentioned materials and their publications.
　　　　 The course further points out: "Patent literature mainly refers to the official publications of patent offices in various countries according to the general understanding." That is, patent documents mainly refer to the general name of official documents and publications produced by countries and international patent organizations that implement the patent system in the process of patent examination and approval.
　　　　 WIPO standard ST.10 states that the term "patent document" includes invention patent, plant patent, design patent, inventor’s certificate, utility certificate, utility model, supplementary patent, supplementary inventor’s certificate, supplementary utility certificate and their published applications. That is to say, according to general understanding, patent documents as public publications mainly include: various types of inventions, utility models, designs and plant patent specifications, various types of inventions, utility models, designs and plant patent bulletins, abstracts, indexes and related classified materials.
　　　　

CCTV News:During the "Eleventh" holiday, the reporter visited various places and learned that both the new car sales market of new energy vehicles and the second-hand car trading market showed a rising trend. In addition, with the support of a number of favorable policies, consumer enthusiasm continues to rise.

This holiday, Mr. Zhou, who lives in Nanjing, Jiangsu Province, bought a new energy vehicle worth 330,000 yuan, according to "the price of a single vehicle is 300,000 yuan — Mr. Zhou can get a subsidy of 6,000 yuan for the standard of subsidizing 6,000 yuan below 400,000 yuan.

During the "Eleventh" holiday, consumers in Dezhou, Shandong Province can enjoy a one-time subsidy ranging from 3,000 yuan to 6,000 yuan when purchasing new energy passenger cars. In addition, they are exempted from the purchase tax of 4.5% of the car price, the travel tax in 360 yuan, and the replacement subsidy of up to 6,000 yuan and the cash benefit of up to 20,000 yuan given by manufacturers, which makes many consumers feel excited.

Not only the new car market, this holiday, the second-hand car trading market is also stimulated by the policy, and the trading volume has risen linearly. The reporter visited the used car trading market in Huaxiang, Beijing, and learned that the transaction volume of car inspection and transfer has increased by 30%. On October 1 this year, the Ministry of Public Security and other departments issued a policy that when a registered automobile sales enterprise applies for the transfer registration of a small non-operating used car, the public security organ will implement separate endorsement management and issue a temporary license plate. For cities where automobile purchases are restricted, it is clear that used cars purchased by automobile sales enterprises and used for sales do not occupy the number plate index. At the same time, all regions strictly implement the policy of completely canceling the restrictions on the movement of used cars, and cancel the restrictions on the movement of small non-operating used cars that meet the national five emission standards nationwide (including the national key areas for air pollution prevention and control) to promote the free circulation of used cars and cross-regional operation of enterprises.

According to the data of China Association of Automobile Manufacturers, in 2022, the production and sales of new energy vehicles will reach 3.97 million and 3.86 million respectively in the first eight months, up by 120% and 110% respectively.

Tesla CEO elon musk visited Beijing on April 28th at the invitation of China Council for the Promotion of International Trade. During this period, he met with Li Qiang, Prime Minister of the State Council, China. Li Qiang emphasized that Tesla’s growth in China is a model of Sino-US economic and trade cooperation, and reiterated China’s position of opening to the outside world, welcoming foreign-funded enterprises, including Tesla, to enjoy a better business environment and stronger support. Musk spoke highly of Tesla Giga Shanghai’s performance and expressed his desire to deepen cooperation in order to achieve more win-win results.

Tesla officially announced that the company will continue to develop in China, focusing on the fields of artificial intelligence, electric vehicles and energy storage, accelerating the application of clean energy and autonomous driving technology, and turning the vision into reality. Musk’s visit to China was speculated to be related to the promotion of the deployment of Tesla’s fully automatic driving system (FSD) in China, which has not yet officially landed in the world’s second largest market.

The market expectation for Tesla FSD in China is growing day by day, and Tesla also needs this technological advantage to attract more consumers in China. In the face of declining performance in the first quarter and fierce competition from China brands in the field of new energy vehicles, autonomous driving has become the key for Tesla to consolidate its market position. Tesla FSD technology has matured, adopting "end-to-end neural network" technology and training based on massive driving data, which is approaching the edge of large-scale commercial use, indicating a huge potential benefit.

Tesla has set up a data center in China to comply with local data management regulations and ensure that all vehicle data are stored locally. In order to accelerate the popularization of FSD, Tesla recently lowered the subscription and purchase price of FSD in the US market, showing its determination to expand the coverage of this service.

According to industry observation, if FSD can successfully enter China, it will challenge the local autonomous driving scheme and stimulate industry innovation and competition. Tesla’s remarkable advantages in autonomous driving technology, especially the data-driven pure vision scheme, keep it in the leading position even in the face of high-cost fusion sensing technology opponents. With the news of deepening cooperation with Shanghai, Shanghai may become the first place where Tesla FSD is deployed in China, and Tesla’s compliance progress in data processing has also cleared the way for the landing of FSD.

　　Cctv newsAccording to the Central Meteorological Observatory, in the past day, due to the influence of cold air, the temperature in northern Xinjiang and other places dropped significantly, and the local cooling rate exceeded 12 C. It is worth noting that in the next ten days, although there is cold air affecting China, the average temperature in northwest, north China, northeast China, Huanghuai, northern Jianghuai, Jianghan and northwest Jiangnan is still significantly higher than normal.

　　It is expected that in the next three days, due to the eastward movement of cold air, the temperature in northwest China, Inner Mongolia, Northeast China and North China will fluctuate. Today, the temperature in Gansu, northeastern Qinghai, southwestern Ningxia, central and western Inner Mongolia, northern Heilongjiang and other places will drop by 4 ~ 6 C, and the local temperature will drop by more than 8 C.

　　In the next three days, the precipitation in the country is still weak, with small to moderate rain and local heavy rain in the southwest; The Qinghai-Tibet Plateau, Northeast China and other places have frequent snowfall, and some areas in eastern Qinghai and eastern Gansu have heavy snow.

　　With the approach of cold air, the haze weather in central North China and Fenwei Plain will be gradually weakened from north to south from tomorrow. Before that, there were still light to moderate haze in the above areas. In addition, on the 27th, some areas in eastern and southern Xinjiang, western Inner Mongolia, Hexi, Gansu, Ningxia and other places had dusty or dusty weather.

　　Meteorologists reminded that the public in the northern region should pay attention to the adverse effects of strong winds and cooling weather on traffic travel, stay away from areas with high risks such as temporary structures, and pay attention to travel safety. The public in Qinghai-Tibet Plateau and Northeast China should pay attention to the adverse effects of rain and snow on traffic and urban operation, such as slippery roads, icy roads and low visibility.