Since the beginning of this year, in the face of the downward pressure of the economy, all localities and departments have adhered to the principle of stability and progress, coordinated the prevention and control of epidemic situation and economic and social development, and taken various measures to do a good job in stabilizing growth, employment and prices. With the efforts of various policies and the gradual release of policy effects, the normal economic order will be quickly restored and the economic operation will soon return to the normal track.

A few days ago, the macro data of China’s economy was released in April. Affected by the new round of epidemic and the unexpected changes in the international situation, the new downward pressure on the economy has increased. How to treat the current economic situation?

At the online press conference of the National Development and Reform Commission in May, Meng Wei, a spokesperson, said: "At present, the domestic epidemic rebound has been effectively dealt with, and various policies have been put forward and the policy effects have been gradually released. I believe that the normal economic order will be quickly restored and the economic operation will soon return to normal track."

Steady growth-

Effectively coordinate epidemic prevention and control and economic and social development, and strive to stabilize the macroeconomic market.

Faced with the complexity, severity and uncertainty of China’s economic development environment, how to make steady growth work? What are the practical measures to stabilize employment? What are the advantages of stabilizing prices?

Adhere to the principle of stability, strive for progress in stability, and put steady growth in a more prominent position. Effectively coordinate epidemic prevention and control and economic and social development, and various measures are intensively introduced.

Steady investment, macro-policy is in the forefront. From January to April, the National Development and Reform Commission approved 38 fixed assets investment projects with a total investment of 533.3 billion yuan. Among them, 8 fixed assets investment projects were approved in April, with a total investment of 18.8 billion yuan, mainly in the fields of informationization and energy. At present, the quota of local government special bonds used for project construction in 2022 has all been issued. By the end of April, about 1.4 trillion yuan of special bonds have been issued this year.

Smooth circulation, ensure the accessibility of material transportation. In view of the problems in some areas, such as blocked cross-regional logistics and poor port transportation, all localities and departments have made a combination of boxing: eliminating card points, strengthening the monitoring of the traffic situation of expressways and ordinary national highways and the transportation of key materials, and promoting the implementation of a unified national pass system. As of May 16th, the decline of truck traffic in the Yangtze River Delta continued to narrow, and all toll stations and service areas in key epidemic-related areas were opened. Through blocking points, four production materials transfer stations were built in Shanghai, Ningbo and Hangzhou, which played an important role in promoting the resumption of production in key industries such as automobiles.

Reduce costs and effectively stimulate market vitality. While continuing to implement institutional tax reduction and fee reduction to support manufacturing, small and micro enterprises and individual industrial and commercial households, we will improve and optimize the policy arrangements for phased cost reduction and exempt small-scale taxpayers from value-added tax in stages; Give priority to small and micro enterprises’ tax refund, increase tax incentives for innovation of small and medium-sized science and technology enterprises, and guide more funds to flow to key areas and weak links … This year’s cost reduction "spree" combines phased measures with institutional arrangements, inclusive fairness with precise support, with practical measures and great efforts.

Prevent risks and strengthen industrial chain monitoring and early warning. The National Development and Reform Commission guides all localities to establish a risk monitoring and disposal system for the industrial chain supply chain, grasp the emerging risks in a timely manner, and coordinate and solve them in a targeted manner. Especially for key enterprises in integrated circuits and other fields, we should implement daily scheduling and strengthen cooperation to help coordinate and solve the problems faced by enterprises, such as limited return of personnel, poor transportation of raw materials, and suspension of production by suppliers, so as to drive upstream, downstream, large, medium and small supporting enterprises to resume work and production.

"We will thoroughly implement the decision-making and deployment of the CPC Central Committee, intensify macro-policy adjustment, fully expand domestic demand, make precise efforts to expand effective investment, promote the implementation of a number of major projects that are beneficial to both the present and the long term, stabilize market players, and promote enterprises to resume work and reach production as soon as possible under the conditions of epidemic prevention and control, effectively protect and improve people’s livelihood, and strive to stabilize the macroeconomic market." The spokesman said.

Stable employment-

The employment situation continued to be under pressure, and the work of stabilizing employment was implemented in four aspects.

Employment is the foundation of people’s livelihood. Since March, due to the influence of many domestic epidemic spots, wide coverage, frequent occurrence and the more complicated and severe international situation, the difficulties of market participants have increased significantly, and it has become more difficult for some key groups to find jobs, and the unemployment rate in urban surveys has increased. In April, the national urban survey unemployment rate was 6.1%, up 0.3 percentage points from the previous month, and the employment situation continued to be under pressure.

In view of the grim situation and challenges in the field of employment, recently, the CPC Central Committee and the State Council have made many arrangements to study the employment problem, and many departments have introduced relevant measures to do everything possible to stabilize existing employment and actively increase new employment. How to further strengthen the implementation of the employment priority policy? The spokesman said that the implementation of various measures to stabilize employment will focus on promoting four aspects of work.

Guarantee market players and employment. Under the condition of doing a good job in epidemic prevention and control, we will promote enterprises to return to work and reach production. We will speed up the implementation of policies to help enterprises get out of trouble, such as tax refund, tax reduction and fee reduction, and deferred payment of social security fees, make greater efforts to reduce costs, strengthen accurate support for manufacturing, contact service industries, small and medium-sized enterprises and individual industrial and commercial households, further reduce the burden on market players, and help them tide over difficulties and hold their posts.

Promote innovation and entrepreneurship to bring employment. Clean up and remove unreasonable restrictions on employment and entrepreneurship, further enhance the leading role and service capacity of the dual-innovation demonstration base, carry out in-depth demonstration actions of entrepreneurship to promote employment, and enhance the service capacity of the dual-innovation platform. We will strengthen the construction of platforms such as the Pioneer Park and encourage entrepreneurs to start businesses in their hometowns. Support multi-channel flexible employment, strengthen the protection of workers’ rights and interests in new employment forms, and continuously release the kinetic energy of innovation and entrepreneurship.

Grasp key groups and stabilize employment. We will implement the spirit of the Notice on Further Improving the Employment and Entrepreneurship of Young College Graduates and encourage local governments to introduce more support policies. We will further promote the construction of a demonstration park for the integration and development of rural industries, vigorously develop rural industries to enrich the people, actively promote the way of work instead of relief in the field of rural infrastructure construction, and expand local employment channels for farmers.

Talent training strengthens employment support. Deepen the integration of production and education in vocational education, school-enterprise cooperation, and continue to support the construction of pilot cities for improving the quality and quality of vocational education and integrating production and education. Increase support for the construction of public training bases, promote the combination of production and training with high quality, promote the co-construction and sharing of vocational skills training resources, and help carry out large-scale vocational skills training and training.

Stabilize prices-

The supply of industrial and agricultural products and services is abundant, and we will do our best to ensure the supply and price stability of bulk commodities.

Since the beginning of this year, international commodity prices have fluctuated at a high level, and all major economies in the world are facing greater inflationary pressures. In sharp contrast with other major economies, in April, China’s CPI rose by 2.1% year-on-year. Under the pressure of imported inflation, it is not easy for China’s prices to maintain a stable and moderate increase.

"In the face of the complicated and severe external situation, China has coordinated epidemic prevention and control and economic and social development, accurately grasped the rhythm of macroeconomic policies, and continued to do a good job in ensuring supply and price stability of important commodities." The spokesman said that all localities and departments have taken various measures to ensure supply and stabilize prices. Since the beginning of this year, China’s prices have been operating within the overall reasonable range. In April, the core CPI excluding food and energy prices declined steadily, rising by 0.9% year-on-year, and the growth rate dropped by 0.2 percentage points from last month.

Generally speaking, the market supply capacity of goods and services in China is relatively sufficient, and there are many favorable conditions for maintaining price stability.

Food prices are stable and have a foundation. Recently, international food prices have been rising, but the domestic situation has remained generally stable. China’s grain production has been stable at more than 1.3 trillion Jin for seven consecutive years, and its inventory is relatively sufficient. Fu Linghui, spokesman of the National Bureau of Statistics, said that the output of two kinds of rations in China has exceeded the demand for many years, and a small amount of imports are mainly variety adjustment. Corn and soybean have a certain import volume, which will be affected by the international market to a certain extent, but the impact is limited. Since the beginning of this year, China’s grain production situation has continued to improve, and there is a good foundation for maintaining stable grain prices.

The energy supply is stable and secure. China’s oil and natural gas exploitation ratio is relatively high, and the rising price of international energy products will increase the import cost to a certain extent, bring import influence to some industries, and increase the pressure of cost-driven price increase. However, it should be noted that China’s main energy source is coal, while China’s coal reserves are relatively rich and its production capacity is strong. With the gradual release of advanced coal production capacity, it is conducive to curbing the rise in energy prices. In April, China’s coal output increased by 10.7% year-on-year, and the price increase of coal mining and washing industry dropped by 0.5 percentage points year-on-year. The spokesman said that the National Development and Reform Commission will take coal as the "anchor" to do a good job in energy supply and price stabilization, and stabilize electricity prices by stabilizing coal prices, thus stabilizing the overall energy cost.

Most industrial consumer goods have sufficient supply capacity. China has a complete industrial system and strong supporting capacity, and the output of major industrial products is in the forefront of the world, laying a solid foundation for product price stability. The spokesman said that the joint supervision of the spot market will be strengthened with relevant departments, and illegal acts such as fabricating and spreading price increase information, hoarding and driving up prices will be severely cracked down, especially the malicious speculation of capital.

"We will adhere to comprehensive policies and precise regulation, and do our best to ensure the supply and price stability of bulk commodities." The spokesman said that in the later period, China has strong economic resilience, large market space, rich policy toolbox and abundant supply of industrial and agricultural products and services, and is fully qualified, capable and confident to continue to maintain stable price operation. (Reporter Lu Yanan)

Buying a car is for sitting, and comfort configuration plays a very important role. The higher the comfort configuration, the better the consumer experience. I’ll arrange it for you by the way today. Let’s get to know each other.

Let’s take a look at the appearance of Ming Rui first. The design style of Ming Rui’s front has taken a fashionable and dynamic route, and the grille has adopted a three-piece shape, which looks very atmospheric. Combined with the headlights with flamboyant personality, the visual effect coincides with the positioning of the whole vehicle. The car is equipped with LED daytime running lights, automatic opening and closing, delayed closing, rain and fog mode, etc. Coming to the car side, the car body size is 4753MM*1832MM*1469MM. The car adopts eye-catching lines, and the car side presents a comfortable design style. With large-sized thick-walled tires, the overall visual effect is very round. In terms of the rear end, the rear end looks more avant-garde and the taillights look very soft. Overall, it is quite capable.

When you get into the car, the overall visual effect of Ming Rui’s interior is very distinctive and soft. The steering wheel of the car is very in line with the interior style, made of leather and full of design. Let’s take a look at the central control. The car is equipped with an elegant touch-sensitive LCD central control screen, which makes the interior design quite layered, and the overall design of the central control is remarkable. The dashboard and seats are equally eye-catching. The car is equipped with a simple and generous dashboard, and the shape has taken the sports route. The car adopts leather-like seats, equipped with functions such as electric adjustment of auxiliary seats, electric adjustment of seats, and seat proportion tilting, which improves the riding experience of drivers and passengers.

Ming Rui matched the dry dual clutch (DCT) gearbox, with the maximum power of 110KW and the maximum torque of 250N.m, with good power performance.

The car is equipped with driving mode selection, remote control key, interior atmosphere light, engine start and stop, traction control (ASR/TCS, etc.) and other configurations, which fully ensures the convenience and comfort of the car experience.

The Ming Rui introduced today is not only eye-catching in space, but also has reached the mainstream level in various configurations, and there is nothing to be picky about driving experience and space experience. If you are interested, you might as well experience it. I believe it can bring you a good experience.

　　China news agency, Beijing, January 19 (Reporter Liu Yuying) On the 19th, the Ministry of Industry and Information Technology of China released the "Robot Plus" application action implementation plan (hereinafter referred to as the plan), and put forward ten application scenarios.

　　The plan proposes that by 2025, the density of manufacturing robots will double compared with that in 2020, the application depth and breadth of service robots and special robots will be significantly improved, and the ability of robots to promote high-quality economic and social development will be significantly enhanced. Focus on 10 key application areas, break through more than 100 innovative robot application technologies and solutions, promote more than 200 typical robot application scenarios with high technical level, innovative application mode and remarkable application results, and build a number of "robot+"application benchmark enterprises.

　　The top ten key application areas include manufacturing, agriculture, construction, energy, trade and logistics in the economic field, as well as medical health, aged care services, education, business community services, safety emergency and extreme environment applications in the social and people’s livelihood field.

　　For example, in the field of old-age services, the plan proposes to develop robot products for helping the elderly and the disabled, such as disability assistance, bath assistance, toilet care, rehabilitation training, housework, emotional escort, entertainment and leisure, and security monitoring; Actively promote the application verification of exoskeleton robots and old-age care robots in the old-age service scene.

　　The plan proposes to strengthen the basic supporting ability of "Robot Plus" application, which includes: building a collaborative innovation system for robot production and use, building a center for application experience and test verification of "Robot Plus", accelerating the development and popularization of robot application standards, carrying out innovative practice of "Robot Plus" application in industries and regions, and building a docking platform for supply and demand of "Robot Plus" application.

　　The plan also proposes that the human resources and social security departments, together with the robot development and application departments, conduct an assessment of the impact of robots on employment in a timely manner, and promptly promote the affected workers to change jobs. (End)

The style of this car will be very impressive. The front of the new car is equipped with a banner-type chrome-plated air intake grille, which obviously enhances the sense of movement. The design of the headlights on both sides is quite sharp, and it looks very energetic after the headlights are lit. The two waistlines rising through the waistline create a sense of readiness, which looks very sporty. The front end adopts an 18-diameter front wheel, which helps to highlight the shape. Tail line through the use of lines, so that the three-dimensional sense of the tail line is further strengthened, and the details of the taillights have become more powerful after re-sketching.

Coming to the interior, sagitar’s interior style gives people the feeling of simplicity. Because the steering wheel is wrapped with plastic material, it shows young movement in texture and touch. In the embracing center console and the door handle, a lot of soft plastic materials are used to cover and wrap it, which is full of touch and feel. It is equipped with an 8.0-inch LCD screen, which is clear in display and full of technology. The front row is also equipped with manual air conditioning control system, which can freely debug the most comfortable space atmosphere. The suede seat gives passengers just the right support and a soft and comfortable touch.

The length, width and height are 4791×1801×1465mm respectively, and the wheelbase has reached 2731 mm. In the same class, the wheelbase of Sagitar ranks 10th. One bright spot is that its width reaches 1801mm, which reflects that the lateral space inside the car is not bad. Sagitar modified the skylight of 300TSI Double Clutch Excellence Edition to provide a wider field of vision, which can create a better visual environment and good sensitivity for the rear passengers and increase the light intake for the whole vehicle. Among the models of the same price and class, sagitar’s trunk volume ranks second. The shape is very regular, and the storage volume is absolutely no problem for daily use.

Sagitar is equipped with a 1.5 engine with a maximum output of 118kW and a maximum torque of 250Nm. The whole power parameters are superior in power performance among engines of the same class, which can provide better power performance. Sagitar’s official measured zero-acceleration score is 8.8S, ranking 20th among compact car models with more than 800,000.

Sagitar’s active/passive safety configuration is complete, includingAutomatic parking、Zero tire pressure endurance tire、Automatic parking、Steep slope descent、hill start assist control、knee airbag、HUD head-up display、Anti-lock braking (ABS)、Braking force distribution (EBD/CBC, etc.)、Brake assist (EBA/BAS, etc.)、Traction control (ASR/TCS, etc.)、Active noise reduction、Engine start and stop、Side safety air curtain、Wireless charging of mobile phone、night vision system、LED daytime running lights、Forward reversing radar、Tire pressure monitoring、Steering wheel heating、Body stability control (ESP/DSC, etc.)、Rear reversing radar、Fatigue reminder、Remote parking、Child seat interface、Lane keeping (LKAS)Equal configuration.

Among them,Automatic parkingYou can avoid stepping on the brakes for a long time or needing to pull frequently;Steep slope descentCan safely pass through steep slope road conditions at low speed;knee airbagReduce the injury of the car interior to the occupant’s knees in the secondary collision.

If the above data and participation can’t fully understand sagitar, then we can give you a more comprehensive reference based on the word-of-mouth information of users who have purchased sagitar in history. It can be seen that what everyone is most satisfied with sagitar is that its logo is fashionable, and its good appearance and appearance are also the points that everyone likes it.

Shanghai implemented a new round of green smart home appliances consumption subsidy policy from March 30th to December 31st, 2024. For 16 categories of first-class energy-efficient home appliances, consumers enjoy a one-time reduction subsidy at 10% of the transaction price. It is worth mentioning that in addition to traditional household appliances such as air conditioners and refrigerators, computers, printers, air purifiers, rice cookers, microwave ovens, induction cookers, electric fans and water purifiers also entered the subsidy list for the first time.

As a fashion home appliance integrated shopping mall favored by Shanghai consumers, it is understood that Shanghai Red Star Macalline actively participated in it for the first time, and at the same time combed the policy opportunities, and made a detailed analysis of the willingness of brands and merchants to participate in the trade-in action. After careful preparation, it chose to launch the plan on the eve of May 1, aiming at better expanding the effect. Shanghai Red Star Macalline, on the basis of actively participating in the government’s new round of green smart home appliance consumption subsidy policy, has further increased its investment in home appliances for trade-in. On April 15th, 8 shopping malls of Red Star Macalline in Shanghai jointly held the "Launching Ceremony of Electrical Appliances Trade-in and 51 Huanxin Home". The ceremony focused on the direction of intelligence, greening and high-end, promoting quality-for-new consumption and promoting the high-quality development of the industry.

During the event, 8 stores in the same city increased their preferential strength layer by layer. Where consumers go shopping for high-end home appliances in eight offline shopping malls, they can add dual consumption subsidies from the government and Red Star Macalline, with a maximum subsidy of 20% for a single person, totaling 4,000 yuan. In addition, eight stores in the same city officially launched the service of "free disposal of old machines (air conditioners, refrigerators, washing machines and color TVs, etc.), and then enjoy the highest recycling subsidy of 600 yuan", recycling the price and service upgrades, bringing convenience and benefits to users.

Ge Sen, Secretary General of Shanghai Jiaodian Household Appliances Business Association

Ge Sen, secretary general of Shanghai Jiaodian Household Appliances Business Association, said in his speech that the trade-in of household appliances is not only an economic activity, but also an important cause involving resource recycling and environmental protection. He said that Red Star Macalline, as a leading enterprise in the home appliance industry, should not only do a good job in policy propaganda to ensure the fairness and justice of the subsidy policy, but also continuously enhance the supply capacity of products, provide consumers with a reassuring, comfortable and secure consumption experience with the best trade-in service, and promote the upgrading of green smart home appliances to meet people’s yearning for a better life.

Zhao Lei, Vice President of Red Star Macalline Home Furnishing Group and General Manager of Beijing, Shanghai and Shanxi Development Centers.

At the launching ceremony, Zhao Lei, vice president of Red Star Macalline Home Furnishing Group and general manager of Beijing, Shanghai and Shanxi Development Centers, said that Red Star Macalline actively responded to national policies, deepened the trade-in activities of smart home appliances in all directions and dimensions, and really gave subsidies to every consumer with real money. Consumers can not only enjoy the subsidy policy of Shanghai municipal government for household appliances, but also enjoy the "subsidy for upgrading high-end appliances" offered by Red Star Macalline Shopping Mall, so as to realize the "discount" benefit of purchasing high-end household appliances. In order to solve all kinds of troubles in the trade-in of consumers, Red Star Macalline effectively integrates all resources, forms a joint force of trade-in, continuously optimizes the trade-in service link, and provides consumers with a one-stop shopping experience.

From left to right: Yan Jianhui, general manager of Fangtai Group in Shanghai; Zhang Wei, general manager of Shanghai Boss Electric Sales Co., Ltd.; Li Qiang, director of Linnei Electric Shanghai; Luo Jianxi, executive deputy general manager of Shanghai Qizhi Building Materials Co., Ltd. (Wrigley); Dai Hui, director of market operation of Silian China.

The launch of "trade-in of high-end smart appliances" has received strong support from major first-line brands. Fang Tai, the boss and Lin Nei, as representatives of electrical appliance brands, exchanged and shared the old-for-new service at the launching ceremony. In addition to electrical brands, brands represented by mattresses and bathrooms also actively participate in the trade-in activities. All the leading brands said that during this activity, they will come up with the strongest "reserve price", the most affordable promotion and the best quality fashion new products to benefit every consumer who comes to Red Star Macalline Shopping Mall.

The launch of the "Trade-in of High-end Smart Appliances" coincides with the upcoming May Day home consumption peak season. It is understood that Shanghai Red Star Macalline will continue the upsurge of "315 promotion" and will continue to launch a series of promotional measures during the "51 promotion" period to sprint to seize the home improvement market in the first half of the year. 9.9 yuan snapped up the cashback red envelope qualification certificate by scanning the code through the Red Star applet, and returned it to 500 when it was over 5,000, to 1,000 when it was over 10,000, and to 2,000 when it was over 20,000. The maximum amount was 3,500 yuan. (Single-user capping can participate 3 times). In addition, during the event, any customer who buys a brand in the same city can participate in the free-of-charge lottery if the accumulated amount is over 30,000 yuan, or participate in the lottery if the shopping amount is over 5,000 yuan, and the prizes are constantly pleasantly surprised.

As the largest home appliance retail mall in China, Red Star Macalline has been deeply involved in high-end home appliances in recent years and has become the mainstream channel for in-depth strategic cooperation among many international and domestic first-line home appliance brands. Eight Red Star Macalline shopping malls in Shanghai have become the first choice for many consumers to dress up their homes and purchase large household consumer goods with first-class hardware, cost-effective goods and excellent service. With the in-depth development of the "trade-in" activity, relying on the east wind of government subsidies, Red Star Macalline not only provides assistance for the steady promotion of the great economic cycle, but also adds color to consumers’ ideal home life. (Source: Red Star Macalline)

Original Ruijin Infectious Diseases Department Ruijin Infectious Diseases Department

At the 4th Yangtze River Delta Liver Disease Summit Forum and Multidisciplinary Symposium on Diagnosis and Treatment of Liver Tumors in 2020, Professor Xie Qing, Director of Infectious Diseases Department of Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, gave a wonderful report entitled "Risk Assessment and Screening of ——HCC, an urgent problem in the management of chronic hepatitis B in the anti-virus era". The following is a written record.

Professor Xie Qing first introduced a typical clinical case of hepatocellular carcinoma (HCC) after regular follow-up of antiviral therapy for chronic hepatitis B (CHB):

The patient is female, who has been diagnosed with hepatitis B for more than ten years, and her mother and sister have hepatitis B (+), and her sister has a history of hepatitis B liver cancer, and has no other chronic diseases and personal bad hobbies; Liver biopsy was performed after the patient had mild abnormal liver function for the first time, and the result of liver puncture showed that inflammation was grade 3 and fibrosis was grade 2 (G3S2), so entecavir was given antiviral treatment. Patients were followed up regularly for 3-6 months. During the 5-year follow-up of antiviral therapy, low-echo nodules in the left lobe of liver were found by B-ultrasound, with a diameter of about 1.5cm, and AFP was normal. After enhanced MRI and multidisciplinary consultation of liver tumors, HCC was diagnosed and surgically removed. Postoperative pathology showed that hepatocellular carcinoma was grade II-III, with a size of 1.5×1.3×0.6cm, MVI=0, and the surrounding liver tissue showed micronodular cirrhosis, G4S4.

It can be seen from the above cases that after receiving antiviral treatment, patients with early cirrhosis can not completely avoid the risk of HCC even if they maintain high compliance and follow-up regularly to achieve sustained virological and biochemical response.

This brings severe challenges to the management of CHB patients: in the era of antiviral therapy, how should we accurately assess the risk of HCC and standardize HCC screening?

The incidence and mortality of HCC in China are high, ranking the top five in the list of high-incidence malignant tumors in China all the year round, and hepatitis B is the main cause of HCC in China. At present, the prevention and treatment of HCC mainly reduces the global disease burden of hepatitis B HCC through three-level prevention strategies, and combined with hepatitis B cure can further eliminate HCC. At the level of primary prevention, the introduction and implementation of the "small shell" project in China has made 100% of CHB pregnant women with high viral load blocked from mother to child; At the level of secondary prevention, through the management of HBV-infected people without HCC, they can receive antiviral treatment as soon as possible, and optimize the existing antiviral scheme to make more hepatitis B patients cure; At the level of tertiary prevention, the remaining liver function can be improved and the risk of HCC recurrence can be minimized by allowing the radical HCC population to continue antiviral treatment.

A large number of clinical studies have shown that long-term oral administration of NAs antiviral drugs can reduce the risk of HCC, but it cannot completely prevent HCC. The following are data from Japanese and Hong Kong, China population cohorts.

Japanese data:

Hong Kong, China data:

A clinical study from 24 countries shows that obtaining virological response can reduce the progression of liver-related diseases and the incidence of HCC, but there is still a risk of HCC. The research results were published in Clin Gastroenterol Hepatol this year (if = 8.549), and the team of Ruijin Hospital provided nearly 150 cases with a 10-year follow-up cohort.

A 10-year cohort study of Jia Jidong’s team in China showed that the effective inhibition of virus by NAs can significantly reduce the occurrence of HCC, but there is still a high risk of HCC in patients with existing liver cirrhosis, and the cumulative incidence of HCC can be as high as 43.16%.

A nationwide historical cohort study in Korea also aims to explore the risk of HCC in CHB patients receiving antiviral therapy. A total of 24,156 adult CHB patients with newly diagnosed NA were included in the study, and they were treated with ETV (n = 11,464) or TDF (n = 12,692), among which 26.1% and 27.5% were cirrhosis patients in ETV group and TDF group respectively. At the same time, the hospital cohort was used for external verification, including 1560 newly diagnosed adult CHB patients treated with ETV and 1141 patients treated with TDF. The results are as follows.

Xie Qing’s team’s evidence proves that antiviral therapy can reduce the occurrence of HCC, but there is still the risk of HCC after NAs treatment, and PegIFN treatment of CHB is better than NAs (especially for high-risk people) in reducing the risk of HCC. This retrospective study used the published HCC risk scoring system to score each patient, with an average follow-up time of 5.41 years.

Combined with the above clinical research ideas, Ruijin Hospital team has carried out the first prospective intervention study based on high-risk population of HCC in China, which was randomly divided into NAs treatment group and IFN+NAs combination treatment group. The primary/secondary endpoints and research outline are briefly described as follows.

A large number of research data show that antiviral therapy can not completely prevent HCC, so the risk assessment of HCC during HBV infection has become an important proposition. The existing HCC risk prediction models include the evaluation model for patients who have not received antiviral treatment, represented by REACH-B score (Taiwan, China), GAG-HCC score (Hong Kong, China) and CU-HCC score (Hong Kong, China), and the evaluation model for patients who have received antiviral treatment, represented by mREACH-B score (Korea).

CAMD scoring adds diabetes as the basic disease to the traditional scoring rules, which optimizes the application of HCC risk prediction model in high-risk patients.

The latest aMAP score is combined with the patient’s age, sex, bilirubin, albumin, platelet and other indicators to optimize the operation model. The aMAP score of 0-50 is defined as a low-risk group of HCC, and the cumulative incidence of HCC in 5 years is 0.8%. Correspondingly, the score of 50-60 is defined as a medium-risk group, and the cumulative incidence of HCC in 5 years is 4.2%, while the score of 60-100 is defined as a high-risk group.

At present, the HCC screening policies recommended by major international guidelines in the field of hepatology are not the same. Here, Professor Xie Qing makes a clear comb for the participants.

Finally, Professor Xie Qing summarized the diagnosis route of HCC and the crowd management process of different risks of HCC in CHB, based on the major clinical research results, guidelines recommendation and clinical experience at home and abroad, so as to provide reference for clinicians to further guide clinical practice.

Read the original text

The Journey to the Center of the Earth, which is read by ordinary people, has only 142 pages, and the price is only tens of yuan. However, the Journey to the Center of the Earth, which is made into a braille book, is three thick books, and the price needs several hundred yuan. Traditional blind documents are not only expensive, but also many books do not have Braille version … …

A senior student of Chongqing University learned about the difficulties of blind people in "reading" by chance, so he used what he had learned to form a team and innovatively invented "Braille e-books".

Now, through this invention, the technology company founded by Yan Tong has signed an angel round financing agreement of 2 million yuan, and the company is valued at 20 million yuan.

Bookshelf for the blind

A whole shelf holds a book.

Why do you think of doing "Braille e-books"? In August, 2021, during the science and technology training camp during the summer vacation, I met the blind friends of Chongqing Blind Choir.

During a visit to a blind couple’s home, he found a bookshelf full of Braille books in their home. Just as he praised "there are many books in your home", the blind couple told him with emotion: "This whole bookshelf of books is actually just a book, but after being translated into Braille, it has become so many books … …”

I was shocked. Through detailed understanding, he found that he originally bought a small book "Journey to the Center of the Earth" with only 142 pages on the Internet, but after it became a Braille book, there were three big books, which cost several hundred yuan to buy. The "cost" of blind reading is dozens of times that of ordinary people. And many books that blind people want to read can’t buy blind documents at all.

Although blind people can also read by listening to books, listening to books and reading books are completely different feelings. The process of "listening to a book" is fleeting, and only by "reading a book" can we enjoy the beauty of the text, and we can have a aftertaste through "repeated reading". When learning knowledge, there is no way to complete it by "listening to books".

After returning to school, I looked at the e-book "kindle" used by my friends, and I couldn’t help but think: "Can I make a ‘ Braille kindle’ ? Let the blind read whatever books they want. "

"One book" and all books

In December, 2022, together with three like-minded students, Tan Tan started the research plan of "Braille e-books". Of course, the first difficulty they encountered — — No money.

However, opportunities are always reserved for those who are prepared. After reporting their ideas and plans to the College, Tan Tan got the support of the College. After the approval of the College Project Committee, they got the first start-up capital of 50,000 yuan.

Since we want to make a Braille e-book, we must first understand the needs of the blind. At the beginning of the launch, Tan Tan and his team went to the special education school in Nan ‘an District for investigation, and attended classes with the children there for many days.

"The more you know, the more you feel, and understand that you are doing a very meaningful thing!" Tan Tan said that after seeing with his own eyes the difficulties and desires that blind children face in reading, they began to change their original ideas.

After the investigation, Li Zekun, a software engineer in the team, said to Tan Lian, "I started as a project, and now I really want to do something for them … …”

Design, manufacture and improvement … … With the joint efforts of the team, it took only three months to produce the first version of the Braille e-book in February 2023.

This e-book is shaped like a tablet computer without a screen, and it is full of rows of Braille characters. It can not only read existing Braille e-books, but also transcode a large number of books into Braille through software.

Tear everything down and start over.

After the first finished product was made, Tan Lian sent it to the blind couple he knew for trial, and the other party gave comments and suggestions after a period of trial.

"The good thing is convenience. There are many books to read in the e-book, but there are still many details to be done." For example, in Braille reading, the distance between the two "dots" that make up Braille should be less than 2.5mm, so as to achieve the best reading experience, but the distance between the "dots" in the first version of the e-book is 3 mm.

Although this product can also be used, it is not so perfect.

After receiving the feedback, Tan Tan and the team’s friends held a meeting to discuss, and there were two choices before us: because of technical reasons, the first edition of the e-book was difficult to improve, and although it could barely meet the requirements after improvement, if you want to give the blind the best reading experience, then everything needs to be reinvented.

So, after discussion, everyone agreed to start over and start the struggle again.

Starting a business while attending classes will bring great pressure to people. "At that time, we often gathered in the laboratory at 9 o’clock in the morning and left at one or two o’clock in the evening." Yan Yan said with emotion, especially in junior year, there are many courses and great academic pressure, so I can only "squeeze and squeeze" my time.

In this process, some graduate students left and some new teammates joined. Everyone encouraged and helped each other and worked together for the common goal. During this period, Chongqing Unbounded Qihang Innovation and Technology Co., Ltd., founded by Yan Tong, successfully obtained the incubation fund of 500,000 yuan from Mingyuehu International Intelligent Industry Science and Technology Innovation Base in Liangjiang New District of Chongqing, and also moved its office to Mingyuehu.

His goal is coming true!

As a student of the National School of Excellence Engineers of Chongqing University, Tan Tan studied in the experimental class of Mingyue Kechuang.

"The school has given us a lot of help, and our courses are mainly project-driven." According to the introduction, the school itself is also training everyone in the direction of industrial innovation practice. One of the courses that impressed him deeply is to let the students make a boat and meet the requirements of tilting 120 degrees without overturning.

The learning method of combining theory with practice has been improving his ability to use his hands and brains. During the start-up period, Tan Lian won 6 national awards, 6 provincial and municipal awards, 7 invention patents, 2 utility model patents and 1 software copyright as the first inventor.

"I first met you in the lab, and later I learned about his entrepreneurial project, which was very challenging, so I joined in with the recommendation of my tutor." Cao Xiuxiu, a mechanical engineering major at Chongqing University, said that after joining the team, especially after really understanding the reading difficulties of the blind, she quickly found the "goal" to fight for, and worked hard with everyone towards this goal. In the process, she was also full of gains.

After more than a year of fighting day and night, in February 2024, the second brand-new version of "Braille e-book" independently developed by the team finally took out the sample. This version of "Braille e-book" is smaller, lighter and more convenient to read. It is the best in all aspects, which makes the trial blind people fondle it. It is expected to be launched in the second half of 2024.

"In this small e-book, Dream of Red Mansions and Romance of the Three Kingdoms … … All kinds of literary works can be blind ‘ Look ’ See! " He said happily.

Help more blind people to read and see a wider world in books.

This dream, he is about to achieve!

Upstream journalist Song Jian Zhang Jinqi

　

Securities code Securities abbreviation Latest price Last week’s ups and downs Up and down this month Up and down this year 52-week ups and downs 01860 Huiliang technology 9.05 hong kong dollars 13.13% 13.13% 212.07% 213.15% 08083 Youzan HK$ 0.11 13% 13% -21.53% 10.78% 00136 China’s Confucianism 2.20 hong kong dollars 7.32% 7.32% 27.17% 19.57% 09626 Mile mile -W HK$ 150.70 1.14% 1.14% 61% 61.26% 01948 Youju holding 1.06 hong kong dollars 0% 0% -45.08% -42.39% 01024 Aauto Quicker -W HK$ 47.60 -1.24% -1.24% -10.1% -11.61% 03700 Reflect the universe 1.91 hong kong dollars -2.05% -2.05% 130.12% 122.09% 06988 Lexiang group 0.10 Hong Kong dollars -3.7% -3.7% -54.59% -68.48%

　　● Talk about the COVID-19 epidemic and the "great change that has never happened in a hundred years"

　　In the past few days, it has been worrying to see Italy, Europe and the world. The COVID-19 epidemic is spreading rapidly around the world, which is a major disaster affecting the whole world. No matter in which continent or country, the lives lost due to illness are regrettable and sad.

　　China has stepped out of the most difficult stage in fighting the epidemic. This is not Covid-19’s leniency towards Chinese — — But because China mobilized the whole country to fight the epidemic, and resolutely implemented a set of anti-epidemic measures that proved to be in line with China’s reality and scientific laws.

　　The COVID-19 epidemic will profoundly change the world today and be written into human history in a heavy way. It is on the rampage, but in the face of appropriate, powerful and tenacious response, it will also temporarily decline and retreat.

　　This conforms to the law that has been presented for thousands of years — — Plague often rewrites human history, but it is not arbitrary.

　　In a sense, the history of the development of human civilization is the history of constantly fighting against epidemics. Infectious diseases are the product of the interaction between microorganisms and human beings. For thousands of years, plague has been entangled with human society too much. From the results, there are at least three ways to present:

　　One is to brutally hurt people and kill them. Before human society entered industrial civilization, the lethality of plague was extremely amazing — — Whether in ancient Greece, Rome, or medieval Europe, or in the American continent and Asian continent where early colonists set foot. A plague can last for dozens, hundreds, hundreds of years, or even destroy the country, or take away 30% to 40% of the lives of a continent.

　　The second is to become a force to change the direction of civilization. Plague broke out during the Peloponnesian War, which caused heavy losses to ancient Greek civilization. Plague once shook the foundation of the Roman Empire. The Black Death plunged medieval Europe into darkness. Smallpox once landed with the colonial fleet and merchant fleet and disturbed the American continent. Cholera traveled to many continents in the 19th century, which caused a sudden loss of national strength of many powerful countries.

　　Third, human beings are constantly creating new civilizations in the struggle against the plague. It is recorded in the History of Han Ping Di Ji that in the second year of Yuan Dynasty, "people who suffer from diseases and epidemics give up their empty houses to buy medicine", which is the law of "isolation". Europe also uses isolation and quarantine to fight the Black Death. China used human pox to prevent smallpox in the Ming Dynasty. After entering industrial civilization, antibiotics, vaccines, etc. have gradually entered the battlefield. In the past century, it is in the unremitting struggle against the plague that many international organizations and institutions related to public health have been established.

　　One hundred years ago, at the end of World War I, the Spanish pandemic broke out. This epidemic disease is named after a place name, which is no longer in line with today’s international practice. It was just an established practice that year, leaving a helpless mark. Today, in the rules of the World Health Organization, it has been clearly stated that diseases should not be named after place names. Since the second world war, human beings have suffered many epidemics that spread all over the world. Fortunately, the degree of injury is not an order of magnitude before industrial civilization. It is not because the virus has weakened, but because human means have become stronger.

　　Every time there is a global epidemic, no matter how tortuous the process is, in the final analysis, it is to fight two things — — First, science and technology, which is the ultimate weapon to win; The second is the ability of social organization, which is the key to control the epidemic, reduce losses and win time for scientists.

　　Covid-19 is a fierce public enemy of mankind. It is secretive and cunning. How lethal it is has not yet peaked. At present, the outbreak caused by it is not only fatal and harmful, but also beyond the scope of biological damage to life, and is bringing great impact on global economy, politics and social life, and profoundly affecting the whole world pattern.

　　In recent years, General Secretary of the Supreme Leader has repeatedly expounded a major judgment — — "The world is facing a great change that has never happened in a hundred years". In particular, he stressed the need to focus on this "big change", focus on preventing and resolving major risks, and pay attention to turning crises into opportunities. In January 2018, at the opening ceremony of the seminar on studying and implementing the spirit of the 19th National Congress of the Communist Party of China, he listed 16 specific risks in eight aspects, among which it was mentioned that "major infectious diseases like SARS should always be vigilant and strictly guarded".

　　Under the general judgment that "the world is facing a great change that has never happened in a hundred years", in recent years, many people from all walks of life have understood and analyzed it, and most of them have started from the rapid development of scientific and technological revolution, the historical decline of western centralism, the accelerated growth of emerging forces, and the major challenges faced by global governance. Undoubtedly, these are all components of the rich connotation of the "great change".

　　Too many people didn’t expect that at the first moment when mankind entered the 1920s, Covid-19 was killed in Xiecili, and the epidemic suddenly broke out and spread all over the world. Many countries with serious epidemics have to do their best to fight it. The public health emergency response capacity of all countries, as well as the organization and mobilization capacity of the whole country, has been tested. The world economy, which is already under downward pressure and transformation pressure, has also sharply increased uncertainties.

　　Virus risk, epidemic risk and governance risk are intertwined. It can be said that the "great change in a hundred years" is showing its realistic complexity and full historical depth from the perspective of outbreak and resistance to the pandemic.

　　When we want to consolidate the domestic anti-epidemic achievements and try our best to support the global anti-epidemic, when we "sum up experience and learn lessons" in time and constantly improve the national governance system and governance capacity, there is no doubt that we should stand on the height of understanding that the world is facing a great change in a hundred years, full of self-confidence and sense of urgency, and make thinking, planning and launching actions.

　　(Wen Wei special commentator Yang Wei)

Hangzhou Municipal Bureau of Commodity Price Hangzhou Health and Family Planning Commission
Notice on Issuing the Opinions on Strengthening the Management of Medicine Price in Non-public Medical Institutions in Hangzhou

Hangjiafu [2014] No.161

District, county (city) Price Bureau, Health Bureau and non-public medical institutions:
　　In order to strengthen the medical price management of non-public medical institutions, standardize the medical price behavior, safeguard the legitimate rights and interests of patients and non-public medical institutions, and further promote the healthy development of non-public medical institutions, According to the National Development and Reform Commission, the National Health and Family Planning Commission, Ministry of Human Resources and Social Security’s Notice on Issues Related to the Implementation of Market-regulated Prices for Medical Services in Non-public Medical Institutions (No.503 [2014] of the Development and Reform Commission), Opinions of the People’s Government of Zhejiang Province on Promoting the Accelerated Development of Private Medical Institutions (No.46 [2013] of Zhejiang Province), The Zhejiang Provincial Price Bureau’s Notice on Standardizing the Clear Price of the Medical Industry in the Province (Zhejiang Price Inspection [2001] No.463) and other documents, combined with the actual situation of our city, formulated the Opinions on Strengthening the Management of Pharmaceutical Prices in Non-public Medical Institutions in Hangzhou, which has been legally reviewed and agreed by the municipal government, and are hereby printed and distributed to you, please follow them.

Hangzhou bureau of commodity price
Hangzhou Health and Family Planning Commission
September 9, 2014

Opinions on strengthening the management of medicine price in non-public medical institutions in Hangzhou

　　In order to strengthen the medical price management of non-public medical institutions, standardize the medical price behavior, safeguard the legitimate rights and interests of patients and non-public medical institutions, and further promote the healthy development of non-public medical institutions, According to the National Development and Reform Commission, the National Health and Family Planning Commission, Ministry of Human Resources and Social Security’s Notice on Issues Related to the Implementation of Market-regulated Prices for Medical Services in Non-public Medical Institutions (No.503 [2014] of the Development and Reform Commission), Opinions of the People’s Government of Zhejiang Province on Promoting the Accelerated Development of Private Medical Institutions (No.46 [2013] of Zhejiang Province), The Zhejiang Provincial Price Bureau’s Notice on Standardizing the Clearly Marked Price of the Medical Industry in the Province (Zhejiang Price Inspection [2001] No.463) and other documents, combined with the actual situation of our city, are hereby notified as follows to strengthen the medical price management of non-public medical institutions in Hangzhou:
　　First, the price of medical services provided by non-public medical institutions shall be regulated by the market. Non-public medical institutions that are profit-making can set up medical service items and set specific prices by themselves; Non-public medical institutions, which are non-profit, set up service items and set their own specific prices in accordance with the National Specification for Medical Service Price Items. Drug sales shall implement the prescribed price policy.
　　 Non-public medical institutions participating in the comprehensive reform of public hospitals shall be implemented in accordance with the current medical service price and drug price policies.
　　Two, strengthen the dynamic monitoring of drug prices in non-public medical institutions. Non-public medical institutions should provide medical service items and charging standards and other information to the competent price department and health department where the "Practice License for Medical Institutions" is registered; To increase the charging items of medical services and adjust the price of medical services, the relevant information should be submitted to the competent price department and the competent health department in the place where the "practice license of medical institutions" is registered in time, so as to facilitate the dynamic monitoring of prices and the guidance and supervision of price behavior.
　　Three, non-public medical institutions should do a good job in the publicity of medical prices according to regulations.
　　(a) should be eye-catching position in its service place according to the following requirements to do a good job of medical price publicity:
　　The commonly used items and prices of medical services and the prices of commonly used drugs are prominently publicized in the executive department and the toll collection office.
　　The outpatient hall and inpatient hall should be equipped with a touch computer inquiry system in a conspicuous position for patients to inquire about the detailed medical prices of medical institutions. Smaller medical institutions are temporarily unable to set up a touch computer inquiry system, which can be publicized in other ways.
　　The information desk or medical guide desk should be equipped with a detailed medical price manual for patients to inquire.
　　(2) The publicity contents of common medical services include project name, project connotation, excluded contents, pricing unit, price, etc.; The contents of common drug price publicity include drug name, dosage form, specification, pricing unit, manufacturer, retail price, etc.
　　(3) establish a cost list system to provide patients with a list of expenses such as medicine.
　　Outpatients shall be provided with a list of outpatient charges. The detailed list of outpatient charges shall indicate the name, date, specific name and amount of expenses, and the name, specification, pricing unit, amount and total amount of medicines.
　　Daily hospitalization expenses list and summary list of hospitalization expenses categories shall be provided for inpatients. The list of daily hospitalization expenses should indicate the name, date, name and amount of expenses and the name, specification, pricing unit, quantity, amount and total amount of drugs; The summary list of hospitalization expenses should indicate the name, date of hospitalization, date of discharge, number of days, cost items, amount and total amount of expenses.
　　Four, non-public medical institutions should strengthen price management, set up a price management team, establish and improve the internal price management system.
　　(1) Set up a price management team. The price management team is composed of the heads of medical institutions, price management departments and full-time (part-time) price clerks, and is responsible for guiding, coordinating and supervising internal price management. The main responsibilities are as follows:
　　1 to implement the government’s medical price policy, implement the responsibility system for medical price management, and carry out price management according to law;
　　2. Guide, coordinate and supervise the relevant departments within the unit to correctly implement the drug price policy;
　　3. When the price of medicine changes, it should be adjusted and publicized in time;
　　4. Accepting medical price consultation and handling medical price complaints;
　　5. Regularly or irregularly conduct self-examination and self-correction on the implementation of medical prices in this unit to stop irregular price behaviors;
　　6 to assist and cooperate with the competent departments of price and health to carry out law enforcement inspection.
　　(2) Establish and improve the internal price management system. Establish and improve the internal medicine price adjustment and pricing management system, standardize pricing procedures; Establish a medical service cost accounting and cost control system, reasonably determine the medical service price level, and keep the price level relatively stable for a certain period of time.
　　(three) the establishment of medical price complaint management system. Set up a medical price complaint box in a prominent position in medical institutions, and announce the complaint telephone number to the public, and consciously accept social supervision; Seriously receive and accept patients’ complaints about price consultation, and solve existing problems in time.
　　Five, health administrative departments at all levels should promptly publish and adjust the list of public medical institutions within their respective jurisdictions, and all medical institutions outside the list are non-public medical institutions.
　　Price and health authorities at all levels should strengthen policy guidance to non-public medical institutions, not only promote the development of non-public medical institutions through price leverage, but also regulate their price behavior according to law to safeguard the legitimate rights and interests of patients.
　　This notice shall be implemented as of November 1, 2014. The Notice of the Municipal Price Bureau on Strengthening the Management of Pharmaceutical Prices in Private Medical Institutions in Hangzhou (Hangzhou Price Service [2011] No.263) shall be abolished at the same time.