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　　Xinhua News Agency, Moscow, December 10th(International observation) The dawn of Russian-Ukrainian peace talks is still hard to see under the western "fatigue"

　　Xinhua News Agency reporter Zhao Bing

　　In the past, the conflict between Russia and Ukraine continued, and Ukraine’s continuous counterattack failed to effectively break through the Russian defense line. With the coming of the severe winter, the war is at an impasse. At the same time, western countries began to "feel tired" of helping Ukraine, and there were rumors that Russia and Ukraine had secretly started negotiations.

　　Analysts believe that despite the "Ukrainian fatigue" in the West, there is still a willingness to continue to support Uzbekistan. Due to the fundamental differences between Russia and Ukraine in terms of negotiation conditions and peace vision, the prospects for negotiations between the two sides are still slim, and there is no dawn of restoring peace in the short term.

　　The war is deadlocked.

　　Recently, the conflict between Russia and Ukraine has continued to drag on, and the battlefield situation has been deadlocked. Russian troops continued to block the Ukrainian offensive in Kupiyansk, Hongliman, Donetsk, Hellson and Zaporoge. The Ukrainian army, on the other hand, has been forced to turn from active attack to defense since late October due to the unfavorable progress of the summer counterattack and the reduction of western aid. The two sides began to use long-range weapons such as missiles and drones to launch attacks more frequently.

　　According to the Russian notification, from December 3 to 8, the Russian army used high-precision weapons and drones to carry out 30 cluster attacks on Ukrainian arsenals and other facilities, and also attacked Ukrainian armed forces and foreign mercenaries. In a week, the Ukrainian army lost more than 1,400 people and 1,500 people respectively in the direction of Hongliman and Donetsk, and dozens of armored vehicles and artillery were destroyed, and five planes and 224 drones were shot down.

　　According to Ukrainian media reports, since November, key facilities in Kiev, the capital of Ukraine, and many places in the west and south have been continuously attacked by Russian drones. At the same time, the Ukrainian army has stepped up its air strikes against Crimea in the past month, aiming at reconnaissance and collection of Russian military information to launch a larger-scale operation. In addition, the Ukrainian military said that the Russian army assembled more than 40,000 soldiers to attack Avdeev Card, an important town in Donetsk, which suffered serious losses, but the offensive continued unabated.

　　Russian Defense Minister shoigu said a few days ago that the Ukrainian army has lost more than 125,000 people and 16,000 weapons and equipment in the so-called counter-offensive in the past six months, and the "desperate actions of Ukraine and the West have not changed the battlefield situation". Zaluzhnyi, commander-in-chief of the Ukrainian armed forces, admitted in an interview with The Economist that the conflict was "deadlocked, which may last for several years", and that the Ukrainian army could not break through the Russian defense line and was "in fact in trouble".

　　The spread of "fatigue" in the west

　　As the battlefield situation continues to stalemate, "Ukrainian fatigue" is spreading in western countries.

　　The United States is the main supporter of Ukraine, but after the outbreak of the new round of Palestinian-Israeli conflict, the United States’ great military aid to Israel diverted its aid to Ukraine. Domestic partisan strife has also affected US aid to Ukraine. On the 6th, the US Senate failed to pass the White House’s application for special funding including more than $60 billion in aid to Ukraine.

　　According to a recent report released by the Kiel Institute for World Economics in Germany, from August to October 2023, western countries promised a total aid plan to Ukraine of 2.11 billion euros, a decrease of 87% compared with the same period in 2022 and the lowest since January 2022. The report said that there are great uncertainties in the aid plans of the European Union and the United States.

　　The EU will hold a summit from 14th to 15th to vote on the 50 billion euro aid plan for Ukraine, but EU officials said that it is "very, very difficult" for member countries to reach an agreement. Hungarian Prime Minister Orban openly opposed the aid plan to Ukraine and the EU’s initiation of Ukraine’s accession negotiations. Slovakia’s new Prime Minister Fizo also explicitly opposed military assistance, saying that he was only willing to provide humanitarian assistance to Ukraine. Polls in Poland show that people are tired of aiding Ukraine, and the relationship between Poland and Ukraine is also cracked due to the ban on food imports from Ukraine. Italian Prime Minister Silvio meloni, despite publicly expressing her stance against Ukraine, admitted in a prank phone call that all parties were "tired" of the Ukrainian crisis.

　　Nevertheless, aid to Ukraine is still "politically correct" in the west, and some countries still have strong willingness to aid Ukraine and are trying to strengthen its military production capacity. The United States recently signed a military cooperation agreement with Ukraine for joint production and technology sharing. Rheinmetall plans to establish an armored vehicle production line in western Ukraine by the end of this year.

　　In addition, U.S. Secretary of State Blinken publicly stated on the 7th that U.S. military assistance to Ukraine is beneficial to the U.S. economy. In this regard, Timofei Bordachev, project director of Valdai International Debate Club, a Russian think tank, believes that the West should not be expected to reduce or even interrupt its aid to Ukraine.

　　The peace talks are temporarily difficult

　　Seymour Hirsch, a well-known American investigative journalist, recently revealed that the Russian-Ukrainian peace talks led by gerasimov, Chief of Staff of the Russian Federation Armed Forces, and Zaluzhnyi, Commander-in-Chief of the Ukrainian Armed Forces, seem to have started. According to Hirsch, the conditions for restoring peace that the two sides are negotiating may include that Ukraine can join NATO, but NATO promises not to deploy troops and offensive weapons in Ukraine, while Russia will keep Crimea, Donetsk and Lugansk. Part of the territory.

　　In this regard, some Russian experts pointed out that it is impossible for Russia to accept such a transaction and will not believe NATO’s above commitments. Some Russian experts believe that this may be an information war between Ukraine and the West. Senior officials, such as Podolyak, adviser to the President’s Office of Ukraine, publicly stated that the topic of negotiations should not be hyped, the Russian side has not changed its goal, and Uzbekistan’s position has not changed.

　　Analysts generally believe that the exchange of prisoners between Russia and Ukraine shows that there are communication channels between the two sides. However, due to the fundamental differences in the conditions for resuming peace talks and the vision for the future peace order, the prospects for resuming peace talks between the two sides are still slim.

　　Jonathan Finn Na, Deputy Assistant to the President of the United States for National Security Affairs, said publicly a few days ago that the United States hopes to force Russia to negotiate according to Ukrainian conditions within 2024. In this regard, peskov, Russian Presidential Press Secretary, bluntly said that the remarks that Russia can negotiate according to Ukrainian conditions are "totally unrealistic". Ambassador-at-large of Russian Foreign Ministry Rodion Miroshnik also said that the key issue is whether Ukraine and the West are really ready for negotiations. He said that at least for now, Russia will continue to work hard to achieve the goal of special military operations. (Participating in reporters: Li Dongxu, Zhang Zhang, He Fei, Wang Lili, Deng Xianlai)

　　On October 14th, a cartoon short film "How Leaders Are Tempered" was broadcasted on the Internet. The Supreme Leader appeared as a cartoon for the first time, introducing the selection mechanism of China leaders through his promotion. The Seventh Standing Committee of the Political Bureau of the Central Committee and former national leaders such as Mao Zedong, Deng Xiaoping, Jiang Zemin and Hu Jintao also appeared as cartoons in the film. The Chinese version of the short film went online for 3 days, and the broadcast volume exceeded 1.2 million.

　　How are the leaders of the United States, Britain and China tempered?

　　The short film introduces the changes in the assessment standards of leading cadres in China, emphasizing that leading cadres should go through many tests and accept supervision from all sides.

　　"How Leaders Are Tempered" is more than five minutes long, in which American President Obama, British Prime Minister David Cameron and the Supreme Leader of president, China are taken as examples to introduce the different mechanisms of the leaders of the three countries. In the short film, the leaders all appear in cartoon shapes made of real people’s heads. The pictures are humorous and interesting, and the introduction language is relaxed and humorous, which is quite popular among netizens. Some netizens commented: "Who said that the image of a leader must be serious? Why can’t it be replaced by a more relaxed and humorous image? "

　　In addition to comparing the different mechanisms of the leaders of the three countries, the short film also introduces the changes in the assessment criteria of leading cadres in China, and emphasizes that leading cadres in China have experienced many tests and accepted supervision from all sides: "At present, in China, the discerning eyes of 538 million netizens make problem cadres have nowhere to hide and be eliminated."

　　The short film was originally uploaded by "Fuxing Road" at 12: 06 on October 14th, and it was divided into two versions, Chinese version and English version. By 18: 00 yesterday, the number of hits reached 1.26 million, and the number of hits in English version was more than 8,000. It is understood that 1.2 million hits are record-breaking in this kind of political video clips, and the previously popular "Foreigners Teach You to Understand China in Ten Minutes" has only been played less than 70,000 times.

　　What kind of political path does the supreme leader take?

　　At least 16 major job adjustments were made, and it took more than 40 years before and after.

　　A short film of more than 5 minutes, and the content related to China is nearly 4 minutes. The short film begins with 1 minute and 23 seconds to introduce the emergence of China president, in which the cartoon image of the supreme leader appears three times, the longest lasting 23 seconds and the shortest only 4 seconds.

　　The short film said, "To become president in China, you should also become the leader of the ruling party", and pointed out that to become the leader of the 85 million party member organization in China needs decades of continuous selection and testing. The short film goes on to say that it takes an average of at least 23 years to get from a low-level grassroots party member to a ministerial-level cadre, but the chance of becoming a ministerial-level cadre among more than 7 million cadres is only one in 14,000.

　　At 2 minutes and 37 seconds, the cartoon image of the supreme leader appeared, ending at 3 minutes and lasting for 23 seconds. The short film takes the supreme leader in president, China as an example, saying that the supreme leader has gone through at least 16 major job adjustments from the grassroots level in China, which is equivalent to the community in Europe and America, to the top leaders in several provinces (cities) such as Fujian, Zhejiang and Shanghai, to the vice president of the country, and then to the general secretary of the Party and president. This process took more than 40 years. "The new leadership team born in the 18th National Congress of the Communist Party of China (CPC) in 2012 has all stepped up step by step."

　　At 3 minutes and 26 seconds, the cartoon image of the supreme leader appeared again, passing through different scenes such as data charts, inspection sites and the Great Hall of the People, indicating that through the previous selection process, "before party member became a leader, he had fully understood China’s national conditions and people’s feelings from the bottom up, experienced the tests and exercises of various urgent and dangerous tasks, and more importantly, he had participated in the discussion and formulation of many major strategies and policies at various levels."

　　At 4 minutes and 40 seconds, the cartoon image of the supreme leader reappeared for 4 seconds. It was illustrated in the animation form of jumping steps that the generation mechanism of China leaders was "China Kung Fu"-style long-term exercise and selection of talents and abilities.

　　However, in the end, the short film said, whether it is the vote of the United States in World War I or the long-term exercise of "China Kung Fu", "As long as the people are satisfied, the country develops and the society progresses, this road is right, isn’t it?"

　　Who is the producer on the road to revival?

　　Most netizens believe that it is unlikely for ordinary netizens to upload, and it should be an official production.

　　Where does this interesting short film come from? Is it made by netizens independently or officially? While the network caused a hit, the source and producer of the short film "How Leaders were Tempered" also caused many conjectures among netizens.

　　Among the comments at the bottom of the short film, most netizens thought it was made by the government, "with vivid and interesting form and strong affinity", and netizens thought it was an improvement of government propaganda, "at least it would cater to the public’s taste". Some netizens interpreted it from the short film producers and thought that "from the signature point of view, it may be released for the official low-key."

　　At the end of the short film "How Leaders Are Tempered", the logo of "Studio on Fuxing Road" was printed, and the uploading nickname of this short film was also "Fuxing Road". Beijing Youth Daily reporter found that the account only uploaded two short films, that is, the Chinese and English versions of How Leaders were Tempered, and there was no other operation. The registered address of the account is Beijing, showing that the gender is male.

　　Some netizens speculated from the nickname "Road to Rejuvenation": "In 2012, 15 days after the new Standing Committee took office, it was the first time to go out of Zhongnanhai to visit the exhibition" Road to Rejuvenation ". Therefore, it is more likely that the short film will come from the government.

　　In addition, some netizens commented that in China, leaders’ images are mostly real people in news pictures, and leaders’ cartoon images should be censored, so it is unlikely for ordinary netizens to upload them.

　　(Reporter Zou Chunxia)

　　memory

　　How long does it take from an official party member to the Politburo Standing Committee?

　　According to the current promotion system for cadres of the Communist Party of China, undergraduate graduates enter the civil service system as clerk at the beginning, and the requirements for promotion to deputy, deputy, deputy hall and deputy ministerial level positions have been held at the next level for more than three years, and the requirements for promotion to full-time, full-time and main-level positions have been held at the next level for more than two years. According to the regulation of step-by-step promotion, the minimum time for undergraduate graduation to be promoted to a deputy ministerial position is over 18 years, and the youngest should be over 40 years old.

　　According to the detailed promotion data of 25 members of the Political Bureau of the Communist Party of China Central Committee, the average years for them to be promoted to the official rank is 9.36 years, from the official rank to the official rank is 4.72 years, from the official rank to the vice-ministerial rank is 5.60 years, and from the vice-ministerial rank to the official rank is 8 years, which means that it takes an average of 19.68 years from the grass-roots level to the vice-ministerial rank and 27.68 years to the official rank.

　　According to the statistics of Phoenix Weekly, there are seven The Politburo Standing Committee (PSC) who took up their new posts after the 18th National Congress of the Communist Party of China. From the starting point of their careers, it took them an average of 38 years to be promoted to the current top leadership position.

　　It takes at least 23 years on average to get from low-level grassroots party member to ministerial-level cadres.

　　From more than 7 million cadres, the chance of becoming a ministerial-level cadre is only one in 14,000.

Since the beginning of this year, in the face of the downward pressure of the economy, all localities and departments have adhered to the principle of stability and progress, coordinated the prevention and control of epidemic situation and economic and social development, and taken various measures to do a good job in stabilizing growth, employment and prices. With the efforts of various policies and the gradual release of policy effects, the normal economic order will be quickly restored and the economic operation will soon return to the normal track.

A few days ago, the macro data of China’s economy was released in April. Affected by the new round of epidemic and the unexpected changes in the international situation, the new downward pressure on the economy has increased. How to treat the current economic situation?

At the online press conference of the National Development and Reform Commission in May, Meng Wei, a spokesperson, said: "At present, the domestic epidemic rebound has been effectively dealt with, and various policies have been put forward and the policy effects have been gradually released. I believe that the normal economic order will be quickly restored and the economic operation will soon return to normal track."

Steady growth-

Effectively coordinate epidemic prevention and control and economic and social development, and strive to stabilize the macroeconomic market.

Faced with the complexity, severity and uncertainty of China’s economic development environment, how to make steady growth work? What are the practical measures to stabilize employment? What are the advantages of stabilizing prices?

Adhere to the principle of stability, strive for progress in stability, and put steady growth in a more prominent position. Effectively coordinate epidemic prevention and control and economic and social development, and various measures are intensively introduced.

Steady investment, macro-policy is in the forefront. From January to April, the National Development and Reform Commission approved 38 fixed assets investment projects with a total investment of 533.3 billion yuan. Among them, 8 fixed assets investment projects were approved in April, with a total investment of 18.8 billion yuan, mainly in the fields of informationization and energy. At present, the quota of local government special bonds used for project construction in 2022 has all been issued. By the end of April, about 1.4 trillion yuan of special bonds have been issued this year.

Smooth circulation, ensure the accessibility of material transportation. In view of the problems in some areas, such as blocked cross-regional logistics and poor port transportation, all localities and departments have made a combination of boxing: eliminating card points, strengthening the monitoring of the traffic situation of expressways and ordinary national highways and the transportation of key materials, and promoting the implementation of a unified national pass system. As of May 16th, the decline of truck traffic in the Yangtze River Delta continued to narrow, and all toll stations and service areas in key epidemic-related areas were opened. Through blocking points, four production materials transfer stations were built in Shanghai, Ningbo and Hangzhou, which played an important role in promoting the resumption of production in key industries such as automobiles.

Reduce costs and effectively stimulate market vitality. While continuing to implement institutional tax reduction and fee reduction to support manufacturing, small and micro enterprises and individual industrial and commercial households, we will improve and optimize the policy arrangements for phased cost reduction and exempt small-scale taxpayers from value-added tax in stages; Give priority to small and micro enterprises’ tax refund, increase tax incentives for innovation of small and medium-sized science and technology enterprises, and guide more funds to flow to key areas and weak links … This year’s cost reduction "spree" combines phased measures with institutional arrangements, inclusive fairness with precise support, with practical measures and great efforts.

Prevent risks and strengthen industrial chain monitoring and early warning. The National Development and Reform Commission guides all localities to establish a risk monitoring and disposal system for the industrial chain supply chain, grasp the emerging risks in a timely manner, and coordinate and solve them in a targeted manner. Especially for key enterprises in integrated circuits and other fields, we should implement daily scheduling and strengthen cooperation to help coordinate and solve the problems faced by enterprises, such as limited return of personnel, poor transportation of raw materials, and suspension of production by suppliers, so as to drive upstream, downstream, large, medium and small supporting enterprises to resume work and production.

"We will thoroughly implement the decision-making and deployment of the CPC Central Committee, intensify macro-policy adjustment, fully expand domestic demand, make precise efforts to expand effective investment, promote the implementation of a number of major projects that are beneficial to both the present and the long term, stabilize market players, and promote enterprises to resume work and reach production as soon as possible under the conditions of epidemic prevention and control, effectively protect and improve people’s livelihood, and strive to stabilize the macroeconomic market." The spokesman said.

Stable employment-

The employment situation continued to be under pressure, and the work of stabilizing employment was implemented in four aspects.

Employment is the foundation of people’s livelihood. Since March, due to the influence of many domestic epidemic spots, wide coverage, frequent occurrence and the more complicated and severe international situation, the difficulties of market participants have increased significantly, and it has become more difficult for some key groups to find jobs, and the unemployment rate in urban surveys has increased. In April, the national urban survey unemployment rate was 6.1%, up 0.3 percentage points from the previous month, and the employment situation continued to be under pressure.

In view of the grim situation and challenges in the field of employment, recently, the CPC Central Committee and the State Council have made many arrangements to study the employment problem, and many departments have introduced relevant measures to do everything possible to stabilize existing employment and actively increase new employment. How to further strengthen the implementation of the employment priority policy? The spokesman said that the implementation of various measures to stabilize employment will focus on promoting four aspects of work.

Guarantee market players and employment. Under the condition of doing a good job in epidemic prevention and control, we will promote enterprises to return to work and reach production. We will speed up the implementation of policies to help enterprises get out of trouble, such as tax refund, tax reduction and fee reduction, and deferred payment of social security fees, make greater efforts to reduce costs, strengthen accurate support for manufacturing, contact service industries, small and medium-sized enterprises and individual industrial and commercial households, further reduce the burden on market players, and help them tide over difficulties and hold their posts.

Promote innovation and entrepreneurship to bring employment. Clean up and remove unreasonable restrictions on employment and entrepreneurship, further enhance the leading role and service capacity of the dual-innovation demonstration base, carry out in-depth demonstration actions of entrepreneurship to promote employment, and enhance the service capacity of the dual-innovation platform. We will strengthen the construction of platforms such as the Pioneer Park and encourage entrepreneurs to start businesses in their hometowns. Support multi-channel flexible employment, strengthen the protection of workers’ rights and interests in new employment forms, and continuously release the kinetic energy of innovation and entrepreneurship.

Grasp key groups and stabilize employment. We will implement the spirit of the Notice on Further Improving the Employment and Entrepreneurship of Young College Graduates and encourage local governments to introduce more support policies. We will further promote the construction of a demonstration park for the integration and development of rural industries, vigorously develop rural industries to enrich the people, actively promote the way of work instead of relief in the field of rural infrastructure construction, and expand local employment channels for farmers.

Talent training strengthens employment support. Deepen the integration of production and education in vocational education, school-enterprise cooperation, and continue to support the construction of pilot cities for improving the quality and quality of vocational education and integrating production and education. Increase support for the construction of public training bases, promote the combination of production and training with high quality, promote the co-construction and sharing of vocational skills training resources, and help carry out large-scale vocational skills training and training.

Stabilize prices-

The supply of industrial and agricultural products and services is abundant, and we will do our best to ensure the supply and price stability of bulk commodities.

Since the beginning of this year, international commodity prices have fluctuated at a high level, and all major economies in the world are facing greater inflationary pressures. In sharp contrast with other major economies, in April, China’s CPI rose by 2.1% year-on-year. Under the pressure of imported inflation, it is not easy for China’s prices to maintain a stable and moderate increase.

"In the face of the complicated and severe external situation, China has coordinated epidemic prevention and control and economic and social development, accurately grasped the rhythm of macroeconomic policies, and continued to do a good job in ensuring supply and price stability of important commodities." The spokesman said that all localities and departments have taken various measures to ensure supply and stabilize prices. Since the beginning of this year, China’s prices have been operating within the overall reasonable range. In April, the core CPI excluding food and energy prices declined steadily, rising by 0.9% year-on-year, and the growth rate dropped by 0.2 percentage points from last month.

Generally speaking, the market supply capacity of goods and services in China is relatively sufficient, and there are many favorable conditions for maintaining price stability.

Food prices are stable and have a foundation. Recently, international food prices have been rising, but the domestic situation has remained generally stable. China’s grain production has been stable at more than 1.3 trillion Jin for seven consecutive years, and its inventory is relatively sufficient. Fu Linghui, spokesman of the National Bureau of Statistics, said that the output of two kinds of rations in China has exceeded the demand for many years, and a small amount of imports are mainly variety adjustment. Corn and soybean have a certain import volume, which will be affected by the international market to a certain extent, but the impact is limited. Since the beginning of this year, China’s grain production situation has continued to improve, and there is a good foundation for maintaining stable grain prices.

The energy supply is stable and secure. China’s oil and natural gas exploitation ratio is relatively high, and the rising price of international energy products will increase the import cost to a certain extent, bring import influence to some industries, and increase the pressure of cost-driven price increase. However, it should be noted that China’s main energy source is coal, while China’s coal reserves are relatively rich and its production capacity is strong. With the gradual release of advanced coal production capacity, it is conducive to curbing the rise in energy prices. In April, China’s coal output increased by 10.7% year-on-year, and the price increase of coal mining and washing industry dropped by 0.5 percentage points year-on-year. The spokesman said that the National Development and Reform Commission will take coal as the "anchor" to do a good job in energy supply and price stabilization, and stabilize electricity prices by stabilizing coal prices, thus stabilizing the overall energy cost.

Most industrial consumer goods have sufficient supply capacity. China has a complete industrial system and strong supporting capacity, and the output of major industrial products is in the forefront of the world, laying a solid foundation for product price stability. The spokesman said that the joint supervision of the spot market will be strengthened with relevant departments, and illegal acts such as fabricating and spreading price increase information, hoarding and driving up prices will be severely cracked down, especially the malicious speculation of capital.

"We will adhere to comprehensive policies and precise regulation, and do our best to ensure the supply and price stability of bulk commodities." The spokesman said that in the later period, China has strong economic resilience, large market space, rich policy toolbox and abundant supply of industrial and agricultural products and services, and is fully qualified, capable and confident to continue to maintain stable price operation. (Reporter Lu Yanan)

Original Ruijin Infectious Diseases Department Ruijin Infectious Diseases Department

At the 4th Yangtze River Delta Liver Disease Summit Forum and Multidisciplinary Symposium on Diagnosis and Treatment of Liver Tumors in 2020, Professor Xie Qing, Director of Infectious Diseases Department of Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, gave a wonderful report entitled "Risk Assessment and Screening of ——HCC, an urgent problem in the management of chronic hepatitis B in the anti-virus era". The following is a written record.

Professor Xie Qing first introduced a typical clinical case of hepatocellular carcinoma (HCC) after regular follow-up of antiviral therapy for chronic hepatitis B (CHB):

The patient is female, who has been diagnosed with hepatitis B for more than ten years, and her mother and sister have hepatitis B (+), and her sister has a history of hepatitis B liver cancer, and has no other chronic diseases and personal bad hobbies; Liver biopsy was performed after the patient had mild abnormal liver function for the first time, and the result of liver puncture showed that inflammation was grade 3 and fibrosis was grade 2 (G3S2), so entecavir was given antiviral treatment. Patients were followed up regularly for 3-6 months. During the 5-year follow-up of antiviral therapy, low-echo nodules in the left lobe of liver were found by B-ultrasound, with a diameter of about 1.5cm, and AFP was normal. After enhanced MRI and multidisciplinary consultation of liver tumors, HCC was diagnosed and surgically removed. Postoperative pathology showed that hepatocellular carcinoma was grade II-III, with a size of 1.5×1.3×0.6cm, MVI=0, and the surrounding liver tissue showed micronodular cirrhosis, G4S4.

It can be seen from the above cases that after receiving antiviral treatment, patients with early cirrhosis can not completely avoid the risk of HCC even if they maintain high compliance and follow-up regularly to achieve sustained virological and biochemical response.

This brings severe challenges to the management of CHB patients: in the era of antiviral therapy, how should we accurately assess the risk of HCC and standardize HCC screening?

The incidence and mortality of HCC in China are high, ranking the top five in the list of high-incidence malignant tumors in China all the year round, and hepatitis B is the main cause of HCC in China. At present, the prevention and treatment of HCC mainly reduces the global disease burden of hepatitis B HCC through three-level prevention strategies, and combined with hepatitis B cure can further eliminate HCC. At the level of primary prevention, the introduction and implementation of the "small shell" project in China has made 100% of CHB pregnant women with high viral load blocked from mother to child; At the level of secondary prevention, through the management of HBV-infected people without HCC, they can receive antiviral treatment as soon as possible, and optimize the existing antiviral scheme to make more hepatitis B patients cure; At the level of tertiary prevention, the remaining liver function can be improved and the risk of HCC recurrence can be minimized by allowing the radical HCC population to continue antiviral treatment.

A large number of clinical studies have shown that long-term oral administration of NAs antiviral drugs can reduce the risk of HCC, but it cannot completely prevent HCC. The following are data from Japanese and Hong Kong, China population cohorts.

Japanese data:

Hong Kong, China data:

A clinical study from 24 countries shows that obtaining virological response can reduce the progression of liver-related diseases and the incidence of HCC, but there is still a risk of HCC. The research results were published in Clin Gastroenterol Hepatol this year (if = 8.549), and the team of Ruijin Hospital provided nearly 150 cases with a 10-year follow-up cohort.

A 10-year cohort study of Jia Jidong’s team in China showed that the effective inhibition of virus by NAs can significantly reduce the occurrence of HCC, but there is still a high risk of HCC in patients with existing liver cirrhosis, and the cumulative incidence of HCC can be as high as 43.16%.

A nationwide historical cohort study in Korea also aims to explore the risk of HCC in CHB patients receiving antiviral therapy. A total of 24,156 adult CHB patients with newly diagnosed NA were included in the study, and they were treated with ETV (n = 11,464) or TDF (n = 12,692), among which 26.1% and 27.5% were cirrhosis patients in ETV group and TDF group respectively. At the same time, the hospital cohort was used for external verification, including 1560 newly diagnosed adult CHB patients treated with ETV and 1141 patients treated with TDF. The results are as follows.

Xie Qing’s team’s evidence proves that antiviral therapy can reduce the occurrence of HCC, but there is still the risk of HCC after NAs treatment, and PegIFN treatment of CHB is better than NAs (especially for high-risk people) in reducing the risk of HCC. This retrospective study used the published HCC risk scoring system to score each patient, with an average follow-up time of 5.41 years.

Combined with the above clinical research ideas, Ruijin Hospital team has carried out the first prospective intervention study based on high-risk population of HCC in China, which was randomly divided into NAs treatment group and IFN+NAs combination treatment group. The primary/secondary endpoints and research outline are briefly described as follows.

A large number of research data show that antiviral therapy can not completely prevent HCC, so the risk assessment of HCC during HBV infection has become an important proposition. The existing HCC risk prediction models include the evaluation model for patients who have not received antiviral treatment, represented by REACH-B score (Taiwan, China), GAG-HCC score (Hong Kong, China) and CU-HCC score (Hong Kong, China), and the evaluation model for patients who have received antiviral treatment, represented by mREACH-B score (Korea).

CAMD scoring adds diabetes as the basic disease to the traditional scoring rules, which optimizes the application of HCC risk prediction model in high-risk patients.

The latest aMAP score is combined with the patient’s age, sex, bilirubin, albumin, platelet and other indicators to optimize the operation model. The aMAP score of 0-50 is defined as a low-risk group of HCC, and the cumulative incidence of HCC in 5 years is 0.8%. Correspondingly, the score of 50-60 is defined as a medium-risk group, and the cumulative incidence of HCC in 5 years is 4.2%, while the score of 60-100 is defined as a high-risk group.

At present, the HCC screening policies recommended by major international guidelines in the field of hepatology are not the same. Here, Professor Xie Qing makes a clear comb for the participants.

Finally, Professor Xie Qing summarized the diagnosis route of HCC and the crowd management process of different risks of HCC in CHB, based on the major clinical research results, guidelines recommendation and clinical experience at home and abroad, so as to provide reference for clinicians to further guide clinical practice.

Read the original text

Hangzhou Municipal Bureau of Commodity Price Hangzhou Health and Family Planning Commission
Notice on Issuing the Opinions on Strengthening the Management of Medicine Price in Non-public Medical Institutions in Hangzhou

Hangjiafu [2014] No.161

District, county (city) Price Bureau, Health Bureau and non-public medical institutions:
　　In order to strengthen the medical price management of non-public medical institutions, standardize the medical price behavior, safeguard the legitimate rights and interests of patients and non-public medical institutions, and further promote the healthy development of non-public medical institutions, According to the National Development and Reform Commission, the National Health and Family Planning Commission, Ministry of Human Resources and Social Security’s Notice on Issues Related to the Implementation of Market-regulated Prices for Medical Services in Non-public Medical Institutions (No.503 [2014] of the Development and Reform Commission), Opinions of the People’s Government of Zhejiang Province on Promoting the Accelerated Development of Private Medical Institutions (No.46 [2013] of Zhejiang Province), The Zhejiang Provincial Price Bureau’s Notice on Standardizing the Clear Price of the Medical Industry in the Province (Zhejiang Price Inspection [2001] No.463) and other documents, combined with the actual situation of our city, formulated the Opinions on Strengthening the Management of Pharmaceutical Prices in Non-public Medical Institutions in Hangzhou, which has been legally reviewed and agreed by the municipal government, and are hereby printed and distributed to you, please follow them.

Hangzhou bureau of commodity price
Hangzhou Health and Family Planning Commission
September 9, 2014

　　CCTV News:On October 20th, the State Council held a press conference on the development of industry and informatization in the first three quarters of 2023. Zhao Zhiguo, spokesperson and chief engineer of the Ministry of Industry and Information Technology, introduced the development of industry and information technology in the first three quarters.

　　Zhao Zhiguo said that in the first three quarters, the development of industry and informatization was generally stable, the industrial structure was continuously optimized, new kinetic energy and new advantages were continuously gathered and enhanced, the vitality of innovation and development was continuously released, and high-quality development achieved positive results.

　　First, the industrial economy has recovered. We have implemented a series of steady growth policies "combination boxing" issued by the State Council, and constantly stabilized the industrial economy to resume its development momentum. From the main economic indicators, it has the following characteristics: industrial production has grown steadily. In the first three quarters, the added value of industrial enterprises above designated size increased by 4% year-on-year, and the growth rate was 0.2 percentage points faster than that in the first half of this year. The proportion of added value of manufacturing industry in GDP has remained basically stable, and investment in manufacturing industry has continued to grow, and the growth rate has gradually accelerated since July. The efficiency of enterprises has been accelerated. Among them, in August, the profits of industrial enterprises above designated size increased by 17.2% year-on-year, and the operating income and profits all turned from negative to positive.

　　Second, the high-quality development of the manufacturing industry has taken solid steps. We vigorously promoted the accelerated development of advanced manufacturing industries. In the first three quarters, investment in high-tech manufacturing industries increased by 11.3% year-on-year, which was 5.1 percentage points higher than investment in manufacturing industries. Accelerate the cultivation of new products, new industries and new formats, achieve rapid growth in new energy vehicles, photovoltaic products, aerospace vehicles and equipment, and continue to lead the shipbuilding industry in the world. Accelerate the process of digital transformation, promote the scale expansion and level improvement of smart factory construction, and have built nearly 10,000 digital workshops and smart factories. Create new scenarios, new solutions and new models for intelligent manufacturing, and achieve remarkable results in industrial quality improvement and efficiency improvement.

　　Third, the information and communication industry has maintained steady growth. We continue to give play to and consolidate the advantages of the information and communication industry and support high-quality economic and social development. In the first three quarters, the telecom business revenue increased by 6.8% year-on-year, and the total business volume increased by 16.5% year-on-year. The network infrastructure has been continuously consolidated. By the end of September, 3.189 million 5G base stations had been built, with 145 million gigabit broadband users. The network service capacity has been continuously upgraded, with the total computing power reaching 197 trillion floating-point operations per second, and the mobile network IPv6 traffic accounts for 58.4%. Innovative and integrated applications have been comprehensively deepened. 5G applications have been integrated into 67 categories of national economy. There are more than 7,000 "5G+ Industrial Internet" projects nationwide, and the number of mobile Internet of Things terminals has reached 2.22 billion. The people’s livelihood of Pratt & Whitney has been steadily improved, and 1924 commonly used websites and apps, over 140 million smart phones and smart TVs have been promoted to complete the aging transformation.

　　Fourth, the development of small and medium-sized enterprises has achieved remarkable results. We strengthened policy support and implemented some measures to help small and medium-sized enterprises to stabilize their growth and adjust their structural strength. In the first three quarters, many key indicators of the economic operation of small and medium-sized enterprises rebounded. Strengthen service support, and carry out the SME service action and SME service month. Strengthen digital transformation, select and publicize the first batch of 30 pilot cities for digital transformation of small and medium-sized enterprises, and promote the deep integration of digital economy and real economy. Strengthen the cultivation of high-quality enterprises, and cultivate a total of 103,000 specialized and innovative small and medium-sized enterprises, 12,000 specialized and innovative "little giant" enterprises, and 200 characteristic industrial clusters of small and medium-sized enterprises, playing an important role in strengthening the chain.

　　Generally speaking, although the current industrial economy is facing difficulties such as insufficient demand, the long-term positive fundamentals of China’s industrial economy are still stable. In particular, the successful convening of the National New Industrialization Promotion Conference has injected a strong impetus into the development of the industrial economy, and we are fully confident that the industrial economy will further pick up and improve.

Poster of Camouflaged Couple

The autumn Japanese TV series "Camouflaged Couples" starring Yuuki Amami and Itsuki Sawamura finally aired the tenth sentence last week and ushered in the grand finale of the whole drama. In the end, the words got a good rating of 12.8%, and the ratings of the whole drama did not fall below 10%, which once again proved the fact that even though the workload was reduced due to physical reasons, the high popularity of Queen Tianhai in the neon country could not be shaken.

Two online celebrity dramas, Camouflaged Couples, which are juxtaposed with Five to Nine, offer a stunt of "form marriage" to meet the topic of "marrying a monk" on September 9. Yuuki Amami plays Jia Menxun, a 45-year-old librarian who is still alive. Although she always smiles on the surface, she has the attribute of a barrage inside.

Whether it’s family, colleagues or complete strangers, they will be mercilessly whipped by the Queen. Jiamen, who has been studying alone for a lifetime and then died silently, met her ex-boyfriend Yangcun Chaozhi who took her virginity in college and left mercilessly one day. With a smile on his face, Chaozhi kept befriending Jiamen like no one else. Finally, he brazenly proposed marriage. It’s just that this engagement is a scam in every sense. First of all, he did this to comfort his mother who claimed to be terminally ill and was about to die. More importantly, Chaozhi has become an out-and-out gay man and doesn’t love women at all!

Stills of Camouflaged Couple, Itsuki Sawamura and Asuka Kudoh.

The story unfolds slowly on the premise of such a god. After a series of processes, in which the man acted as the master and slave until it seemed to be really straight, and the woman acted as the master and slave until the corner and then returned to straight, Jiamen and Chaozhi finally found that they cared about each other the most, so after they got married and divorced, they solemnly filled in their names on the marriage registration form again.

Stills of "Camouflaged Couple",Itsuki Sawamura and Yuuki Amami.

But in my opinion, The Camouflaged Couple is not 100% unfinished. First of all, Kazuhiko Yukawa, the screenwriter, said in an interview with Japanese media before the broadcast that there was no attempt to discuss "gender issues" in depth. His original intention was to show the other side of his muse Yuuki Amami, who was deeply resentful under his gentle appearance. Whether it is the excavation of the heroine Jiamen’s childhood experience and family relationship, or the climax setting of each episode, it has realized the good intention of Youchuan screenwriter to create scripts for Queen Tianhai.

On the other hand, I also think that behind the seemingly far-fetched turning point, "Camouflaged Couples" still carried out the discussion about marriage to the end.

Under this premise, we urgently need film and television works that can seriously discuss the relationship between men and women and the true meaning of marriage. The completion of "Camouflaged Couples" in this respect is undoubtedly very high. Through the constant changes of the protagonists, the play first reveals the fact that gender roles are largely mobile. In the past two years, it seems that the momentum of both English dramas and American dramas is only "politically correct" to encourage everyone to be brave and "turn from straight to curved". But equally important, everyone may think from a bend or become straight, which is ignored by us intentionally or unintentionally. The final ending of The Camouflaged Couple undoubtedly reminds us of such a possibility.

Stills of "Camouflaged Couple"

Then again, the lack of positive expression of minorities in film and television dramas is indeed a problem that Japan has to look directly at. As a developed country with no religious burden, Japan first passed the so-called "same-sex partner regulations" in Shibuya District at the beginning of this year, which basically has no legal effect. As revealed in "Camouflaged Couples", even in Japan today, there are still citizens who are discriminated against in the workplace because of their sexual orientation. The pink signboard of "Five to Nine", which will be removed soon, still overlooks Shibuya, the most crowded intersection in the world. In Japan, monks can get married long ago, but there is still no legislation on same-sex marriage.

　　　　　　 CCTV News:On the 25th, the National Security Agency of Ukraine announced that it had detained a Russian oil tanker in the port of Izmir in southern Ukraine in cooperation with the Ukrainian military procuratorate. Later on the 25th, 10 crew members of the detained Russian oil tanker were released and flew to Moscow in the early morning of the 26th, but the oil tanker was still detained by Uzbekistan. The Russian side said that this move is a provocative act of Ukraine.　

　　　　　　 Sputnik news agency & radio No.26 quoted Sergei Carpau, the chief engineer of the Russian oil tanker, as saying that the staff of the Ukrainian National Security Agency spoke Russian when they detained the Russian oil tanker in Izmir Port, but only asked some questions and did not beat or scold the crew.

　　　　　　 The Ukrainian National Security Agency said that the detained Russian oil tanker participated in intercepting Ukrainian naval vessels in the Kerch Strait on November 25 last year, and assisted the Russian border guards in detaining Ukrainian vessels and 24 crew members. Uzbekistan said that it hopes to find relevant evidence of the "conflict in the Ukrainian Kerch Strait". However, in their investigation, they did not find that the Russian crew had ever participated in illegal activities, so they have allowed the crew to return to Russia. However, the Russian oil tanker is still being detained in Izmir Port.

　　　　　　 In response to the incident of the Russian oil tanker being detained, Russian Deputy Foreign Minister Carracin said on the 25th that Russia believed that some people in Ukraine wanted to continue the provocative actions taken against Russia in the Kerch Strait last year. The Russian side will investigate the matter in detail. Colin Cevic, a member of the National Defense and Security Committee of the Russian Federation Council, also said that the release of the detained Russian crew members does not mean that the matter is over, and Russia demands that the oil tanker be returned immediately.

　　　　　　 On November 25 last year, Russia and Ukraine clashed in the Kerch Strait. Russian border guards detained three Ukrainian naval vessels and Ukrainian military personnel on board. Both sides have their own words on this incident. Since then, Ukraine has declared that 10 regions adjacent to Russia have entered a "state of war". Tensions between Russia and Ukraine are escalating.

　　　　　　 Ten crew members of the Russian oil tanker detained by Ukraine arrived in Moscow on the early morning of 26th, but the oil tanker was still detained by Ukraine. Although there are still many details about the arrest, the timing is very delicate. Because Ukrainian President Zelensky recently telephoned Russian President Vladimir Putin to discuss the release of Ukrainian detainees in the Kerch Strait incident and proposed to meet with Putin to discuss the conflict in eastern Ukraine, Putin also said that he would not refuse any form of talks. Some analysts pointed out that the arrest of the ship occurred when Russia and Ukraine may start negotiations on eastern Ukraine, which not only reflected the political game in Ukraine, but also cast a shadow over the negotiations between Russia and Ukraine and the relaxation of bilateral relations.

　　　　　　 Some analysts believe that Russia’s response to the incident of the oil tanker being detained this time is cautious and restrained, and it is not hoped that this incident will undermine the prospect of the meeting between the Russian and Ukrainian heads of state. At present, the diplomatic settlement process of the eastern Ukraine issue is deadlocked, and both Russia and Ukraine hope to make a difference.

　　　　　　 From Russia’s point of view, Putin needs to show the West his positive attitude in solving the problem of eastern Ukraine, so as to urge the West to reduce or even lift sanctions against Russia. In addition, the economic development and people’s life in eastern Ukraine are facing difficulties, which requires a large number of blood transfusions from Russia, causing a huge burden on Russia. Therefore, Russia hopes to persuade Ukraine to lift the blockade through negotiations.

　　　　　　 From Uzbekistan’s point of view, Zelensky needs to fulfill its promise to achieve peace in the eastern region through diplomatic means during the election campaign.

　　　　　　 Analysts believe that the issue of eastern Ukraine involves Ukraine’s core interests, and there is a geopolitical game between Russia and the West behind it, and its diplomatic settlement process still faces many challenges. Even if Zelensky and Putin can meet, they are unlikely to reach an agreement on major issues such as the autonomous status of eastern Ukraine, and they can only make concessions on some minor technical issues. However, affected by the eastern Ukraine issue, it is difficult for Russia-Ukraine relations to improve substantially.

　　CCTV News:The Central Meteorological Observatory continued to issue a red rainstorm warning at 10: 00 on July 30. Since July 29, there have been heavy rainstorms in central and southern Hebei, central and southern Beijing, Tianjin, eastern Shanxi, central and northern Henan, and central and western Shandong, heavy rainstorms in parts of central and southern Hebei, northern Henan, eastern Shanxi, and western Shandong, and heavy rainstorms (250-540 mm) in parts of central and southern Hebei, along mountains in central and southern Hebei, and northwest Henan.

　　It is estimated that there will be heavy rainstorms in most parts of Hebei, Beijing, Tianjin, central and eastern Shanxi, northern Henan and western Shandong from 14: 00 on July 30 to 14: 00 on July 31, among which there will be heavy rainstorms in parts of eastern Shanxi, central and southern Hebei and most parts of Beijing, and heavy rainstorms (250-350 mm) in parts of central Hebei and western Beijing. There are heavy rains or rainstorms in central Anhui, eastern Hubei, northwestern Hunan, eastern Fujian, northern and southern Guangxi, southwestern Yunnan, southern Sichuan, southeastern Heilongjiang, northern Jilin and northeastern Xinjiang. Some of the above areas have short-term heavy rainfall (the maximum hourly rainfall is 20 ~ 40 mm, and the local area can exceed 60 mm), and there are strong convective weather such as thunderstorms and strong winds.

　　Defense guide:

　　1, the government and relevant departments in accordance with their duties to do a good job in emergency and rescue work against heavy rain;

　　2. Stop the assembly, suspend classes or business (except for special industries);

　　3, do a good job in mountain torrents, landslides, mudslides and other disasters prevention and rescue work.

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2021 is Cells The tenth anniversary of the publication of periodicals. As of now,Cells　The journal has published more than 9,300 papers, and its homepage has been visited by more than 50,000 people every month. We support you.　Cells　The authors, readers, peer reviewers, editors and others who have contributed to the journal express their sincere thanks.

To celebrate this important moment, the journal created a series of commemorative special issues "10th Anniversary of Cells— Advances in Cell Microenvironment ",this special issue invited Professor Alexander Dityatev, Professor Mark R. Wilson and Professor Dmitri Rusakov, experts in the field of cell microenvironment, as guest editors. Related research topics focused on include, but are not limited to: ECM remodeling, mechanical transduction, stem cell niche, tumor microenvironment, neural network and synaptic microenvironment, reconstruction and repair of cell microenvironment with injectable ECM scaffold, gene therapy and pharmacological targeting, experimental modeling of microenvironment using micro-mode and micro-fluid, and system biology of cell microenvironment. We sincerely welcome all scholars and researchers in this field to contribute enthusiastically.

Deadline for submission of special issue: September 15th, 2022.

Guest editor

Prof. Dr. Alexander Dityatev

German Centre for Neurodegenerative Diseases (DZNE)

Prof. Dr. Alexander Dityatev is a professor at the German Center for Neurodegenerative Diseases (DZNE) and the head of the molecular neuroplasticity group. He received his doctorate from the Institute of Evolutionary Physiology and Biochemistry in St. Petersburg, Russia. His research group mainly studies extracellular matrix (ECM), and its potential mechanism involves many mechanisms, including L-type voltage-gated Ca2+ channels, NMDA receptors, Ca2+-dependent K+ channels and the regulation of axonal excitability, focusing on the mechanism of controlling ECM up-regulation and downstream events affecting synaptic and cognitive functions. So far, his article has been cited 8570 times.

Prof. Dr. Mark R. Wilson

University of Wollongong, Australia

Prof. Dr. Mark R. Wilson is a senior professor of chemistry and molecular biology at the University of Wollongong, Australia. He took the lead in identifying and studying extracellular (secretory) mammalian chaperones and their roles in protein’s homeostasis (protein homeostasis). He also conducted basic research on protein homeostasis mechanism of supporting diseases, such as motor neuron diseases. His research team has accumulated expertise in a wide range of technical fields, including confocal microscopy, flow cytometry and the production of recombinant proteins that require a lot of post-translational modifications (such as extracellular chaperones). So far, his article has been cited 6562 times.

Prof. Dr. Dmitri Rusakov

university college london

Prof. Dr. Dmitri Rusakov is a professor at University College London and a member of the synaptic imaging team. He mainly studies the formation and integration of signals in neural circuits of astrocytes, the organizing principles of synaptic structure and function, the activity-dependent control of neurotransmitter release, and the nano-molar landscape of basic Ca2+ in neurons and astrocytes. Its research is helpful for interdisciplinary efforts to solve the cellular mechanism of epilepsy and other neurodegenerative diseases. Up to now, his articles have been cited 8141 times.

Special issue details page:

https://www.mdpi.com/journal/cells/special_issues/Anniversary_Cell_Microenvironment

CellsPeriodical introduction

Editor in chief:

Cord Brakebusch, The University of Copenhagen, Denmark

Alexander E. Kalyuzhny, Neuroscience, USA

It mainly publishes research in cell biology, molecular biology and biophysics. At present, it has been included in databases such as SCIE (Web of Science), PubMed, MEDLINE and PMC.

2020 Impact Factor: 6.600

2020 CiteScore: 6.663

Time to First Decision: 16 Days

Time to Publication: 39 Days