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For the post-85 s or post-90 s families in the career rising period, a large-space comfortable SUV is not only an upgrade of transportation, but also a reconstruction of family lifestyle-it needs to carry the laughter and laughter of camping on weekends, be competent for the comfortable demand of long-distance self-driving, and act as a mobile fortress for the whole family in daily commuting. When the market is caught in an involution of "parameter stacking",(positioningFamily Big Six Wisdom Flagship SUVStarting from the "real scene of family users", we "practice" ourselves in three dimensions: space design, comfortable experience and intelligent safety, which brings different choices to consumers.

The picture is as follows:Section 2025 Rear drive Ultra+

The following will be in 2025. Take the rear-drive Ultra+ as an example to see how the Deep Blue S09 performs.At the same time, let’s see what kind of performance can be achieved in the comparison between Deep Blue S09 and the same-class models (Wenjie M9 and Ideal L9)!

At present, the 2025 Deep Blue S09 offers five models, namely:Rear-drive Max, rear-drive Ultra, four-wheel drive Ultra, rear-drive Ultra+ and four-wheel drive Ultra+ are high-end versions, and the price is 239,900-309,900 yuan.

In the design part, Deep Blue S09 continues the latest family design scheme of Deep Blue Automobile, in which the front face adopts semi-closed design, and it is also equipped with split star ring petal penetrating headlight group (penetrating LED dynamic light strip above and adaptive full LED far and near light source system below). In addition, a trapezoidal blackened air inlet is added to the bottom of the front enclosure to enhance the visual layering and dynamic atmosphere of the front face.

Coming to the side of the car body, the slender body lines and tall body contours of the dark blue S09 make the whole car create a good sense of gas field. At the same time, a large number of curved surface designs are used in the car body, which further enhances the layering and strength of the vehicle with the ridge lines raised under the door and at the front and rear wheel arches.

In addition, Deep Blue 09 also provides electric adjustable exterior rearview mirror, electric hidden door handle, front and rear double-layer sound insulation glass, rear privacy glass and other configurations.

The body dimensions of Deep Blue S09 are as follows:5205x1996x1800mm, with a wheelbase of 3105mm, positioning a new energy large SUV.

In terms of wheels, the rear-drive version and the four-wheel drive Ultra models are equipped with 20-inch streaming wheels (255/50 R20), the four-wheel drive Ultra+ high-definition version is equipped with a 21-inch dome multi-spoke wheel hub+265/45 R21 Michelin PS4 SUV tire.

In terms of paint color, the rear-drive Max version only provides "Smoke Blue" paint color; The remaining models (Ultra version) are available in four paint colors (Xuan Mo Black, Shan Xue Yin, Cangshan Grey and Yanbo Blue).

In the rear part, the deep blue S09 uses a penetrating Milky Way petal neon taillight group+a luminous rear logo, and a spoiler+a high-position brake light is also equipped above the rear windshield. At the same time, a large area of blackened decoration+diffuser device is added to the bottom of the rear enclosure to enhance the vitality and dynamic properties of the rear.

In addition, Deep Blue S09 is also equipped with Huawei Gankun Intelligent Driving ADS (Huawei Gankun drives ADS SE and Huawei Gankun drives ADS Max.), the specific functions are as follows:

• Huawei gan Kun zhi Jia ADS SE (Max/ rear drive/Ultra rear drive/Ultra four-wheel drive）：The car body is integrated with 10 high-definition cameras +3 millimeter-wave radars +12 ultrasonic radars, enabling the vehicle to support 19 active safety early warning AIDS; Parking assistance (intelligent parking, remote parking, custom parking space, parking, parking service, etc.); Auxiliary driving functions such as pilot assistance (LCC urban area/altitude cruise assistance, NCA high-speed intelligent driving pilot assistance).
• Huawei Gankun Zhijia ADS Max (Rear-drive Ultra+/ Four-drive Ultra+ High Edition）：The body is integrated with a Huawei 192 beam lidar +11 high-definition cameras +3 millimeter-wave radars +12 ultrasonic radars, which is added on the basis of Huawei’s driving ADS SE.Huawei omni-directional anti-collision CAS 3.0 (including automatic acceleration of vehicles when the rear vehicle is chasing at high speed, and automatic braking of vehicles encountering obstacles when reversing); Follow the car/park on behalf of the driver; End-to-end pilot-assisted driving functions such as intelligent driving pilot assistance/parking-to-parking pilot assistance in NCA city.

In addition, Deep Blue S09 is equipped with Huawei Gankun Intelligent Driving ADS Max (current version is 3.3), and will upgrade Huawei Gankun Intelligent Driving ADS 4 in the second half of 2025.

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Intelligent assisted driving system is an important index to measure the scientific and technological content of modern automobiles, which is related to the safety and convenience of driving. It is a great "gospel" for busy families born after 1985/1990, and can reduce the burden in daily travel and long-distance driving.

Comparing the same class models (M9 and L9):

• Ask M9:It is equipped with the same Huawei Gankun Zhijia ADSMAX (version 3.3) as Deep Blue S09, which is inCore competence of intelligent driving systemAt the same level as Deep Blue S09.
• Ideal L9:provideIdeal AD Pro (visual intelligent driving scheme) and ideal AD Max (laser radar+visual intelligent driving scheme) two sets of auxiliary driving systems,The overall assisted driving ability is relatively reliable, but there is still room for growth in the coverage of intelligent driving functions.

From the comparison of intelligent driving systems, Deep Blue S09 and Wenjie M9, with Huawei’s technical support, have performed well in functional richness and scene adaptability, and the ideal L9 still has room for improvement. However, all three cars provide high safety and convenience for family travel.

In the interior design part, the deep blue S09 center console area is equipped with a three-position flat-bottomed steering wheel (four-wheel drive Ultra+ high-fixed version supports electric adjustment/memory/heating of the steering wheel), a 43-inch adaptive smart HD AR-HUD, and a dual 15.6-inch central control screen [(15.6-inch central control screen +15.6-inch passenger entertainment screen), while the rear-drive Max does not provide a 15.6-inch passenger entertainment screen].

At the same time, Deep Blue S09 also uses electronic gear shifting mechanism, and also provides three interior colors (shale gray, turquoise rice, dawn orange).

Integrated intelligent mobile island (can move 700 mm to the back)

10-liter cold and warm refrigerator (adjustable from minus 6 to above 50)

Front row 50W mobile phone wireless charging panel

Sectional non-openable panoramic skylight (with electric sunshade)

In terms of configuration, Deep Blue S09 provides wireless charging of 50W mobile phone in the front row, built-in driving recorder, 256-color ambient light, automatic anti-glare of interior rearview mirror, rain-sensing wiper, three-zone automatic air conditioning, segmented panoramic sunroof (with electric sunshade) and other configurations, and it is also optional.Integrated intelligent mobile island +10-liter cold and warm refrigerator further enhances the convenience of passengers in the car.

The lathe part, Deep Blue S09 is equipped with.HarmonySpace 5 in HarmonyOS cockpit supports full scene interconnection (intelligent ecosystem of people and cars), in-vehicle application mall, online audio and video, 6-tone voice recognition system, children’s exclusive AI elf, space Rubik’s Cube (big bed mode/flagship four-seat/space customization), situational mode (nap mode/camping mode/cinema mode), mobile phone remote car control, gesture recognition, OTA upgrade of the whole vehicle, in-vehicle 5G network and other functions.

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Car system is the "smart brain" in the car, which not only provides entertainment functions, but also affects the user’s operating experience and information acquisition. For the post-85 s/post-90 s families who pay attention to quality and sense of technology, a good car system is very important.

Comparing the same class models (M9 and L9):

• Ask M9:Using the same HarmonyOS cockpit as Deep Blue S09, it has a good performance in function and ecology.
• Ideal L9:Equipped with ideal smart space+Qualcomm Snapdragon 9295 chip,The multi-screen interactive experience in the family scene is good. However, compared with HarmonyOS cockpit, there is still room for improvement in the openness and ecological richness of the system.

On the whole, the HarmonyOS cockpit of Deep Blue S09 and Wenjie M9 performed well in system ecology and functional diversity, while the ideal intelligent space of the ideal L9 has its own characteristics in multi-screen interaction of family scenes, and users can choose according to their own emphasis on car functions.

In the seat part, the Deep Blue S09 adopts the layout of six "Yunqi seats", and the seats are wrapped in imitation leather or Nappa leather.

In terms of seat functionality, Deep Blue S09 comes standard with one/two/three rows of seats with electric adjustment, front seat memory and three rows of seats.50:50 ratio down. At the same time, the Ultra version also provides front seat heating/ventilation/massage/waist adjustment, two rows of seat heating/ventilation/memory/massage/waist adjustment/leg rest, and three rows of seat heating (three rows360mm ride height, three rows of 870mm leg space.) and other functions.

Two rows of double zero gravity seats

Two rows of folding tables

Two rows of 21.4-inch ceiling folding entertainment screens

20-channel loudspeaker

In addition, the Ultra version is equipped with two rows of double zero-gravity seats (supporting 180mm horizontal sliding and 121-degree one-button reclining), two rows of folding tables, two rows of 21.4-inch ceiling folding entertainment screens (3K resolution, 0 -79-degree angle adjustment) and a 20-channel sound system (7.3.4 panoramic sound, power of 2,232 watts), which further improves the passengers in the back row.

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For family cars, the spacious and comfortable space is the key, especially for six-seat SUVs. To meet the travel needs of the whole family, every seat cannot be "wronged".

Comparing the same class models (M9 and L9):

• Ask M9:The length, width and height of the boundary M9 are 5230*1999*1800mm, wheelbase 3110mm, the overall performance of the car’s sitting space and comfort is good (three rows of sitting height 330mm, three rows of leg space 853mm), but there is still room for improvement in the convenience of car activities.
• Ideal L9:The ideal L9 body size is 5218*1998*It is 1800mm and the wheelbase is 3105 mm. There is no problem in the overall interior space, but the riding experience of three rows of passengers needs to be improved (the height of three rows of seats is 298mm, and the legroom of three rows is 786mm). However, the overall interior design and seat material of the ideal L9 can provide good comfort.

From the comparison of ride space, Deep Blue S09/ Wonderland M9/ Ideal L9 has a good performance in terms of space flexibility, practicality, second/third row of ride space, etc., which can meet the needs of family travel, and can easily cope with daily commuting, long-distance travel, outdoor camping and other scenes.

In terms of storage space, the conventional storage capacity of the dark blue S09 trunk is 427 liters (seven 20-inch trunks can be placed), and one 20-inch trunk can be accommodated under the trunk cover. At the same time, when the third row of seats is put down, the storage volume of the trunk is increased to 1392 liters, which provides convenience for the placement of outdoor camping items or temporary rest during the trip.

[The conventional volume of the M9 six-seat trunk is 316 liters, and the third row of seats is raised to 1252 liters after being put down; The conventional storage capacity of the ideal L9 trunk is 332 liters, and it is raised to 1191 liters after the third row of seats are laid down.]

In addition, the deep blue S09 car seats also support a variety of layout modes: single bed (one/two rows of single-row seats), double bed (one/two rows of double-row seats), children’s bed (the third row of seats is laid down and the trunk is made into a bed), 1.9m rear cabin queen bed and 2.5m camping bed.

As for the power unit, Deep Blue S09 is equipped with the intelligent range extension system of the Force (1.5T range extension hybrid, the maximum power of 1.5T range extender is 110kW), and it provides two driving systems, namely, rear single motor and front and rear double motors. The detailed power parameters and energy consumption are as follows:

• Rear single motor:The maximum power is 231kW(314Ps), the maximum torque is 375N·m, the acceleration is 7.9 seconds, and the maximum speed is 205 km/h; The comprehensive fuel consumption of WLTC is 0.83L/100km, and the fuel consumption of WLTC feed is 6.6L/100km.
• Front and rear double motors: the comprehensive power of the system is 363kW(492Ps), the comprehensive torque is 637N·m, the acceleration at zero speed is 5.9 seconds, and the maximum speed is 205 km/h; The comprehensive fuel consumption of WLTC is 0.91L/100km, and the fuel consumption of WLTC feed is 6.9L/100km.

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In terms of battery life, Deep Blue S09 matches the 40.18kWh provided by Contemporary Amperex Technology Co., Limited.Ferrous lithium phosphate golden bell battery pack (supporting 3C charging rate), in which the pure electric cruising range of WLTC with two-wheel drive version is 180km (two-wheel drive version)/170km (four-wheel drive version), and the comprehensive cruising range of WLTC is 972km (two-wheel drive version)/927km (four-wheel drive version).

In terms of charging efficiency, Deep Blue S09 supports DC fast charging and AC slow charging, in which the battery can be charged from 30% to 80% within 15 minutes in DC fast charging mode.

In the chassis part, Deep Blue S09 is equipped with front double wishbone independent suspension and rear H-arm multi-link independent suspension. At the same time, Deep Blue S09 also comes standard.R-EPS variable speed electric power steering system, comfort braking CTS 2.0, DTDS/EDTC torque adaptation, curve traction system VDC 2.0 and other software and hardware systems.

In addition, the Ultra version also provides a magic carpet intelligent suspension system (withPavement preview technology, the recognition accuracy is more than 95%), covering CDC continuous variable damping shock absorber+single cavity air suspension (70mm height adjustment), further improving the driving stability of the vehicle and the comfort of passengers in the vehicle.

In terms of passive safety, Deep Blue S09 adopts "Thirteen horizontal and five vertical diamond bodies "design scheme, in whichThe passenger compartment is all made of high-strength steel, and the length of the front collision beam is 1636 mm (81% vehicle width coverage); Cooperate with the standard main and passenger airbags, one or two rows of side airbags, and three rows of 2700 mm integrated side air curtains in the front, middle and rear, and do your best to ensure the safety of passengers in the car.

When the automobile industry entered the era of "customer value regression", the appearance of Deep Blue S09 brought a new trend to the six-seat SUV market: the real high-end is not the number on the configuration table, but a deep understanding of family needs; True wisdom is not cold technology, but making technology serve the temperature of life. For young families born after 1985 or 1990, a good traveling family "partner" never lets any family compromise on comfort and safety.

In addition, compared with the same-class models [Wenjie M9 (price of 469.8-569.8 million yuan) and Ideal L9 (price of 409.8-439.8 million yuan)], Deep Blue S09 provides the same level or even higher car experience as the same-class models at the price range of 23.99-30.99, and its overall performance deserves a big "praise".

Of course, whether any vehicle is suitable for you and your family members, you need to bring your family to experience it together!

Special feature of 1905 film network On January 17th, 2018, the film was officially opened for pre-sale, with a final pre-sale result of 294 million yuan, which still maintains the highest pre-sale result in China film history.

In the end, last year’s Spring Festival file closed perfectly with 1.277 billion box office and 6.4 billion total box office on New Year’s Day.

　

So what about 2019?

　

In the eyes of many people, this year is the strongest Spring Festival file in history.

　

"Shen Teng vs Shen Teng", "Liu Cixin vs Liu Cixin" and "Jackie Chan vs Stephen Chow" … … It is still difficult to draw a conclusion as to what the final outcome of the king-to-king war will be.

　

Last Thursday (January 10th), it was the first to open the pre-sale. Six days later, on the first day of 2019, the box office exceeded 100 million, and there were still 17 days before the film was released.

It is not a special signal that the total box office of pre-sales has exceeded 100 million now, but only two of these films have pre-sales close to 30 million, which is a very obvious decline compared with the same period last year — — The pre-sale result of "Catch the Demon 2" is close to 60 million 16 days in advance.

　

No wonder, some people assert that this is perhaps the most chaotic Spring Festival stall in history.

　

Except for the nine films that have been pre-sold, the high-profile new year’s day and the new year’s day have all been followed up, and the two official Weibo updates have no substantive content for nearly half a month.Suspected to withdraw from the Spring Festival competition.

(Two pieces are suspected of exiting the Spring Festival file)

There are actually four key problems in the competition pattern of this year’s Spring Festival stalls:

　

1. Last year’s total box office was 6.4 billion. How much will the market increase this year?

　

2. How many box offices can the pre-sale of 19.9 yuan stimulate in 2019 when the ticket is no longer available?

　

3. Last year, from the third echelon of 11.4% of the films, all the way to the first echelon, then who will be "unexpected" this year?

　

4. Can a series of atypical Chinese New Year blockbusters in Love Saint 2 break through, or are they "acclimatized"?

　

Last year, five feature films and one animated film finally produced two over 3 billion, one over 2 billion, one over 727 million and one over 600 million, and also won 170 million. This has greatly inspired domestic blockbusters to abandon the December Lunar New Year file and get together to choose the Spring Festival file.

So, can this year’s 7+2 be greater than last year’s 5+1?

　

Judging from the current pre-sale results and the desire index of each platform, it is obvious that the head films of this year’s Spring Festival file are "Flying Life", "Crazy Alien" and.

The ticketing platform wants to see the index

Nowadays, the single-day box office pre-sale has exceeded 100 million, and these three films are still pulling each other, especially the first two works, and the box office gap between them has been maintained at around 1 million.

　

However, compared with the pre-sale results of "Catch the Demon 2", there is still a long way to go at the box office.

　

Why is this happening?

　

The answer is obvious. When the strong meet, it is easy to divide the box office in the early stage. These two films are starring Shen Teng. After two years of polishing of Mahua FunAge films and frequent variety shows, Shen Teng has become another national comedian after Bo Huang.

Bo Huang, another star of Crazy Alien, although only one film met the audience in the past year, its box office appeal has not diminished.

The king versus the king, the audience is naturally prone to indecision.

In the past Spring Festival files, Stephen Chow and Jackie Chan have always been the easiest to sink the attribute of "family fun".

In 2017, although leading all the way, it was eventually overtaken. But in fact, the word-of-mouth difference between the two is not big, just because Kung Fu Yoga is more in line with everyone’s understanding of Jackie Chan movies and meets the needs of the audience.

But this year, the performance of Stephen Chow’s works and Jackie Chan’s works in the pre-market seems to be unsatisfactory.

　

At the same time, compared with the co-marketing of various brands of "Catch the Demon 2" last year, several films this year are relatively weak. Apart from the conventional material promotion and the mode of inviting popular idols to participate in the propaganda song, there is no particularly big movement for the time being, which also leads to the fact that the propaganda is not sinking better.

Of course, sinking seems to be a relatively paradoxical word for the Spring Festival. A large number of "homecoming tides" are difficult to define the audience’s taste, but the success of pre-sale in the third, fourth and fifth tier cities is still the most critical factor in the film.

　

Last year, the successful ticket replacement helped the pre-sale of the film in the early stage, and at the same time won enough market space for the single film. Nowadays, the pre-sale results seem to be declining gradually, but the ticketing platforms such as Cat’s Eye and Taobao Film still advertise "preferential ticket purchase from 19.9 yuan", and "internet plus Movie" is still the key to the current movie market.

However, since last year’s Operation Red Sea, more and more films have relied on word-of-mouth counterattack, and after the incident, the pre-sale box office has lost some persuasiveness.

Especially for the special schedule of the Spring Festival, the movies in this schedule have a fresh life of nearly half a month. Although there are occasional films released on the eighth day of the seventh day, it is difficult to defend the films within the schedule.

　

Dating back to 2014, at that time, the atmosphere of "watching movies for all" rose, and even it was able to counterattack and create a box office miracle. It seems that any film can get a bowl of soup, and word-of-mouth and box office do not seem to be particularly related in this schedule.

2015 Spring Festival box office

In addition, since 2016, the film market has begun another very important word-of-mouth marketing: emotional marketing.

　

Under the slogan of "owing Stephen Chow movie tickets", The Mermaid snapped up 3.38 billion yuan.

2016 Spring Festival box office

Finally, the film quality of The Mermaid failed to meet the expectations of Stephen Chow fans. The next year, when "A Journey to the West" took this as a stunt again, the effect was obviously discounted.

In 2019, Stephen Chow relied on the classic IP to bring "New king of comedy", and the publicity materials featured "Stephen Chow’s Works" from beginning to end. But judging from the current popularity, the audience began to hesitate.

2017 Spring Festival box office

While the film market in China is developing faster and faster, it is also undergoing a transformation from fast to strong. The audience is rational. In the Spring Festival of 2018, word-of-mouth successfully restricted the box office, making it difficult to break 1 billion, while the "Nineteenth Generation of Ancestors" with a pot of stew missed the box office of 200 million. Operation Red Sea, by virtue of word-of-mouth, fought back from the third echelon, which ranked 11.4%.

Operation Red Sea platoon film all the way back.

It can be seen that any film may become a "dark horse" through word of mouth.

With Operation Red Sea Zhuyu in the front, the so-called "family fun" is no longer the key to the success of Spring Festival movies.

Operation Red Sea has always been the benchmark, and the producer behind it, Beijing Culture, is very good at word-of-mouth marketing. As long as the quality of the film can pass, this film with the banner of "China’s first hard science fiction" may be countered.

Of course, the key to the counterattack is that the quality of other films can not fully meet the expectations of the audience. But as far as the current materials are concerned, the strength of The Wandering Earth’s opponents is quite strong, and it is not difficult to counterattack.

Of course, when it comes to counterattack, Han Han is indispensable.

Han Han’s first two works have been countered in the summer vacation and the Spring Festival, and they are among the 1 billion box office clubs. Han Han’s films have always had their own unique style. Now, when he comes to Shen Teng to join us, as long as he can maintain the level of his previous works, the performance of Flying Life will not be too bad.

Let’s look at Crazy Alien, the arch-rival of Flying Life, which has assembled three actors who are highly recognized by the whole people, Shen Teng, Bo Huang and Xú Zhēng. In addition, Ning Hao has been focusing on word-of-mouth cards in recent years.

In terms of quality assurance, the word "Ning Hao’s Works" seems to be much more convincing than "Stephen Chow’s Works".

On the other hand, Jackie Chan seems to have been pursuing transformation after Kung Fu Yoga. This time, he also abandoned martial arts and became a literary giant Pu Songling.

However, this time there is not much advantage in the "starting line", but it must be admitted that Jackie Chan’s audience in the Spring Festival file has been very stable. Judging from the current preview, it seems to be the film with the most "family fun" attribute among several works.

In fact, it was Jackie Chan who first created the concept of New Year’s films across the Taiwan Strait and three places. In the past Spring Festival files, his modern fashion films were the first at the box office. Now the biggest attraction of Detective Pu Songling may be whether Jackie Chan can continue to support his box office appeal after the transformation.

In addition, the two films "Integrity" and "Lover 2" don’t seem to have too many advantages. Judging from the performance of similar themes in other important schedules,"Lover 2" may become a "BlackHorse "As for how much room it has to move forward, it may depend on the follow-up word of mouth.

Relatively speaking, the animation market is relatively stable. "Bears haunt" series has always been the most domineering animation IP in this schedule, but this year, there will be some variables.

　

Although "Piggy Peggy’s New Year" is a young movie, it appears in the mode of real person and animation. Whether children can pay the bill in the end may be the most important key point in its marketing.

It can be seen that this year’s Spring Festival file is very cruel, just like the left and right hands fighting each other. What will happen in the end? In fact, Xiao Dianjun is hard to predict, and the final result may surprise everyone.

　

Return to the overall situation, is it possible to expand the market? Xiao Dianjun believes that there is still some.

　

Looking back over the past three years, the total number of people watching movies on the first day of the National New Year has increased from 17.67 million in 2016 to 32.63 million last year. At the same time, the number of movie screens in China continues to grow, and the number of people who can watch movies is increasing. There is still room for expansion in the natural market.

Just where is the ceiling for expansion? Perhaps the decisive factor is the film itself.

The couple, who are in love with their grandmothers, accept everyone’s blessing.

　　On September 28th, Delfa Vapes, an 82-year-old Argentine woman, married Renaldo Wavyk, a 24-year-old handsome guy, which once shocked Argentina. After only 25 days of marriage, Delfa suddenly died of a heart attack on the 22nd!

　　The sudden death of Delfa, the old bride, caused a sensation in Argentina again. Some people suspect that the groom Renaldo did not hesitate to "murder for money" in order to get the old lady’s inheritance as soon as possible.

　　"Grandmother-in-law Love" is 58 years old

　　The groom, Renaldo Wavyk, is 24 years old and an unemployed man in Santa Fe, the capital of Santa Fe province in central Argentina. The bride, Delfa Walpes, is 82 years old. She has never been married before, and she has no children or daughters around her. She has already retired for many years.

　　According to reports, the love affair between them began nine years ago. After the death of Renaldo’s mother at the age of 15, Delfa, a great friend of Renaldo’s mother, took the initiative to invite the "little boy" to live with him. Who knows, the two had a long relationship.

　　On September 28th, the 58-year-old couple held a grand wedding in Santa Fe, which caused a sensation in the whole country. The media in Brazil, Spain, Chile and other countries reported on this shocking wedding.

　　At that time, a reporter asked Delfa curiously: "Is this marriage just spiritual?" The 82-year-old bride replied politely, "No, it won’t be just spiritual. There will be many more."

　　Only 25 days, the "old bride" died suddenly.

　　After the wedding, the couple accepted the invitation of the municipal government of Rio de Janeiro, Brazil, and went to Brazil for their honeymoon. After that, they also plan to travel to Spain and be interviewed by a local TV station to tell their love story. But surprisingly, on October 22nd, shortly after they returned from their honeymoon in Brazil, the old lady Delfa died of a heart attack!

　　According to the doctor in charge of her treatment, Delfa’s health began to deteriorate since she got married on September 28th. On October 18th, when she and her husband returned home early, Delfa suffered a heart attack and was sent to the intensive care unit of the local sanatorium in Santa Fe.

　　On the morning of the 22nd, she developed complications such as dyspnea and severe pneumonia, and finally died because of ineffective rescue. On the 22nd, a close friend of A Delfa said sadly: "A Delfa said before her death that although she only enjoyed 25 days of marriage in her life, everything in her life has changed wonderfully in the past 25 days."

　　The little groom "murdered for money"?

　　Since she has no children, Delfa, the old lady, has transferred all her property to the name of "Little Husband". At that time, all kinds of speculations were rampant. It is speculated that the groom Renaldo wanted to get the legacy of the old lady Delfa at an early date, and he did not hesitate to "murder for money".

　　Renaldo said that his wife’s unfortunate death made him feel extremely sad: "I can’t accept the fact that I have lost her. I’m not interested in what others say. What I like is only a’ mature woman’. If I only married her for material reasons, then it’s not necessary, because she has already donated all her property to me. There is no one else around her, and the only relative is me. " Yuan hai

Editor: Fan Jing

　　From May 21st to June 13th, 19 enterprises including () (603392.SH), () (605337.SH) and () (300485.SZ) successively indicated on the investor platform that there was no synthetic biology related business or application (see Figure 1) for the time being, mainly because there was no technical reserve or none.

　　In sharp contrast to the cautious attitude of these enterprises towards synthetic biology, in the last two months, the concept stocks labeled with synthetic biology in the secondary market have soared.

　　The data shows that in the past 60 days, nearly 40% of the 27 synthetic biology concept stocks have risen. Among them, () (301301.SZ), () (603739.SH) and () (002773.SZ) led the way, with increases of 39%, 29% and 29% respectively. Seven stocks rose more than 5% (the opening price on June 18th).

　　This large group increase in share prices is considered to be driven by favorable policies. At the end of April, at the annual meeting of Zhongguancun Forum, Tan Tianwei, an academician of China Academy of Engineering, emphasized that bio-manufacturing is a very important new track and new format for new quality productivity. Led by the National Development and Reform Commission, the Ministry of Industry and Information Technology, the Ministry of Science and Technology and other national ministries and commissions are jointly developing a national action plan for biotechnology and bio-manufacturing, which is expected to be introduced in the near future.

　　Synthetic biology is not a new concept, it was first born in early 2000, and it is considered as the "third life science and technology revolution" after the discovery of DNA double helix structure and the human genome project.

　　To put it simply, the way of synthetic biology is to transform the genes of microorganisms such as bacteria, so that they can produce raw materials needed by human beings in metabolism, such as plastics, food or medicines, which can be applied to medical treatment, environment, health, energy, food, agriculture and other industries. This mode of production is often more environmentally friendly than traditional chemical methods, or it can produce new products that cannot be realized by chemical methods.

　　This is not the first time that synthetic biology has set off a market boom. The last wave of capital influx was in 2021, when there were 458 financing events in the field of synthetic biology in China, and the financing amount reached 113.6 billion yuan, all of which were the highest level since 2019.

　　At that time, Ginkgo Bioworks and Zymergen of the United States successively landed on NASDAQ. Both companies are platform-based enterprises that provide synthetic biology technology, and their listing also drives domestic hot money to flood into synthetic biology start-ups.

　　However, in less than three years, the three giants of American synthetic biology were almost wiped out, and the related investment and financing also fell to freezing point.

　　Amyris, the world’s first synthetic biology listed company, was once famous for producing artemisinin by using synthetic biology technology. However, after the development of bio-fuel products failed, it expanded its cosmetics raw materials and other businesses on a large scale, and its debts snowballed until the bubble burst, and it went bankrupt and liquidated in 2023.

　　Also in 2023, Zymergen went bankrupt. At first, it only focused on the development of strains. Later, it turned to the development of products, and chose an optical film Hyaline, which can be used in electronic products such as folding screens. However, mass production failed, and the entire synthetic biology sector in the United States plummeted. Zymergen was acquired by Ginkgo Bioworks after bankruptcy.

　　However, the surviving Ginkgo Bioworks is hard to say success. They insisted on making technology instead of products, and their market value fell by 92%, and their stock price was as low as 0.99 US dollars. In May 2024, they received a warning of delisting.

　　Industry martyrs have proved with painful reality that the concept of synthetic biology is very popular, but it is difficult to do business in this crater-selecting products, mass production, and developing business models. One wrong step may lose the game.

　　Who is the real synthetic biology enterprise?

　　Many practitioners said that enterprises in China are concentrated in the downstream field of synthetic biology, product-oriented, and there are few platform-based enterprises that provide technology.

　　A reference perspective is that, as an instrument supplier, synthetic biology is one of the fastest growing sectors of Agilent’s business in China, and its customer business focuses on bulk chemical raw materials, food additives, pharmaceutical and cosmetic raw materials.

　　Figure 2 shows the top ten companies in the synthetic biology concept stocks, and they are also the players that the market thinks are more promising, including Huaheng Bio (688639.SH), Huaxi Bio (688363.SH), Tebao Bio (688278.SH), Kaisai Bio (688065.SH) and () (600298.

　　These enterprises entered the field of bio-manufacturing earlier and firmly occupied the leading position in the subdivision track.

　　Huaheng Bio’s global market share of alanine exceeds 50%; Huaxi Bio is the largest supplier of sodium hyaluronate in the world, accounting for 44%. The long-chain dibasic acid produced by Kaisai Bio-accounts for 90% of the global market share.

　　Companies with stock prices in the top ten generally have two characteristics: one is mature products, and the other is rich experience in mass production.

　　A technician who has been engaged in synthetic biology research for many years said that when a company has made clear the synthetic biology methods used, it still needs to solve the problem of mass production. This is called "crossing the Death Valley from lab (laboratory) to fab (factory)" in the industry, and it will be scaled up to the industrial level after small-scale and pilot-scale tests.

　　In the research and development stage, the screening of strains is the key, and the characteristics of chassis cells should be studied for many years. In industrial scale-up, it is necessary to control fermentation temperature, time, dissolved oxygen and miscellaneous bacteria pollution more precisely, and the difficulty coefficient increases exponentially. After the problems appear, we should go back to the most basic strain optimization, reconstruct the metabolic pathway, and repeat it many times to achieve a breakthrough in strain tolerance and yield.

　　Gong Mo, general manager of Lingdao Capital, vividly explained the differences in each stage. It takes several years or even more to do basic research in the laboratory, and it is enough for a doctor to graduate after entering the pilot stage, which requires at least five years and tens of millions of dollars. It’s not a sudden idea that can be realized immediately. She said that investors are more optimistic about the team with long-term experience in basic research and industrialization. This kind of industrialization experience is best accumulated in downstream separation, extraction and purification.

　　Different industries have different definitions of "mass production". For example, the overall demand for cosmetic raw materials is small and the unit value is high. Therefore, the pilot scale is kilograms per year and the mass production is tons. For the chemical and material industries with large demand and low unit value, the pilot scale is at least 1,000 tons, and the mass production is calculated based on an annual output of one million tons.

　　The ability of mass production is so critical that after the concept of synthetic biology broke out in 2021, many enterprises raised funds mainly for building new industrial lines and expanding production capacity.

　　See the direction of the enterprise from the location of the new factory. In coastal areas such as Yancheng, Tianjin and other places, factories are mainly built by enterprises with small mass production scale and products going to sea. There is sufficient wind power in the local area, which is convenient for export and sales near ports. Enterprises with larger production capacity will directly choose places such as Xinjiang and Inner Mongolia where raw materials such as electricity, energy and corn are cheaper.

　　Among the concept stocks, Huaheng Bio has completed the expansion of Qinhuangdao and Bayannaoer bases, with the current production capacity of 100,000 tons and 50,000 tons. In addition, it has built a new material production base with a production capacity of 100,000 tons in Chifeng, Inner Mongolia.

　　Kaisai Bio’s 100,000-ton bio-based polyamide production line in Wusu production base in Xinjiang has been put into production. Huaxi Bio’s Tianjin plant has been put into production, and 64 pilot production lines are planned to be built. The overall production capacity of bioactive materials is planned to reach 1,000 tons.

　　Among the synthetic biology concept stocks, most enterprises are still in the initial stage of layout.

　　For example, Angel Yeast’s subsidiary Weiqi Enterprise, with an annual output of 10,000 tons, is under construction, and the first phase is planned to be put into production in 2025.

　　Azure Bio, whose daily limit has been raised for many times, shows that the enterprise has only set up a synthetic biology technology innovation laboratory, which is still in the research and development stage of the early strain laboratory and does not have the conditions for industrialization.

　　Product homogeneity is serious.

　　Synthetic biology is still in the early stage, because people’s understanding of the biological field is less than 10%, which brings a common phenomenon in synthetic biology enterprises-product homogenization.

　　The involution of cosmetic raw material enterprises is particularly serious.

　　There are more than 40 synthetic biology enterprises engaged in the development of cosmetic raw materials in China. Many start-ups and listed companies have plunged into squalene, ergothionine, icodoline and other popular raw materials with moisturizing and antioxidant effects.

　　At present, the listed companies with mass production capacity in China are mainly Huaxi Bio and Chuanning Bio. Ultra-pure ergothionine produced by Huaxi Bio-technology has a purity of over 99%. At the end of May, Chuanning Bio announced that some synthetic biological products have entered the stage of small-scale and pilot-scale, including squalene, ergothionine, and icodoline.

　　The aforementioned technicians believe that when making the same product, the volume concentration, volume purity, volume impurities, etc. really make the quality of raw materials better, and also knock down the original inflated price. For example, the price of ergothione was 200,000 yuan/kg a few years ago, and now it is only tens of thousands of yuan/kg.

　　However, cosmetics raw materials are a relatively small market, and the enterprises that enter the market first will have advantages, and most of the enterprises that enter the market later can only fight price wars, or suffer heavy losses because of drastic price changes.

　　In February this year, Sinochem, one of the earliest enterprises that made ergothionine, declared bankruptcy. The enterprise was founded in 2016, when there were almost no enterprises that produced ergothionine in China.

　　According to public information, Zhongke Nuozhi and Tianjin Institute of Industrial Biology, China Academy of Sciences agreed to realize the industrialization of ergothionine within 4 years after it passed the verification level of 75L fermentor, which means that it should be produced in at least 1000L fermentor.

　　However, in 2020, which was supposed to be the test result, Zhongke Nuozhi suffered a triple blow from inside and outside: it failed to mass produce, the price of ergothionine began to decrease, and it was deeply involved in various judicial cases and disputes.

　　In this year, the number of judicial cases involved in Kono Knowledge exceeded 60, which was the highest in the past years, including private lending disputes, patent transfer contract disputes, service contract disputes, labor disputes and so on. A year later, the court ruled that Kono paid R&D expenses and breach of contract fees, and transferred the development patent back to Tianjin Institute of Technology.

　　The bankruptcy of Zhongke Nuozhi shows the other side behind the scenery of synthetic biology track. The market turmoil and the ability of enterprises to land can directly determine life and death.

　　In addition, for some products, even if the price is lowered by the method of synthetic biology, it can not stimulate demand, and it is a waste of production capacity to be involved, so the forward-looking selection of products by enterprises is particularly critical.

　　For example, Glutathione, a raw material drug with the functions of protecting liver and whitening, is quoted at a price of about 800 yuan/kg-900 yuan/kg by using traditional yeast, and () (300233.SZ) occupies about 90% of the market share in China. Glutathione produced by synthetic biological process is quoted at about 600 yuan/kg-700 yuan/kg, but Jincheng Medicine still occupies 90% of the market.

　　This is because, on the one hand, the price drop is relatively low, which has not impacted the market; on the other hand, the change of pharmaceutical raw materials needs to be reapplied for approval, and the process is very complicated. Safety and stability are more critical factors than cost.

　　To sum up, there are two reasons for the homogenization of involution products in synthetic biology enterprises:

　　First, the raw materials of cosmetics are mainly small molecular compounds and monomer materials. At present, both the research on the characteristics of chassis cells and the environmental control of mass production are very mature. If the price in the market is high, more enterprises will flock to do it.

　　Second, China’s current policies are relatively stricter in food, medicine, agriculture and other fields. For example, the longest approval period for biological pesticides can reach 8-10 years.

　　Many practitioners said that the standards committee related to synthetic biology in China is gradually being established, and the access and process of approval will be improved in the future. However, what determines the profitability of enterprises at present is the ability to expand diversified product lines and find materials with a wider range of applications through long-term research and development.

　　Dong Lei, dean of the School of Life Sciences of Nanjing University, told the Economic Observer that the focus of synthetic biology around the world is mainly on the synthesis of small molecules, but not on macromolecular materials, because the synthetic steps involved are more complicated and difficult.

　　New materials, new business

　　Many enterprises that started earlier are also producing macromolecular materials based on synthetic biology. The leading ones are polymers in the chemical industry, such as PHA (polyhydroxy fatty acid ester, note: a kind of bio-polyester, which has degradable characteristics) and polyamide materials (nylon).

　　In the past, chemical companies such as Kaisai Bio and Huaheng Bio mainly sold small molecular monomer materials such as dibasic acid and alanine. They made them by biological method instead of chemical method, which reduced the cost and seized a larger market share.

　　It is difficult to reduce the short-term cost of macromolecular new materials, and the market has not been widely accepted, so enterprises are also exploring new business models. The most representative is that raw material enterprises directly go off to build brands or jointly manufacture products.

　　Many synthetic biology enterprises have flocked to PHA racetrack. This material has good biocompatibility, biodegradability and thermal processability, and can be applied to food packaging, fiber fabrics, agricultural mulching films, drug delivery and medical materials.

　　Blue Crystal Microbes is one of the start-ups with the most financing in synthetic biology. Since its establishment in 2016, it has completed 10 rounds of financing and disclosed that the total financing amount exceeds 2 billion yuan.

　　Li Teng, co-founder and president of Blue Crystal Microbes, told the Economic Observer that they have been doing PHA since its establishment, providing only technical services and not making products. It is difficult for start-ups to survive. If they only make popular products at the moment, they will be eliminated in a few years.

　　Li Teng said that at first, their definition of PHA was a fine chemical, but now it has changed into a bulk chemical. He explained that this adjustment is market demand-oriented. Unlike other enterprises, blue crystal microorganisms hope to use the same PHA to meet different needs. Blue crystal PHA is made because it has the greatest potential for cost reduction, the highest product adaptability, and the corresponding technical difficulty is higher. Stability and quality are the most priority factors, followed by cost.

　　The direct profit of Blue Crystal Microbes is to cooperate with brands and manufacturers to jointly develop PHA products, including disposable products, soft and hard packaging, textile fibers and so on. The annual production capacity of blue crystal PHA is 5000 tons, and the output of downstream products is 5000 tons, which belongs to the first echelon among PHA manufacturing enterprises at home and abroad.

　　In addition, cyanobacteria also develop in the middle and upper reaches, providing platforms and technologies to incubate small enterprises.

　　Li Teng said that in the past, they only produced products, but now it may be a turning point. They have observed that more and more small enterprises are also entering. However, the capabilities provided by incubators and biomedical sharing platforms on the market are different from the actual needs.

　　For example, most synthetic biology laboratories usually emphasize the automation of Qualcomm quantity, but most strain development processes do not need Qualcomm quantity, which is different from drug research and development, which needs to screen many different molecules. Therefore, Blue Crystal is helping small enterprises to improve efficiency through its own experience, such as technical services and laboratory sharing.

　　As the leading supplier of long-chain dibasic acids in the world, Kaisai Bio is also the first enterprise in the world to realize bio-based polyamide (note: dibasic acids and diamines are important monomer raw materials of polyamide). The pilot test of this material was completed in 2014, and the production line with an annual output of 100,000 tons was completed and put into production in 2021.

　　Although the production capacity has increased significantly, the actual sales volume has increased less.

　　According to the prospectus, from 2016 to 2021, the sales volume of bio-based polyamide increased from 0.5 million tons to 0.7 million tons, and the ratio of production to sales was always around 50%. In contrast, the sales volume of long-chain diacid, the ace product, increased from 25,000 tons to 61,000 tons.

　　According to Kaiser Bio, bio-based polyamide is a brand-new material, its price is higher than that of nylon made by chemical method, and its application ability is still being explored.

　　Bio-new materials made of new polymer materials need to provide a whole set of solutions, tell customers how to process and produce, jointly research and develop with downstream, and even assist customers in carbon footprint, equipment and technology, so as to make the market accept them faster. In this regard, Kaisai Bio has established an interdisciplinary R&D center, which has made remarkable progress in the textile field, engineering materials and composite materials.

　　In addition, Kaisai Bio has established its own fiber brand TERRYL to provide fiber solutions for the textile field.

　　For example, we cooperated with Bosideng’s brand Samet to build school uniforms, and cooperated with close-fitting clothing brands such as Shushu and Ubras to develop underwear, sportswear, yoga clothes and other kinds of clothing. At the same time, we replaced the consumables such as work clothes, helmets and carpets in the internal production base with new materials.

　　Liu Xiucai, chairman of Kaisai Bio, once publicly stated: "We can’t make the business model of synthetic biology too early." In the future, there may be a model similar to the pharmaceutical industry. A startup or research institution has made an efficient and valuable metabolic pathway, but it does not do follow-up research and development, and packages the results and sells them to mature enterprises in the industry to complete it.

CCTV News:Spring Festival travel rush ends on February 22nd, 2025. According to the data from the comprehensive transportation Spring Festival travel rush working class in 2025, in 40 days in Spring Festival travel rush, the cross-regional personnel flow of the whole society was 9.02 billion person-times, an increase of 7.1% over the same period in 2024.

Among them, the number of railway passengers sent was 510 million, a year-on-year increase of 6.1%; The turnover of highway personnel was 8.39 billion person-times, a year-on-year increase of 7.2%; The number of passengers sent by waterway was 31.21 million, a year-on-year increase of 7.6%; The number of passengers sent by civil aviation was 90.2 million, a year-on-year increase of 7.4%.

Inventory in Spring Festival travel rush in 2025: The "ice and snow fever" traffic in the north and south helps the ice and snow tour.

This year’s Spring Festival travel rush also presents a feature: whether it is cold in the north or warm in the south, there has been an ice and snow tourism fever.

The hosting of the Asian Winter Games has heated up the "two-hour" and "three-hour" economic and tourism circles with Harbin as the center. Domestic air ticket orders with Harbin as the destination increased by over 20% year-on-year, and hotel bookings increased by nearly 60% year-on-year. The cumulative reception of inbound tourists in Harbin increased by 144.7% year-on-year.

A major feature of Spring Festival travel rush this year is that ice and snow tourism fever has appeared in many places in the north and south of China. The data shows that the hotel booking fever in Altay, Yili, Qitaihe, Heilongjiang and Xilin Gol, Inner Mongolia in the north increased by more than 40% year-on-year. The search heat of ice and snow consumption in Shanghai, Zhejiang, Guangdong and other places in the south has more than doubled.

In order to cope with the ice and snow tourism fever, this year, Spring Festival travel rush, the railway departments around the country increased the frequency of trains running between the hot cities of ice and snow tourism. Railway and transportation departments around the country have opened up the "fast lane" of ice and snow tourism, realizing the seamless connection between railway stations, bus stations and ski resorts. In view of the surge of tourists going to Shangri-La, Yunnan for skiing, Yunnan Railway Department has started tourist trains from Xishuangbanna, Kunming, Dali and other popular tourist cities to Lijiang, and then the tourists will transfer to the EMU train from Lijiang to Shangri-La, which will go directly to Shangri-La. Xiamen, Fujian opened the first ice and snow theme train to Harbin.

Wu Zhenbin, the stationmaster of Xiamen North Station of Nanchang Bureau of China Railway, said: "We have designated a waiting area for group passengers in the waiting room and arranged special escort services to make the elderly groups travel steadily and feel warm."

　　Beijing Procuratorate Daily, August 26th (Reporter Xie Wenying) "164 votes in favor and 3 abstentions". On the morning of August 26th, the 12th meeting of the 13th the National People’s Congress Standing Committee (NPCSC) voted to pass the newly revised Drug Administration Law. The highlight of the revision is that the scope of counterfeit and inferior drugs has been revised, and drugs imported without approval have not been classified as counterfeit drugs. At the same time, respond to questions such as whether the network can sell prescription drugs.

　　Because China has not implemented compulsory license, some cancer patients are still "illegally" buying foreign generic drugs to save themselves. The experience of Lu Yong, a leukemia patient in Dying to Survive, is a true portrayal of this situation. In order to alleviate the contradiction of "expensive medical treatment" among the people, and let the public use good drugs more quickly and afford good drugs, the State Council requires speeding up the examination and approval of new drugs listed overseas and strengthening the supply guarantee of drugs in short supply, which are all reflected in the newly revised Drug Administration Law.

　　Yuan Jie, director of the Administrative Law Office of the Legal Affairs Committee of the National People’s Congress Standing Committee (NPCSC), said at today’s press conference that the import of drugs from abroad must be approved, which is a rule and principle made by law. Drugs that have not been approved, even those that have been legally listed abroad, cannot be imported. This time, the scope of counterfeit and inferior drugs was revised, and drugs imported without approval were no longer classified as counterfeit drugs, which was a response to the concerns of the people. The newly revised Drug Administration Law stipulates that if the circumstances are minor, the punishment may be reduced or exempted for importing a small amount of drugs legally listed abroad.

　　"It is not the same as reducing the punishment to take drugs imported without approval out of counterfeit drugs and stipulate them separately." Yuan Jie said that the law has strictly set legal responsibilities, and the production, import and sale of counterfeit and inferior drugs without obtaining the drug approval documents are still punished according to the production, import and sale of counterfeit and inferior drugs.

　　To implement the drug administration law well, the responsibility of the regulatory authorities should not be underestimated. Yuan Jie said that in the chapter on supervision and management, it is stipulated that if the drug supervision and administration department finds that a drug violation is suspected of committing a crime, it shall promptly transfer the case to the public security organ. The public security organ, the people’s procuratorate and the people’s court shall promptly transfer the case to the pharmaceutical supervisory and administrative department if there is no need to pursue criminal responsibility or be exempted from criminal punishment according to law, but administrative responsibility should be pursued.

　　There is a high degree of social concern about whether prescription drugs can be sold online. In this regard, the newly revised Drug Administration Law also responded. Liu Pei, director of the Policy and Regulation Department of National Medical Products Administration, said that the current law clearly stipulates that prescription drugs cannot be sold directly to the public through the Internet, and the revised Drug Administration Law stipulates the principle of comparison in selling drugs through the Internet, that is, it requires the drug sales through the Internet to comply with the relevant provisions on drug management, and authorizes the drug supervision and administration department of the State Council to formulate specific measures in conjunction with the health authorities of the State Council and other departments, and stipulates that several types of specially managed drugs cannot be sold online.

　　The newly revised drug administration law will come into effect on December 1 this year.

Ready Player One

Special feature of 1905 film network After four days of release, the box office was 450 million, and the Douban score soared to 9.1.

Completely fired!

This film is adapted from the novel of the same name by the otaku Ernst Klein, and there are hundreds of game movies.

I really can’t think of a more suitable candidate than Spielberg to turn such a book into a blockbuster.

Cover of Ready Player One’s original novels in English and Chinese

Ready Player One is indeed a bestseller and has been translated into 20 languages. However, it caters to some people’s feelings, and at the same time, it is also considered by some readers as "otaku’s cool writing".

Among readers all over the world, some people dislike this book, and some people call it "Wikipedia about the 1980s" — — That is, those eggs are useless for narrative, and the only value is to let readers pat their thighs: ah, I know this!

At that time, Xiao Dianjun was made to want to throw a book by its narrative way of constantly throwing stalks.

The original author was called "the sexiest geek on the planet today" by USA-Today.

But when Spielberg first read this book, he was shocked by the author’s foresight for the future through these stalks. In order to make more people accept it, he injected what he was good at into this "history of popular culture in the 1980 s": longing for the future and trembling; Passion for creativity; There is even an inner observation of a lonely and talented boy.

When it was released in the past, the audience queuing to buy tickets filled several streets, and some people watched it several times.

They all want to immerse themselves in such a scene again:

In john williams’s soundtrack, pterosaurs flew across the sky, and giant Tyrannosaurus rex leisurely crossed the grassland. For the first time, people and ancient creatures hundreds of millions of years ago were separated by only one screen, and their hearts must be filled with awe.

After more than 20 years, we are lucky enough to look at a half-gorgeous and half-barren future through a screen, and we are as excited as those people in those years.

These dreamlike experiences are all attributed to Spielberg. A 72-year-old man, a big child.

As a famous director who has filmed the seventh sci-fi film, five of which have become classics in film history, Spielberg’s talent and imagination are well known. However, few people may notice that after close encounters of the third kind, he stopped writing his own plays, but explored and visualized the works of first-class best-selling novelists.

For example, Melissa Mathison, a female screenwriter, was hired for E.T. Alien, and the inspiration came from Kubrick, who wanted to adapt this short story herself.

Stills of E.T. Alien

Today, Xiao Dianjun wants to talk to you about two other classics — — Jurassic Park and, like Ready Player One, they are adapted from famous science fiction.

As one of the greatest directors of commercial films in Hollywood, Spielberg did this … …

　

Jurassic park

Come on, try Spielberg icing?

Jurassic Park is the first sci-fi film adapted by Spielberg, which comes from michael crichton’s novel of the same name.

　

It created a box office miracle.

After the film was released, it won 900 million dollars at the box office and became the highest-grossing film in history at that time. At that time, there was a crazy dinosaur craze, which inspired a lot of movies featuring dinosaurs and monsters, such as Godzilla in Japan.

　

A movie can sell well in a short time, perhaps just because of IP or dazzling special effects technology. But to become a classic, a solid script has become the top priority.

　

Michael crichton, the author of the original novel, is outstanding in his professional level. The man with a bright resume transferred from Harvard Literature Department to Anthropology Department, and also got a doctor of medicine from Harvard. It is precisely because of this hard-core knowledge of anthropology and medicine that his sci-fi thrillers are horrified … … Especially cultured.

　

Michael crichton, the author of the original novel

The most important genetic engineering technology in Jurassic Park was studied in 1970s. In 1984, scientists cloned gene fragments from the fur of spotted donkey 140 years ago, which proved that DNA can be replicated in inanimate biological tissues. Michael has been paying attention to this field. It took him seven years to publish Jurassic Park in 1990.

After the film was made, someone specially asked Paul Barrett, a dinosaur researcher at the British Museum of Natural History, if the film was all nonsense. The researcher replied: "Many scientific theories in the film are actually reasonable. Even the use of frogs makes sense, because they are quite commonly used laboratory animals in this field, and we know their gene sequences very well. Therefore, Jurassic Park was very avant-garde at that time. "

If such a novel is made into a movie, it must be changed greatly. Coincidentally, it met Spielberg — — Hollywood is the director who will sugar-coat all kinds of hard goods to satisfy the curiosity and security of most audiences.

　

What does Spielberg do?

　

His first step is to make the grandma selling tea eggs on the street understand the original professional and obscure words in the book.

　

For example, there is a classic "dinosaur DNA recovery animation" in the movie. What is said in the book is particularly complicated, but it is shown in a way similar to flash in the movie.

Animation explanation version of DNA restoration

　

Secondly, he will use the most advanced technology to revive the dinosaurs he was obsessed with since childhood, and then Amway will give them to audiences who have never been interested in them.

　

Spielberg once said in an interview: "When I was young, I even dreamed of dinosaurs. Therefore, when filming Jurassic Park, I thought more about my childhood memories and fantasies than the original novel. "

　

His favorite is Triceratops. When he saw Triceratops in a museum when he was a child, he sympathized with it. He once fantasized about what happened to it before it became extinct. So he deliberately set up a sick triceratops when he was filming.

He found the most advanced industrial light and magic studio at that time to build dinosaurs with computer special effects, and a small part of them spent huge sums of money to make models. Among them, the mechanical Tyrannosaurus Rex props weigh 12,000 pounds (about 5.4 tons), which can really crush people to pieces when started.

　

Designers also draw materials from various animals for the movement patterns of dinosaurs. For example, the brachiosaurus, the first appearance in Jurassic Park, is the first creature made entirely by computer special effects in the history of cinema. Its action of lifting its legs off the ground and roaring to the sky is taken from an elephant.

Brachiosaurus was taken from elephants.

　

The last layer of icing, which is also the thickest layer, is on the theme and narrative mode of the novel.

　

As many movie fans know, all the series of Jurassic Park add up, and only one tenth of the content of the novel is selected for adaptation.

　

In addition to too much professional knowledge, the original novel is also a dark, pessimistic and cruel world, full of all kinds of bloody and dark fragments as bad as Alien. In particular, the author’s attitude is calm and merciless. He thinks that there is no essential difference between natural creation of human beings and natural creation of dinosaurs. On the contrary, people make their own decisions to become creators, and the consequences they bring must be borne by themselves.

　

Just like the following fragment in the original work, if it is put on the big screen, it is estimated that many parents will stop their children from entering the cinema.

　

“Elena opened the door. The baby is lying in the cradle of wicker, wrapped in a light blanket, and only his little face is exposed. There are three dark black lizards squatting on the edge of the cradle, just like three grotesque statues. When they saw Elena, they looked up at her curiously, but they didn’t run away. In the light of the flashlight, Elena saw blood dripping from their mouths. A lizard barked softly, lowered its head, shook it quickly and tore a piece of meat from the baby’s face. Elena screamed and rushed forward, and the lizards flew into the darkness. However, as early as when she walked to the front of the cradle, she had already seen what the baby’s face looked like. She knew that the child must have died. "

　

Spielberg added a soft lens to the story. A lot of discussion in this part is omitted, and the main line of the film is taken as the story of the ultimate victory of the great escape of mankind, which promotes the brilliance of human nature. After letting the audience experience the thrill, they breathed a sigh of relief in happy ending.

　

In this way, the whole film is no longer sharp, but has played a psychological soothing role for the American audience at that time.

Minority report

Fans will be disappointed, but I am concerned about the future within reach.

If we say Jurassic Park, Spielberg is wrapping a dark kernel with syrup; Then, for Minority Report, what he did was to pick up a knife and carve the original mysterious shape into an angular shape.

　

After the release of Minority Report, its income was 350 million dollars, which was three times its cost. In the Hollywood Reporter’s best list of films starring Tom Cruise in 2016, the first place was Minority Report.

In fact, if Tom Cruise hadn’t recommended it, Spielberg probably wouldn’t have touched the novel at all. When he made this film, he once said: Philip Dick’s novels are not suitable for most movies, and I’m sure die-hard fans will be disappointed with the movies.

　

If michael crichton, the author of Jurassic Park, is an elite science fiction writer, then Philip Dick is a real diaosi geek. He dropped out of primary school, dropped out of secondary school, and was often in financial distress when he grew up. Writing science fiction became a pillar of his life. He started writing at the age of 27 and died at the age of 53. He published 44 novels and 121 short stories in his life.

Philip dick

　

His novels have a unique temperament and a surprisingly wide range of concerns. Unfortunately, when he was alive, most of his novels were published in some cheap science fiction magazines, and he was poor until he was old, even eating dog food for a time; After his death, he was gradually recognized and became the first science fiction writer recognized by the history of American literature. Blade runner, Total Memory, and the previous TV series Electronic Dream: Philip Dick’s World are all adapted from his novels.

　

Minority Report is one of his short stories, which is extremely short and the theme is very obscure. I guess Spielberg had a big head when he got it.

　

So, how to change it?

　

First, add a 50% murder case first!

　

Spielberg once said, "The success of this film depends on the characters 50% and the mysterious murders 50%."

There are only two murders in the novel Minority Report, but there are five murders in the film.

Although the protagonist in the novel is also a captain, he is an old man in his fifties who worries that his young subordinates will rob him of his seat every day. Tom Cruise, the captain of the film, is handsome and strong, with thick hair and bad habits such as taking drugs.

In order to enrich the plot, besides murder, Spielberg also added many action elements.

For example, fighting

Kidnap (a prophet)

The protagonist in the novel has only one core contradiction in the plot, that is, finding a way out, and has no previous history. However, in the movie, the director added a very deadly pre-historical trauma to the protagonist — — His five-year-old son was abducted by a swimming pool and has been missing ever since.

On the one hand, this design is to add key plots; On the other hand, it also aroused the audience’s sympathy for the protagonist who had been traumatized, and better integrated into this plot that was too cold.

　Tom hanks looked at his son’s holographic projection.

　

Second, carefully build a future world

　

Philip Dick’s sci-fi novels are not only full of brains, but also famous for their imprecise techniques, which may be attributed to his extensive interests, but he has never systematically studied science and technology.

For example, some people laughed at him for still using the old TV set … …

Spielberg-style science fiction films, in addition to the complexity of the plot, must also have technology linked to the most cutting-edge technology at present. He is crazy about creating the "future", and he does not hesitate to make great efforts for it.

　

Starting with E.T. Alien, his way is not only to rely on imagination, but also to find experts to dig into details.

Three years after the film started shooting, he found 15 experts in different fields, including architects, novelists, computer engineers, biological scientists, MIT dean and so on, and brainstormed in a hotel for three days.

He wants these people to give him some advice on how to make a future world that is both convincing and different from ordinary science fiction movies. In three days, they actually worked out an 80-page plan, from architecture to technology.

　

Some inventions they came up with in 1999 have actually come true in today’s world.

　

Such as 3D screen, such as iris recognition authentication.

　

Spielberg described his imaginary future world like this: "The Internet is watching us, and the TV is watching us. We lost our privacy. An advertisement will suddenly appear in front of us and talk to us. "

　

Compared with the pessimism in Philip Dick’s novels, Spielberg is an optimist. He is always full of enthusiasm for new technologies that may come. When talking about this film, he once said: "I hope all the small technologies in the film will come true. We will have pollution-free transportation and newspapers that are automatically updated. "

Third, empathize with the audience, not scare them away.

　

The inspiration of Minority Report comes from Philip Dick’s own anxiety about the Cold War. In the struggle between the two great powers in the book, it is like a miracle that a little person wants to find a way out and survive. The whole novel is like a gloomy joke.

In the movie, the core of this story is replaced by the mainstream values of Hollywood, and it becomes a survival story that people should not lose hope under any circumstances and should fight against fate.

Some scary details in the novel have also been changed to more acceptable settings.

　

For example, in the novel, those prophets are actually mentally retarded and squeezed by the government without human rights. But in the movie, it was changed to a normal person, named after several crime novelists. Agatha, led by Agatha, guided Tom Cruise out of danger again and again with the image of "Goddess".

Changed mental retardation into a goddess

　

These changes have undoubtedly reduced the lingering pessimistic background and self-torture in Dick’s novels, and replaced them with Spielberg’s value that "human nature will always find a way out". If reading the original novel is like witnessing the fate of mankind being hung in the air, Spielberg will finally make everyone who watches it land on his feet and be satisfied.

Over the years, all the children who were shocked by such a big film have grown into middle-aged people, and it seems that Spielberg is the only one who hasn’t changed.

In last year’s documentary Spielberg, Xiao Li commented on Spielberg when he was young:

The child in the Arizona desert kept watching TV and movies, and one day slipped into the film company and found his destiny there. This is a touching Hollywood story in itself.

And Daniel Day Lewis said he was old:

We all have a shelf life, and it slipped away without our knowledge. But this may not be the case for Spielberg. He will love his job until he dies.

　

At least from Ready Player One’s point of view, they are all right.

Original transfer network transformation medical network

[Introduction] Cancer-associated fibroblasts (CAFs) are the key components of tumor microenvironment (TME) and play an important role in regulating cancer progression. However, the underlying mechanism of CAFs activation is still unclear.

On April 8, researchers from the Medical College of Kunming University of Science and Technology published a research paper in the journal Cell Death Discovery, entitled "CXC L12 Alone is enough to reprogram normal fibers into cancer-associated fibers". In this study, the researchers found that cancer-associated fibroblasts (CAFs) significantly induced normal fibroblasts (NFs) to acquire the characteristics of CAFs (called CAFs-like fibroblasts, referred to as CEFs for short), including up-regulating α-SMA and vimentin, enhancing the ability of proliferation and migration, and improving the ability of promoting the migration of lung cancer cells. In vivo, CEFs accelerated the growth of A549 xenograft and induced spontaneous lung metastasis. In particular, inhibition of CXCL12 signaling pathway and STAT3 pathway can reduce the transformation from NFs to CAFs, thus inhibiting the progress of lung cancer in vitro and in vivo. This study revealed that CAFs can promote the transformation of NFs into CAFs-like cells through CXCL12/STAT3 axis, and enhance the growth and metastasis of lung cancer. Therefore, inhibiting CXCL12/STAT3 axis is a promising strategy for the treatment of lung cancer and other CXCL12-dependent malignant tumors.

https://www.nature.com/articles/s41420-025-02420-0#Abs1

Research background

01

Cancer-associated fibroblasts (CAFs) are the main components of tumor microenvironment (TME), which promote tumor proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) and drug resistance by secreting growth factors, cytokines and extracellular vesicles, thus promoting tumor development. CAFs is a large number of fibroblasts with α -smooth muscle actin (α-SMA) positive and activated myofibroblast phenotype. Different from normal fibroblasts (NFs), CAFs has stronger abilities of proliferation, migration and contraction. It is generally believed that CAFs mainly comes from NFs where organizations reside, but the mechanism of transforming NFs into CAFs is still controversial.

More and more evidences show that cancer-associated fibroblasts (CAFs) can be activated by signals from tumor cells and matrix environment, which provides a unique insight into the complex interaction in tumor ecosystem. Researchers found that the hardness of extracellular matrix (ECM) can induce mesenchymal stem cells (MSCs) to differentiate into CAFs, thus promoting the invasion and metastasis of triple negative breast cancer (TNBC). In addition, in gastric cancer, CAFs can also "educate" NFs to promote cancer cell proliferation and T cell inhibition. However, the exact mechanism that drives CAFs activation is still largely unknown. Therefore, detailed research is needed to clarify the molecular mechanism of cancer-related fibroblast activation, so as to open up a new anti-matrix therapy approach.

CAFs promotes the transformation from NFs to CAFs in lung cancer.

02

In order to explore the clinical effect of tumor-associated fibroblasts (CAFs) in the process of transforming normal fibroblasts (NFs) into CAFs in lung cancer, the researchers isolated pairs of CAFs and NFs from tumor tissues or corresponding non-malignant tissues adjacent to tumors of several lung cancer patients. CAFs specifically shows highly expressed vimentin and FAP (known CAFs markers), and its ability to promote the migration of lung cancer cells is stronger than that of NFs from adjacent tissues. Then, NFs was treated with CAFs conditioned medium (CM), and then the characteristics of CAFs were analyzed. The levels of CAF markers α-SMA and vimentin expressed in NFs after CAFs CM education increased significantly. These results indicate that CAFs may be helpful to endow NFs CAFs with specific characteristics.

CAFs induces NFs to acquire CAFs characteristics in lung cancer

conclusion

03

To sum up, this study expounds a new molecular mechanism that the interaction between NFs and CAFs promotes the metastasis of cancer cells. CXCL12/ STAT3 pathway is a key participant in NFs-to-CAFs transition, which provides a key therapeutic target for developing new cancer treatment methods.

References:

https://www.nature.com/articles/s41420-025-02420-0#Abs1

Original title: "New Molecular Mechanism! Kungong medical college: an important therapeutic target of new cancer treatment strategy

Read the original text

　　A recent study published in Cancer magazine found that there is an important correlation between socio-economic status and cancer types. Rich and poor people are prone to different types of cancer.

　　For those who are frightened by the news such as "Julie cuts twice every three years" and "Liver cancer can be inherited", please note that this discovery shows that cancer is the result of the interaction between genetic factors and environmental factors in a long process, just like an egg can’t become a chicken without proper temperature, it is mainly environmental factors. Even if you are related to cancer patients, as long as you pay attention to prevention, it is still possible to shut cancer out!

　　Interview expert: Professor Qin Shukui, vice president of Bayi Hospital and director of the Cancer Center of the whole army.

　　1 Carcinogenic environment leads to the distinction between "rich cancer" and "poor cancer"

　　A recent study published in Cancer magazine found that cancer can be divided into "rich cancer" and "poor cancer".

　　In this study, researchers followed up 3 million cancer cases diagnosed in the United States from 2005 to 2009, covering 42% of the population in the United States and covering the richest and poorest communities in the United States.

　　The results show that there is an important correlation between socio-economic status and cancer types. Richer people are more likely to suffer from melanoma, thyroid cancer, skin cancer and testicular cancer; The poorer people are more likely to suffer from Kaposi sarcoma, laryngeal cancer, cervical cancer, penile cancer and liver cancer.

　　Why is this so?

　　The reason is that the causes of cancer (environment and living habits) are different, and eventually different types of cancer will be produced.

　　Cancer is the result of the interaction of heredity and environment.

　　Case: There is a family. The eldest son was admitted to the university and went to other places, and then he stayed to work in other places, while the youngest son stayed with his mother all the time. Later, the mother died of cancer, and then, the youngest son died of cancer.

　　This case shows that there are genetic defects in cancer families, but "common living environment and way" may play an important role.

　　Case: Ms. Leah in Britain divorced her husband because of rectal cancer. She believes that her husband likes red meat, drinks and spicy food, and has a bad temper, insists on smoking and is getting obese year by year. This lifestyle will affect her and her children, and she wants to get rid of this living environment.

　　There is an article in the British Medical Journal detailing "marital diseases", saying that if one of the spouses is sick, the prevalence rate of the other will increase a lot, from cancer, diabetes, hypertension to ischemic heart disease. The reason is that people who live together for a long time have many diseases at the same time because of the same eating habits and similar lifestyles.

　　Modern genetics shows that cancer depends not only on genetic factors, but also on "being affected by acquired carcinogens and cancer promoters". Breast cancer, lung cancer, liver cancer, esophageal cancer, cervical cancer and colorectal cancer are greatly influenced by bad living habits and environmental factors.

　　China also has "poor cancer" and "rich cancer"

　　Case: The 31-year-old "True Water Without Fragrance" (net name) has been feeling intense nausea for more than a month. She usually pays great attention to maintaining her health. She eats miscellaneous grains for breakfast every day, drinks tea and doesn’t touch alcohol and tobacco. She has regular physical examination every year and has never had any major problems. This time, she thought vomiting was a sign of pregnancy, but after a check, the result was: advanced rectal cancer!

　　"True water has no fragrance" slowly pieced together the clues of his illness: although he sometimes eats miscellaneous grains, he eats a lot of meat, and he rarely exercises. He is 155 cm tall but 128 kg fat. At this time, her mother told her that her grandmother died of esophageal cancer, her grandfather died of lung cancer, and an uncle also had rectal cancer!

　　Her grandmother’s esophageal cancer belongs to "poor cancer" and her rectal cancer belongs to "rich cancer".

　　What are the poor and rich cancers in China?

　　"Poor cancer" also includes liver cancer, stomach cancer, esophageal cancer and cervical cancer. "Cancer-rich" also includes lung cancer, colorectal cancer, breast cancer, lymphoma and prostate cancer.

　　4 "poor cancer" is related to long-term chronic infection.

　　Why do liver cancer, gastric cancer, esophageal cancer and cervical cancer belong to "poor cancer"?

　　A study in the Annals of Oncology shows that some cancers can be caused by long-term chronic infection. In China, hepatitis B virus, Helicobacter pylori, human papillomavirus (HPV) and EB virus are the most common infectious and carcinogenic factors.

　　Infected with hepatitis B virus, it further evolves into cirrhosis through acute and chronic inflammation, and a small number of patients can eventually lead to liver cancer.

　　Helicobacter pylori is the most common infectious bacteria, which may cause gastritis and peptic ulcer, and long-term infection may promote gastric cancer.

　　The bane of cervical cancer and its precancerous lesions has been proved to be human papillomavirus infection.

　　The high incidence of nasopharyngeal carcinoma is closely related to EB virus infection.

　　Generally speaking, these cancers related to long-term chronic infection mostly occur in economically underdeveloped areas, where the natural environment is often bad, the nutritional conditions are poor, the hygiene level is low, and the living habits are not good. Therefore, these cancers are easy to develop.

　　5 "cancer-rich" is related to modern lifestyle.

　　Why are lung cancer, colorectal cancer, breast cancer, lymphoma and prostate cancer called "rich cancers"?

　　Rectal cancer with "true water without fragrance" is regarded as a typical "cancer-rich". In terms of pathogenesis, colorectal cancer is influenced by related genes, such as diabetes, hypertension and coronary heart disease. Lifestyle, perennial high-fat diet, lack of dietary fiber intake, sedentary inactivity, untimely defecation or habitual constipation are all common causes.

　　Why excessive intake of high-fat food is one of the carcinogenic factors?

　　A new study found that a high-fat diet can change the intestinal microecology (that is, microbial composition)-some bacteria increase, while others decrease. As a result, the immune defense against intestinal cancer is reduced, and the incidence of cancer is increased.

　　Why sedentary, more susceptible to cancer?

　　The immune function in human body is enhanced with the increase of activity, and sedentary can make the human body lack enough immune cells.

　　An epidemiologist in Canada found that in the United States, 49,000 cases of breast cancer and 43,000 cases of colon cancer are associated with inactivity every year, and breast cancer and colon cancer seem to be two cancers closely related to exercise.

　　Blocking infection can effectively prevent "poor cancer"

　　6 How to prevent "poor cancer"?

　　There is no direct causal relationship between infection and cancer, and it will not be "killed in one blow". Viruses and germs lurk quietly in our bodies, waiting for an opportunity to attack. This process takes about 10 years or more. If we can stop their spread and eliminate them in the cradle, we can effectively prevent the occurrence of cancer.

　　First, get vaccinated. According to statistics, 95% of infants and children in a certain area were injected with hepatitis B vaccine in 1984. Twenty years later, the number of hepatitis B carriers dropped from 10% to 20% to 0.2%, and the incidence of liver cancer decreased by 70% to 80%.

　　Second, early treatment. Helicobacter pylori can be completely eradicated by antibiotic combined therapy, which can not only relieve gastritis and gastric ulcer, but also play a good role in resisting the further development of gastric cancer.

　　Third, do screening. Women over the age of 30 must have regular cervical screening. At the same time, protect yourself, pay attention to using condoms, don’t have sex too early and limit the number of partners.

　　Finally, the dining system. Helicobacter pylori and other germs are highly contagious, and can be transmitted through hands, food and tableware. It is also best to implement a separate meal system in family life.

　　Healthy lifestyle can prevent "cancer-rich"

　　7 How to prevent "cancer-rich"?

　　"Cancer-rich", such as colorectal cancer, breast cancer and lymphoma, has no unique and significant inducement, and some people think it is difficult to prevent it.

　　However, this kind of rich disease also has some common causes-eating too much, eating a high-fat and high-protein diet, and lack of exercise.

　　Therefore, the way to prevent it is to establish a healthy lifestyle. Compared with the "poor cancer" caused by chronic infection, it is more difficult to do and requires greater determination and perseverance! (Li Lanling)

　　CCTV News:On June 15th, the State Council held a press conference on the operation of the national economy in May 2023. Fu Linghui, spokesperson of the National Bureau of Statistics and director of the comprehensive statistics department of the national economy, said at the meeting that from the situation in May, the growth rate of the main production demand indicators has improved to varying degrees. Since the beginning of this year, with the full recovery of normal operation of the economy and society, the previously suppressed production demand has rebounded. Judging from the situation in various countries, there will be a rebound after the economic operation returns to normal operation. With the economic operation gradually returning to normal operation, it will gradually enter a steady recovery trend. Judging from the current situation, due to the low base last year, the economic growth in the second quarter was significantly faster than that in the first quarter. In the third and fourth quarters, with the improvement of the base, the economic operation will return to the normal growth level. From the perspective of the whole year, there are many favorable supports for the economy to achieve its expected development goals throughout the year. There are mainly the following aspects:

　　First, the role of consumption has gradually increased. Since the beginning of this year, China’s consumption potential has been gradually released, and its pulling effect on economic growth is increasing. In the first quarter, the contribution rate of final consumption expenditure growth to economic growth has reached 66.6%. From January to May, the year-on-year growth rate of total retail sales of social consumer goods was 3.5 percentage points faster than that in the first quarter. Service consumption is growing well. From January to May, the national box office revenue increased by more than 40% year-on-year, and the catering revenue increased by 22.6%. During the May 1 holiday, residents’ travel increased significantly, which led to the expansion of related consumption. At present, the overall improvement of the employment situation is conducive to increasing residents’ income and improving their spending power. Various departments actively introduce policies to promote consumption, which will enhance residents’ willingness to consume. The deep integration of online and offline consumption and the accelerated development of new consumption formats and new models are also conducive to expanding consumption. The strengthening of consumption will effectively promote economic recovery.

　　Second, the accumulation of innovation kinetic energy has increased. Since the beginning of this year, China has deeply implemented the innovation-driven development strategy, actively promoted the self-reliance and self-improvement of science and technology, and the development trend of high-end, intelligent and green production is obvious, and the development of new kinetic energy has grown stronger. From January to May, the added value of equipment manufacturing above designated size increased by 6.8% year-on-year, and the production index of information transmission, software and information technology services increased by 11.3%, all of which maintained rapid growth; The output of industrial control computers and systems and polysilicon increased by 33.4% and 84.2% respectively. The pace of green and low-carbon transformation has accelerated, and new energy products have grown rapidly. From January to May, the output of solar cells increased by 53.6% year-on-year, and the kinetic energy of innovation and development increased, which will effectively promote industrial upgrading and development, accelerate the formation of a modern industrial system, promote the transformation of economic growth momentum, and lay a solid foundation for the stable and healthy development of China’s economy.

　　Third, the dividend of reform and opening up continues to emerge. Since the beginning of this year, China has deepened the reform of key areas and key links, actively promoted the construction of a high-standard market system, accelerated the construction of a unified national market, steadily expanded institutional opening, accelerated the creation of a market-oriented and legalized international business environment, vigorously stabilized the trade of traditional trading partners, and actively expanded economic and trade cooperation with RCEP and countries along the Belt and Road Initiative, with continuous results. From January to May, China’s total import and export volume of goods increased by 4.7% year-on-year, and the total import and export volume with countries along the Belt and Road increased by 13.2%. Judging from the utilization of foreign capital, the actual utilization of foreign capital in China’s high-tech industries increased by 12.8% from January to April.

　　In the next step, comprehensively deepening reform, expanding high-level opening up and steadily advancing will inject strong impetus into economic development. Of course, we must also see that the current international environment is complex and severe, the recovery of the world economy is still weak, the spillover effect of policy contraction in major developed economies appears, and there are many unstable and uncertain factors. Insufficient domestic market demand, lower prices, more difficulties for business entities, and weak foundation for economic recovery. Despite the pressure and challenges, the fundamentals of China’s long-term economic improvement have not changed, and the characteristics of strong resilience, great potential and wide space are obvious. Since the economy and society have fully resumed normal operation, macroeconomic policies have made concerted efforts, and economic operation has recovered and high-quality development has steadily advanced.