上海后花园论坛,上海419论坛,爱上海龙凤419

Harbin, Heilongjiang promotes the renovation of old residential areas, investigates fire hazards and improves environmental sanitation.
Changing the old look of the block to improve the happiness of living.

Upgrade infrastructure and transform old communities; Investigate fire hazards and ensure the safety of residents; Excavating stock resources and creating creative blocks … Since the theme education was launched, Heilongjiang Province has focused on the transformation of urban infrastructure and done a good job in people’s livelihood. The reporter visited Harbin and found that with the implementation of various measures, the city’s appearance changed, living conditions improved, and people’s lives became more convenient, more comfortable and better.

Red walls, green trees, benches and windmills, in front of the 80-meter-long "graffiti" wall, people put on various poses to take pictures and punch in. Many citizens and tourists came here and praised the "net red wall" of Hongqi Street in Xiangfang District, Harbin City, Heilongjiang Province.

"In the past, this area was a garbage transfer point that stinks and residents can’t avoid." Lin Shan, head of the Pearl River Community, said. Change the way of garbage removal, demolish the damaged wall and rebuild it, and organize residents to paint the wall art. Now, this garbage spot has become a punching place.

"The wall is still that wall, but the surrounding area is clean, and the artistic taste is raised, which is different. We old residents are also happy!" Rebecca, a resident of Zhujiang Community, lamented.

Since the education on the theme of studying and implementing the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era was launched, Heilongjiang Province has carried out field research, focused on people’s livelihood, given priority to solving people’s urgent problems, and continuously improved urban functions by transforming urban infrastructure. Recently, during a visit to Harbin, the reporter learned that the local government organically combined environmental remediation with the renovation of old residential areas, investigation of fire hazards, improvement of environmental sanitation, and promotion of industrial development, constantly improving people’s happiness in living, making efforts to build a livable and happy city, and taking various measures to realize the old look of old streets with a new look.

Listen carefully to the opinions of the masses

Transform and upgrade infrastructure.

"This new cement pavement is so good that it makes people feel bright." Standing on the newly paved concrete floor in the corner of the community, Wang Guihuan, a resident of No.248 Gogol Street, Harbin, was happy in his words. In the past, the community was a mess, with abandoned boiler rooms and small yards full of garbage.

"No.248 Gogol Street was built in 1977 and is a typical old community." Chen Haijing, secretary of the Party Organization of Struggle Community, said that after the heating was connected to the grid, the community’s own boiler room was abandoned and left in the community. Now, according to the residents’ opinions, fitness equipment has been added here, and the old boiler room has been transformed into a service center for the party and the masses, providing a place for the residents’ leisure life.

There is a large stock of old residential areas in Harbin, and the area of old residential areas that were built before 2000 in Chengjiu District alone reached 61.23 million square meters. "Old residential areas have low building standards, incomplete supporting facilities, lack of property management, and strong willingness of the masses to transform." The relevant person in charge of the Harbin Housing and Construction Department said.

This year, Harbin started 224 renovation projects of old residential areas, with an area of 10.93 million square meters, 42.2 kilometers of water supply network and 100 kilometers of aging heating network, and simultaneously implemented environmental remediation work such as demolition, power repair and network cable bundling.

No.248, Gogol Street, where Wang Guihuan lives, is the beneficiary community. "The old courtyard wall has been removed, and our residents have added 400 square meters of leisure space." Wang Guihuan said.

Putting the people’s urgent difficulties and worries in the first place, Harbin strives to make the environmental remediation work in the hearts of the people, listen carefully to the opinions of the people, listen to the voices of the people, gather public opinions, solve people’s worries, and handle complaints overnight.

"I hope to solve the problems such as hanging wires in disorder and the leisure and fitness area in the courtyard of the community together in the renovation." "The roof leaks and the sewers are often blocked, and I hope it can be solved." … Harbin has deeply integrated the environmental remediation work with the renovation of old communities, and made a thorough investigation of 1,630 buildings planned to be renovated in 2023, and held more than 210 public opinion consultation meetings, renovation plan review meetings and public opinion survey forums.

Carry out hidden danger investigation actions

Ensure that residents live and work in peace and contentment.

Smooth and spacious asphalt roads, freshly painted walls, rows of lilac trees, quaint and elegant Chinese pavilions … The clean environment of the petrochemical community in Xiangfang District is refreshing.

"Demolition of private buildings in the neighborhood, cleaning up the mess, and cleaning up the environmental sanitation, the change of our community is the boss." Wang Xiuyun, a resident of the community, lamented.

Behind this is Harbin’s efforts to improve the public sanitation of the community by combining environmental remediation with striving for a civilized city: comprehensively carrying out urban road cleaning and washing, floating debris cleaning, garbage daily cleaning, and carefully carrying out greening plant pruning and maintenance.

In Ningjiang Hutong District of nangang district, the fire rescue department of Harbin took the lead in jointly launching a special campaign to investigate fire hazards, demolishing illegal buildings that affected fire safety, clearing evacuation routes and safety exits, opening fire corridors, and making full use of idle boiler rooms to build community miniature fire stations and central pump rooms.

Harbin has made great efforts to ensure the safety of owners’ lives and residences through environmental improvement. At present, all the 171 hidden fire hazards have been rectified, and 60 small fire stations and 5,493 micro fire stations have been set up.

In order to put an end to the problem of "resurgence" and all kinds of messy phenomena coming back after the renovation of old residential areas, Harbin accelerated the property management work after the renovation of old residential areas, and hundreds of property residential areas led by party building emerged in the city to play a leading role in demonstration.

The fifth block of Honghe Community in Daowai District was built in the 1990s, with more than 1,500 households. Streets, communities, property companies and community committees have set up the Party branch of Minqiang Red River Fifth Block, forming a long-term management mechanism of co-construction and co-management.

"Residents complain less and the community atmosphere is getting better and better." Meng Xuebin, director of the Industry Committee of Honghe Fifth Block, took the lead in setting up a "volunteer service team" to help solve more than 20 problems such as underground pipeline maintenance, parking space division, roof repair of residential areas, replacement of security doors, and more than 1,500 "key things" around the people, such as dredging the water, repairing unit doors, replacing voice-activated lights, and repairing stagnant roads.

Perfecting function and improving quality

Create characteristic creative blocks

"Brother, 10 more kebabs!" "Boss, another beer" … In the evening, when the lights are on, the uniform business sheds on both sides of the road come into view, and the nightlife of Xingfu Road in Xiangfang District has just started.

There is a street with a total length of nearly 1 km outside Happiness Road Food, including more than 60 restaurants, which can taste the food of most famous catering brands in Harbin.

Through the environmental improvement work, Xiangfang District upgraded this road section, expanded the sales area, opened the food and beverage stalls, made unified food stalls, set up creative landscape sketches, and created a "street with food outside".

"Opening the external pendulum can increase the turnover by at least 30%, and the government has invited enterprises to cooperate and help us build a unified external pendulum business shed for free." Yang Jing, manager of a restaurant, said.

Harbin organically combines industrial development with improving the neighborhood environment, and strives to create a unique creative neighborhood through environmental remediation. Xiangfang District has become the first area to start the pilot project.

Xiangfang District mobilizes and organizes all the towns in the whole district to dig deep into the existing resources and advantages such as regional characteristics, historical culture, realistic foundation, industrial characteristics and commercial layout, and creatively transform the old urban areas through cultural creativity empowerment.

"Environmental improvement, especially after injecting cultural and creative elements, has changed the face of the messy areas that have long plagued people and become a popular punching place." Li Yafei, secretary of Xiangfang District Party Committee, said that Xiangfang District should pay equal attention to improving its functions and improving its quality in building blocks with cultural and creative characteristics, so as to revitalize it and promote the construction and renovation of the surrounding environment.

The dormitory area of the boiler plant has been transformed into a "living room for urban culture". Leisure blocks with the theme of TCM health preservation, Dongxing Manchu-style street with strong ethnic flavor and night market full of fireworks have emerged … Since this year, Xiangfang District has successfully created 14 cultural and creative characteristic blocks, which has become a punching place to attract citizens and tourists. (Reporter Zhu Dawei, Liu Mengdan)

After basically completing the tasks of connecting "people" (social) and "content" (social media), WeChat has focused on connecting "products" (applets). Although the current mainstream product form is still App, the growth rate of WeChat applets is very eye-catching. According to QuestMobile’s report, from January 2017 to March 2018, the monthly activity scale of WeChat applets exceeded 400 million. Last month, the daily users of applets reached about 140 million, with a penetration rate of 43.9%. There is still a lot of room for improvement.

　

Then, among the three BAT companies, why only the WeChat applet has strong user traffic and ecological scene capabilities? In the WeChat ecosystem, how can small programs survive?

　

What is the difference between BAT applets?

　

In essence, applets are based on Super App, which constantly incubates countless sub-apps, making Super App a new mobile Internet infrastructure. When various needs are met by different applets, it is easy to grow an ecosystem similar to Apple App Store.

　

1. Ali applet bets on "new retail" and expands offline scenes.

　

Ma Yun once commented on WeChat. When he first came out, he was "shocked" and later felt "nothing more". In recent years, the impact of WeChat payment on Alipay in the fragmented payment scenario is obvious; Wechat applet is playing a big game of chess. Only a Pinduoduo hatched from the applet has become another trump card for Tencent’s strategic impact on Taobao’s e-commerce monopoly.

　

The incubation bases for Ali’s small programs are Alipay and Taobao. Alipay’s small programs are more tools for convenience, and they belong to the nature of "running out". A remarkable change in Taobao this year is that it is no longer a pure e-commerce platform, but a new online retail base. At present, O2O services such as "Taobao Takeaway" and "Flying Pig Travel" have been integrated in Taobao. The "Member Code" next to Taobao search box is actually a local life service business that diverts water to offline stores near users.

　

In the Taobao platform mode, in order to realize complex and non-standard service scenes, it is necessary to adopt the "applet" product form without downloading the installation package to better realize the closed loop of traffic. Because Taobao itself is the diversion base of Ali products, it has a strong technical accumulation for light applications and the product experience is not bad. However, Ali’s small program can only get through the e-commerce scene on the small program, but there is no way to enrich other formats. The profit model of Ali’s e-commerce determines that merchants still need to buy their own advertisements to buy platform traffic or rebates.

The number of local life services on Taobao homepage has increased, and the membership code is actually a store applet. At present, Alipay uses a relatively high-frequency bike-sharing applet.

　

2. The way out for Baidu applets is to advertise information flow.

　

The strength of Baidu’s link information is to link official website or webmaster. This advantage has been weakened by WeChat official account and the media in the WeChat ecosystem. Next, the trend for enterprises to do official website may be to make a small program (the cost of developing an App is relatively high). After all, in the past, there were 400 million users on the PC side, and every enterprise had official website, which is about the same as the current WeChat applet users. Therefore, it is really a bit late for Baidu to stop pushing applets.

　

The previous light Application didn’t work because Baidu didn’t have a fist-level app belt on the mobile side.In the past two years, the transformation of Baidu’s mobile terminal has been completed. In 2017, Baidu’s information flow advertising business developed at a growth rate of 20% from the previous month, keeping pace with the big search business. It is a cash flow business that Baidu has long invested in AI technology research and development. Later, in the information flow of Baidu mobile terminal, it is expected to access some small program sites with good experience, and the home page will be presented when the user pushes (recommends), without jumping to the customer’s App, and the experience is much better than the H5-style advertising landing page.

　

The author found that the "Youxin Used Car" applet was launched in the "Common Services" of Baidu App on April 12, and it has not been involved in the homepage.

　

The shortcoming of Baidu applet is that its mobile payment market share is small, and there is no way to completely open up payment scenarios in its own ecosystem; And perhaps only small program businesses that cooperate with Baidu can get the recommendation of "brand zone" and the traffic recommendation of home page, which will restrict the interest of many enterprise developers to enter.

　 　 　 Baidu applet is currently only used as a common service, and Youxin used car is used as a model to experience App, and there is no payment function for the time being.

　

How does the long tail applet survive in the "decentralized product ecology" of WeChat?

　 　

Many entrepreneurs and enterprises have been keenly aware that WeChat applet is replicating the logic of WeChat official account’s success. Few of the more than 20 million WeChat official account can really survive, and the pain points of small program operators are also closely related to the "decentralized product ecology" positioned by WeChat:

　　

The most important thing about WeChat applet service platform is not technology. The underlying technology of WeChat has been simplified. The real barrier is the accumulation of operational experience in different vertical industries, which is difficult for service providers who only do a few applet cases to cope with.The bonus of the applet is in front of us, but it is still a minority who can really play and catch it. The trial and error cost of this bonus window of about two years is high, which makes the applet service platform prone to "head-oriented" Matthew benefits.

　

Providing applet application services is a technical activity. For example, the logic of applet products in different industries, such as micro-e-commerce, smart restaurants, smart takeout, smart beauty industry, is definitely different, and the interaction of transactions in different scenarios, official website, stores or conference applets is also different.　

　

Although applets need more than 50 traffic portals, to solve the problem of difficult popularization of applets, we have to rely on the combination of "WeChat official account+Applet". WeChat official account fans have a high retention rate, but the entrance is deep, the opening rate is low, and there are many small programs with high frequency. If the users of small and medium-sized enterprises with long tail can give full play to the advantages of WeChat official account stock and small program increment, they can save a lot of promotion costs and enrich the promotion of small programs.

Zhang Xiaolong said that applets are not for e-commerce. It means that applets can be widely used in many application scenarios such as content, social interaction, stores, tools, etc. Perhaps content e-commerce, social e-commerce, fan marketing and local lifestyle services can be truly detonated through applets.

Author’s information: Reliable A Xing (Li Xing), WeChat official account: Reliable A Xing, founder of Reliable Hui, columnist of science and technology media, and personal WeChat is QQ number: 1598145405.

On the afternoon of March 5th, when General Secretary of the Supreme Leader attended the deliberation of his Jiangsu delegation at the Second Session of the 14th National People’s Congress, he proudly recounted the achievements of China’s transportation development: "Now China’s automobile production and sales volume is the largest in the world, new energy vehicles are the best, and the highway mileage is also the longest. High-speed rail has gone out, urban rail transit has also gone out, ships have also gone out, and we have also built large aircraft, which is the ‘ Three pearls ’ It’s all made … …”

Traffic is the pioneer of China’s modernization. The general secretary once compared the traffic map of the whole country to a painting, demanding that "the traffic of beautiful China be outlined more beautifully".

Under the earnest entrustment of the General Secretary, the beautiful prospect of China’s transportation power is gradually becoming a reality. Today, let’s follow "AI Pictorial" and enjoy the magnificent picture of "opening the road on every mountain and bridging the bridge when encountering water", which is full of hope, vitality and dreams.

This is the C919 plane shot on the tarmac of Shanghai Hongqiao International Airport on May 28th, 2023. On the same day, flight MU9191 of Eastern Airlines, which was carried by C919 large passenger plane, landed smoothly at Beijing Capital International Airport, marking the successful completion of the first commercial flight of this aircraft and its official entry into the civil aviation market.

Traffic is the "artery" of economic development, and the cause of traffic always has a heavy weight in the heart of the supreme leader General Secretary.

In Xiangxi, Hunan Province, the General Secretary specially visited Aizhai Extra-large Suspension Bridge and asked carefully how the bridge was operating and whether the lives of local people had improved.

At the Tianjin Port Terminal, the General Secretary is very concerned about how to make the port bigger and stronger, pointing out that "the economy needs to develop, the country needs to be strong, and transportation, especially shipping, needs to be strengthened first";

At Beijing Daxing International Airport, the General Secretary carefully examined the process of intelligent technology and full self-help paperless intelligent check-in, and pointed out that Daxing International Airport should be built into a "world-class aviation hub" to show the wisdom and strength of the people of China to the world;

… … … …

A bridge spans north and south, all the way to all directions. Floating China, generate has developed vigorously in the construction of a powerful transportation country.

Up to now, the total mileage of China’s comprehensive transportation network has exceeded 6 million kilometers. From Linhai Xueyuan to Jiangnan water town, from Saibei Gobi to Lingnan mountains and rivers, 159,000 kilometers of railway networks crisscross, and 45,000 kilometers of high-speed rail lines are interwoven into a network. In 2023, China completed 61.25 billion person-times of cross-regional personnel mobility, up 30.9% year-on-year. The "travel radius" of Chinese is getting longer and longer, and the good life is constantly extending.

Behind the remarkable achievements, it is inseparable from the support of science and technology. When attending the deliberation of the Jiangsu delegation, the general secretary pointed out that it is necessary to "take scientific and technological innovation as the guide, make overall plans to promote the upgrading of traditional industries, the growth of emerging industries, the cultivation of future industries, and strengthen the deep integration of scientific and technological innovation and industrial innovation."

In recent years, China’s transportation science and technology innovation has achieved a historic breakthrough from quantitative accumulation to qualitative leap, from local advanced to system capacity improvement.

In Fuxing series EMUs, China has completely independent intellectual property rights for all key system software, and the China standard used accounts for 84%; During the construction of Daxing Airport Station, the builders installed 1232 shock-absorbing pads under the terminal building of Daxing Airport to minimize the vibration caused by trains passing through underground tunnels at high speed. Intelligent high-speed rail, intelligent highway, intelligent port, intelligent shipping, and intelligent postal service have accelerated to take shape, criss-crossing China … … Transportation has a stronger "science and technology flavor" and the level of modernization has been greatly improved.

When the road is clear, everything will flourish. The road network is criss-crossed, the routes reach the whole world, and the ocean-going ships shuttle back and forth, which drives the integration and development of industry, tourism and culture, and effectively unblocks the domestic and international double cycle. China high-speed rail, China Road, China Bridge and China Port, which are going global, intersect with the world and communicate with the times, and promote China’s deeper integration into the global industrial chain supply chain system.

In January 2023, the most "frost-resistant" and intelligent member of Fuxing family — — Fuxing alpine intelligent EMU is speeding on the land of Northeast China.

"The transportation industry is moving forward step by step, ahead of the world, and craftsmen are very important in it. It is not enough to design the light drawings well, and finally it will be implemented in the hands of welders. ‘ Without Jin Gangzuan, we can’t do porcelain work ’ 。” When participating in the deliberation of the Jiangsu delegation, the general secretary was concerned with transportation talents.

As a "craftsman" from the front line, representative Sun Jingnan shared her thoughts at the meeting: "What is ‘ Craftsman ’ ? Is to treat yourself in the professional field ‘ Haggle over every ounce ’ After tempering, breakthroughs can be achieved. "

With the rapid development of transportation industry, the demand for high-quality talents is also more vigorous. In recent years, Sun Jingnan has never kept secrets with his apprentices, and led the team to complete one technical research and achievement transformation after another. In the future, Sun Jingnan plans to work with more skilled craftsmen to manufacture high-end, intelligent and green rail transit vehicle products with exquisite skills and welding guns in his hands.

If you do not stop, the future can be expected. Nowadays, a mobile China is marching steadily towards the vision of "people like their actions and things are superior to their flow". The dense modern three-dimensional transportation network has made people’s "happiness road" smoother and smoother, and also provided solid support for Chinese modernization.

Text | Ten o’clock movie original

You won’t believe it.

Spongebob, which seems young, is actually an adult animation.　

Here, the crab boss will also encounter a midlife crisis.

For the purpose of protecting children, Nick Children’s Channel has removed the episode and other sensitive content.　

However, after revisiting this animated work many times, Lao Mei Er found that its audience is not just children.

The underwater group portrait that people talk about is completely a movie.Illustration of contemporary young people’s survival.

Won the 374th outstanding employee of the month, and then what?　

Spongebob’s name was a misunderstanding from the beginning.

He is actually a post-80s migrant worker named Bob, whose daily job is to be a senior chef in krusty krab restaurant.

　

This title sounds great, but it’s actually nothing.

Because, the crab boss always excuses to delay the salary, and the salary is always lower than the legal minimum.　

As a colleague of Spongebob, Squidward Tentacles has already seen through everything, and he just does his job inefficiently every day.　

But Spongebob is not, always rushing to the forefront like chicken blood, insisting on fighting for the cause that you love for life.

You know, capitalists love this kind of dreamer who is indifferent to fame and fortune.　

Crab boss bought a pair of leather boots for his daughter Pearl Krabs, but he didn’t want to smash them in his hand … It’s easy.　

He turned his head and made up a gimmick that "only the best hamburger chefs in the world are allowed to wear it" to cheat Spongebob out of his salary.　

As a boss, the skill of drawing cakes is not limited to this.He also named Spongebob as the outstanding employee of the month for 374 consecutive years.

As the backbone of several honors, Spongebob is naturally the best choice for the branch manager.　

So, he sat neatly under the stage, his eyes shining, and he was even ready to give a thank-you speech, just waiting for the crab boss to read his name.　

But in the end, it was Squidward Tentacles who got the promotion.　

Why?　

Crab boss said, because Squidward Tentacles is more mature.

On the endless bikini beach, Spongebob’s energetic appearance is a bit out of place.　

So, when Squidward Tentacles accidentally accused him of being a freak, Spongebob decided to be a normal person.　

After trying again and again, he gradually lost his pores, freckles and edges, and replaced them with smooth and smooth.

He wants to change back.　

Spongebob shouldn’t be a nondescript product on the boring life assembly line.　

In order to help him regain himself, he sent a big star to accompany him to do all kinds of unique behaviors.　

When they accidentally fell into the water, the passing fish saw this scene and asked curiously, "Mom, what animal is that?"　

Little fish mother answered:"Those are rubbish, baby, they are not normal people."　

Philosopher: Genius sends big stars? Idiot Patrick?　

When it comes to Patrick, people will think of his friendship with Spongebob for the first time.

You all know the story of catching jellyfish, right?　

Da Xing invited Spongebob to catch jellyfish, but Spongebob refused on the grounds of going to school.　

Spongebob asked, "What do you do when I’m not at home?"　

Patrick replied, "When you come back."

Once, Spongebob and the rascal traveled to the future in a time machine.　

Bikini beach has already turned into a long yellow sand after the famine in Crab Castle.

All the sea creatures are gone.

Only Patrick suddenly poked his head out and told Spongebob in surprise:

"They all gave up on you, but I didn’t, because I’m not very smart."

Pai Daxing is clumsy and often goes wrong, but in an experience of gaining wisdom coral brain, his IQ soared rapidly and he refused to catch jellyfish with Spongebob.

He was not happy after he successfully entered the field of science.　

In order to get back Spongebob, Patrick decided to switch back to his brain and said, "Knowledge can’t replace friendship. I’d rather be an idiot than lose you."

But is Patrick really an idiot?　

When Spongebob is frustrated by his friend’s snobbery, he will make a pertinent statement: "When it comes to money, no one is right or wrong. The key point is whether there is friendship or morality."

He will suddenly go to the restaurant next door to his house for a night, just because "sometimes I want to run away from everything."　

When Squidward Tentacles asked him why he had to bring two boxes of stones to stay in the hotel, he responded confidently: "How do I live is none of your business!"　

He even saw through the social reality: "Life is unfair, get used to it!" "

　
Pai Daxing is a man who is as wise as a fool, and his philosophy of life, which he inadvertently reveals, often leads to a solution for those who are fascinated by the authorities.　

However, detached from things, he will inevitably encounter lonely moments.　

When he saw Spongebob leading Gary the Snail to a pet competition, Patrick suddenly lost control and roared:

"You don’t understand! Spongebob, you never know how lonely it is to be alone behind the blockade … "　

As a migrant worker, Squidward Tentacles is the opposite of Spongebob.

Spongebob always has no feelings, but Squidward Tentacles can see through the nature of capitalists.　

What should we do?

Uprising: breaking the window of the slave kingdom of the crab boss!

Standing on the bikini beach, he loudly complained about the bad behavior of the crab boss, which attracted the support of the passing underwater creatures.　

But, listen to what they are saying-　

Fish A: "I’m hungry after supporting him for a long time."　

Fish B: "Hey, let’s go to krusty krab now."　

Set the underwater creatures, trampling on Squidward Tentacles’s body, and heading for the restaurant.　

Squidward Tentacles lying on the ground was completely doused with enthusiasm, and then murmured:

"No one really cares about the fate of employees. All they really care about is their own happiness."

The cashier’s work day after day kept killing his fighting spirit.

But passion will come back one day: "If one day I really realize my dream, I will never let my feet stand on this greasy floor!" "　

The job is boring and has no future, and the boss is very stingy.　

Therefore, Squidward Tentacles resigned indignantly after being misunderstood by the crab boss that he was an inside job thief, and firmly believed that there was much to be done in the future.　

But in the next scene, he is begging on the roadside in rags, and sees the reality clearly in his life of hitting the wall several times: "I am a loser!" "

Without the means to make a living, homeless.　

Even the dream about artists that has always fascinated him has been ruthlessly killed by life.　

Crab boss had accidentally bumped into Squidward Tentacles in the cemetery.　

When he approached, he found that there was only one sentence on the tombstone:Buried here are Squidward Tentacles’s hopes and dreams.

Alien: There is a Texas squirrel at the bottom of the sea.　

In the vast underwater world, there lives a squirrel from Texas, Sandy.

She is not only good at catching jellyfish like Spongebob and Patrick.

But as a scientist, explorer and inventor, he is good at karate, weightlifting and rodeo, and often wins the first prize in various competitions.　

She’s not like Squidward Tentacles, who is both bereaved and fearful.

Instead, I live a positive life and successfully broaden my circle of friends with excellent social skills.

Sandy is more powerful than all marine animals, but she is the only land creature that appears at the bottom of the sea.　

The alien spacesuit and helmet are destined to make her an underwater alien.　

Once, marine creatures gathered together and laughed at her for not being able to survive here without external assistance.　

After hearing this, she flew into a rage and immediately tore the spacesuit and broke her helmet, trying to blow the arrogance of the other side.

But being as good as Sandy can’t change the physical differences and the geographical disparity.　

She is a Texas squirrel wandering on bikini beach, wandering at the bottom of the sea.

Sandy, who is homesick, occasionally hears a sentence that has nothing to do with her and will instantly break through the defense:

"Fly, little jellyfish, fly back to your own home. You don’t belong to this deep seabed. Go find your friends and family. I know you all miss each other deeply."

Maybe it’s time to leave. Sandy dried her tears and said, "It’s time for the wanderer to go home."　

The pictures in this article are from the Internet. If there is any infringement, please contact and delete.　

coda

This animated work has been released for thirteen seasons in succession.

The seasonal douban score is 9.4+, and the highest score is 9.6.

Even in the off-duty days, people often dig out the details.　

However, this realistic story is still underestimated.　

Because-　

It is not serious, and it often completes the process of self-mockery and introspection in an easy way.　

It doesn’t preach, but it can’t wait to pierce the window paper that stands in front of the truth of life.　

It found us in adjacent dilemmas.

　　The supermarket paper towel wedding dress, known as the "masterpiece of supermarket aunt", became a hot spot for forwarding and commenting as soon as it appeared in Weibo. As a result, various creative displays against the sky, such as toothpaste bicycles, towel tropical fish and mat armor soldiers, began to appear frequently … The reporter visited Changsha supermarket and learned more detailed stories behind these amazing "masterpieces". Network observer (reporter) Li Jin

　　Recently, some creative supermarket product display photos have been circulated wildly on the Internet, among which Weibo, the model of tissue wedding dress, has the largest forwarding volume. Because many supermarket waiters are already aunts, these creative displays have also been praised as naughty "supermarket aunts" by netizens. "I just went to the supermarket and met a sexy beauty. I found that supermarket aunts are all talents, and I admire them. I specially photographed them to share with you! " Some netizens commented on Weibo.

　　@ News Background: Supermarket aunt works against the sky

　　Recently, Changsha netizens have also found mop lucky plates, mahjong mat armor and cute fruits in the supermarket … Mr. Li, a citizen, went to the second floor of Wonderful Life Supermarket to buy fruits. As soon as he entered, he was attracted by a huge "bicycle" on the promotion shelf. Looking intently, it was actually made of hundreds of toothpastes!

　　"How creative!" Mr. Li, who originally only needed to buy fruit, was surprised and bought toothpaste when he saw that the price was very cost-effective.

　　In supermarkets such as Carrefour, there are beautiful wedding dresses made of toilet paper: a tube of toilet paper is wrapped around the model statue, connected from the waist, dragged to the ground, and fixed with paper clips to form an elegant "toilet paper wedding dress"; There are "tropical fish with towels": towels are rolled into rolls, with green and blue towels as the bottom, pink towels as the outline, and a vivid "tropical fish" seems to be swimming … There are also cute cartoon characters piled up with dishwashing cloths, huge "cattail leaf fans" made of mops, handsome "armored soldiers" made of sleeping mats, "Totoro honey pomelo" and other series of works.

　　However, is it really that supermarket aunts are bored and POSE with all kinds of goods? If you think so, you are really "naive". The reporter learned that in fact, this is a "promotional artifact" carefully developed by marketers, and the technical term of anti-God is "creative display".

　　@ 丫丫丫丫丫丫: Behind the supermarket aunt is a marketer.

　　Who came up with these ideas? Is it really a supermarket "aunt" who is idle to kill time?

　　The reporter visited a large supermarket in Changsha and learned that in fact, there are not only supermarket aunts with specific arrangements behind the masterpiece, but more importantly, a group of creative professional marketers.

　　The staff of Carrefour supermarket told the reporter: "This is not the masterpiece of’ Aunt’, but mainly planned by professionals from businesses and supermarkets. Generally, it is only available when manufacturers promote their products. "

　　The reporter learned from several supermarkets that these ideas generally originated from the planning department of suppliers.

　　After they make creative planning, it is time for the supermarket "aunt" to show her talents. "After the supplier designs the shapes and props, he will send someone to the supermarket to lead the waiter to be responsible for splicing the goods." Only in this way can we see those "works of God".

　　In addition, many supermarkets also have their own planning departments and art departments. In order to improve the popularity of supermarkets, they will also make some planning plans for the display of goods.

　　@ 中中中中: Attracting customers and improving sales performance.

　　Why do manufacturers and supermarkets make masterpieces? In fact, the goal of "making you look good" is to "make you pay" and attract consumers and improve sales performance by "aunt’s masterpiece".

　　Just like Li Mian, I just went to the supermarket to buy paper, but I was attracted by the idea of "bicycle" toothpaste. When I saw that it was quite affordable, I bought an extra toothpaste. Many citizens are naturally attracted when they see the creative display in the supermarket. Take a closer look at how it is put out under research, so as to pay more attention to the product.

　　"Ordinary goods display is difficult to attract customers’ attention." Ms. Li, a staff member of Carrefour, said that this kind of creative display can especially attract customers to stop and watch.

　　In addition to the need for creative display for manufacturers’ promotion, supermarkets will also use this creative display to create a festive atmosphere and gather popularity when holidays come. While adding vitality to the supermarket, it can also make customers happy.

　　(Original title: Supermarket Auntie’s creative drink bottles are arranged into a stadium (Figure))

(Source: Red Net)

A few days ago, Harbin actor Adi went on a hot search! Everyone was gripped by a smile from her.

In the TV series "Boiling Life" hit by Jiangsu Satellite TV, Adi turned into Shen Xia, a "female autobot", and partnered with Elvis Han, a native of Harbin, to reproduce the development of China’s automobile industry and write boiling life with youth and blood.

The 1980s was a sentimental era. Many young intellectuals devoted themselves to modernization, and that generation was pure, romantic and passionate. Shen Xia was a rare graduate of a prestigious university at that time. Before Adi started shooting, he asked his parents about many stories of that era, looked at a lot of old photos and got a deep understanding of the mental outlook of college students.

Homework was not done in vain. As soon as "Boiling Life" was broadcast, the topic # Adi’s youthful atmosphere in the 1980s # was posted on Weibo Hot Search. In the play, Adi’s simple coat was paired with a plaid shirt, and a neat ponytail was tied up, full of vitality, and he laughed green and simple. The netizen said, "The atmosphere in the 1980s was severely grasped."

This is Adi’s first time as an automobile engineer. She said: "Shen Xia has the ideal of serving the country with technology and the spiritual belief of fighting for it all her life, which is what attracts me most. This spirit has always infected me during filming."

One is a "precious" college student in the factory, and the other is a test driver who often gets into trouble. Although Adi and Elvis Han played Ai Changan as childhood friends, they started out as a pair of tell it to the judge, and they finally showed their hearts to each other, but they were suddenly changed. Because of Ai Chang ‘an’s impulse, Shen Xia’s father died with injustice. On the one hand, it is a father who is as grateful as a mountain, and on the other hand, it is ocean deep’s lover. In the play, Shen Xia is in a dilemma …

Adi commented on Elvis Han, "He is a very good partner, very dedicated, and has a very accurate understanding and interpretation of the role. When filming, everyone gets along very well." Although it was the first time for the two Harbin actors to be partners, they got full marks in tacit understanding and played the role of "Chinese Auto Man" together. They seemed to have witnessed the progress of China automobile industry from "Made in China" to "Made in China" and then to "Created in China".

Standing next to a heavy truck, Adi looks particularly petite, but she is a real "racing driver". In April, 2020, she set up a motorcade, which she thought was "the most successful thing she had done since she was 30".

She was very excited to appear in the first TV series in China with the heavy truck industry as the background. Adi, a "car fan", was very happy when she saw the seven-ton truck of Huaqi 2190 in the drama. "I like every model in the drama very much, and they are the testimony of the struggle of’ Huaqi people’ for the automobile industry."

In the heavy truck manufacturing industry, the vast majority of employees are men, but Adi plays Shen Xia, who is a female automobile engineer, showing gentle and strong "her" strength. "Many’ female autobots’ gave up their comfortable and comfortable lives and devoted themselves to construction without hesitation. They showed great professionalism and admiration in their work." Adi said.

Harbin Daily reporter Gao Yun

、

　　　　 China’s current consumer rights protection system is mainly the People’s Republic of China (PRC) Product Quality Law, the Consumer Rights Protection Law, the civil compensation system in the civil law and the product "three guarantees" system implemented by administrative means in 1988.

Although the above-mentioned laws and regulations in China provide consumers with weapons to protect their rights, the contents related to the recall of defective products are general, too general and lack of operability. For example, Article 26 of People’s Republic of China (PRC) Product Quality Law clearly stipulates: "Producers should be responsible for the quality of their products." Article 18 of the Law of People’s Republic of China (PRC) on the Protection of Consumers’ Rights and Interests clearly stipulates: "If an operator finds that the goods or services provided by him are seriously defective, even if the goods or services are used correctly, it may still cause harm to personal and property safety, he shall immediately report to the relevant administrative department and inform the consumers, and take measures to prevent the harm."

Although these laws and regulations in China are the same as the product recall system to protect consumers’ personal and property interests, there are obvious differences between them. According to China’s current laws and regulations, a product will only be treated after it has caused harm. At present, the domestic treatment of defective products, such as quality problems or unqualified products, mainly adopts that the damaged consumers claim compensation from the sellers or manufacturers through judicial procedures on the grounds of breach of contract or infringement. For defective products in mass production, a large number of consumers’ personal and property are damaged.How the administrative organs manage and punish, and promote enterprises to improve and make up for product defects is still weak. After the implementation of the defective product recall system, as long as a batch of products are found to have quality problems and may cause harm to consumers, enterprises are obliged to recall or destroy the products. Obviously, the product recall system has the function of "nip in the bud", which has obvious advantages compared with the passive protection of the Consumer Protection Law.

Ready Player One

Special feature of 1905 film network After four days of release, the box office was 450 million, and the Douban score soared to 9.1.

Completely fired!

This film is adapted from the novel of the same name by the otaku Ernst Klein, and there are hundreds of game movies.

I really can’t think of a more suitable candidate than Spielberg to turn such a book into a blockbuster.

Cover of Ready Player One’s original novels in English and Chinese

Ready Player One is indeed a bestseller and has been translated into 20 languages. However, it caters to some people’s feelings, and at the same time, it is also considered by some readers as "otaku’s cool writing".

Among readers all over the world, some people dislike this book, and some people call it "Wikipedia about the 1980s" — — That is, those eggs are useless for narrative, and the only value is to let readers pat their thighs: ah, I know this!

At that time, Xiao Dianjun was made to want to throw a book by its narrative way of constantly throwing stalks.

The original author was called "the sexiest geek on the planet today" by USA-Today.

But when Spielberg first read this book, he was shocked by the author’s foresight for the future through these stalks. In order to make more people accept it, he injected what he was good at into this "history of popular culture in the 1980 s": longing for the future and trembling; Passion for creativity; There is even an inner observation of a lonely and talented boy.

When it was released in the past, the audience queuing to buy tickets filled several streets, and some people watched it several times.

They all want to immerse themselves in such a scene again:

In john williams’s soundtrack, pterosaurs flew across the sky, and giant Tyrannosaurus rex leisurely crossed the grassland. For the first time, people and ancient creatures hundreds of millions of years ago were separated by only one screen, and their hearts must be filled with awe.

After more than 20 years, we are lucky enough to look at a half-gorgeous and half-barren future through a screen, and we are as excited as those people in those years.

These dreamlike experiences are all attributed to Spielberg. A 72-year-old man, a big child.

As a famous director who has filmed the seventh sci-fi film, five of which have become classics in film history, Spielberg’s talent and imagination are well known. However, few people may notice that after close encounters of the third kind, he stopped writing his own plays, but explored and visualized the works of first-class best-selling novelists.

For example, Melissa Mathison, a female screenwriter, was hired for E.T. Alien, and the inspiration came from Kubrick, who wanted to adapt this short story herself.

Stills of E.T. Alien

Today, Xiao Dianjun wants to talk to you about two other classics — — Jurassic Park and, like Ready Player One, they are adapted from famous science fiction.

As one of the greatest directors of commercial films in Hollywood, Spielberg did this … …

　

Jurassic park

Come on, try Spielberg icing?

Jurassic Park is the first sci-fi film adapted by Spielberg, which comes from michael crichton’s novel of the same name.

　

It created a box office miracle.

After the film was released, it won 900 million dollars at the box office and became the highest-grossing film in history at that time. At that time, there was a crazy dinosaur craze, which inspired a lot of movies featuring dinosaurs and monsters, such as Godzilla in Japan.

　

A movie can sell well in a short time, perhaps just because of IP or dazzling special effects technology. But to become a classic, a solid script has become the top priority.

　

Michael crichton, the author of the original novel, is outstanding in his professional level. The man with a bright resume transferred from Harvard Literature Department to Anthropology Department, and also got a doctor of medicine from Harvard. It is precisely because of this hard-core knowledge of anthropology and medicine that his sci-fi thrillers are horrified … … Especially cultured.

　

Michael crichton, the author of the original novel

The most important genetic engineering technology in Jurassic Park was studied in 1970s. In 1984, scientists cloned gene fragments from the fur of spotted donkey 140 years ago, which proved that DNA can be replicated in inanimate biological tissues. Michael has been paying attention to this field. It took him seven years to publish Jurassic Park in 1990.

After the film was made, someone specially asked Paul Barrett, a dinosaur researcher at the British Museum of Natural History, if the film was all nonsense. The researcher replied: "Many scientific theories in the film are actually reasonable. Even the use of frogs makes sense, because they are quite commonly used laboratory animals in this field, and we know their gene sequences very well. Therefore, Jurassic Park was very avant-garde at that time. "

If such a novel is made into a movie, it must be changed greatly. Coincidentally, it met Spielberg — — Hollywood is the director who will sugar-coat all kinds of hard goods to satisfy the curiosity and security of most audiences.

　

What does Spielberg do?

　

His first step is to make the grandma selling tea eggs on the street understand the original professional and obscure words in the book.

　

For example, there is a classic "dinosaur DNA recovery animation" in the movie. What is said in the book is particularly complicated, but it is shown in a way similar to flash in the movie.

Animation explanation version of DNA restoration

　

Secondly, he will use the most advanced technology to revive the dinosaurs he was obsessed with since childhood, and then Amway will give them to audiences who have never been interested in them.

　

Spielberg once said in an interview: "When I was young, I even dreamed of dinosaurs. Therefore, when filming Jurassic Park, I thought more about my childhood memories and fantasies than the original novel. "

　

His favorite is Triceratops. When he saw Triceratops in a museum when he was a child, he sympathized with it. He once fantasized about what happened to it before it became extinct. So he deliberately set up a sick triceratops when he was filming.

He found the most advanced industrial light and magic studio at that time to build dinosaurs with computer special effects, and a small part of them spent huge sums of money to make models. Among them, the mechanical Tyrannosaurus Rex props weigh 12,000 pounds (about 5.4 tons), which can really crush people to pieces when started.

　

Designers also draw materials from various animals for the movement patterns of dinosaurs. For example, the brachiosaurus, the first appearance in Jurassic Park, is the first creature made entirely by computer special effects in the history of cinema. Its action of lifting its legs off the ground and roaring to the sky is taken from an elephant.

Brachiosaurus was taken from elephants.

　

The last layer of icing, which is also the thickest layer, is on the theme and narrative mode of the novel.

　

As many movie fans know, all the series of Jurassic Park add up, and only one tenth of the content of the novel is selected for adaptation.

　

In addition to too much professional knowledge, the original novel is also a dark, pessimistic and cruel world, full of all kinds of bloody and dark fragments as bad as Alien. In particular, the author’s attitude is calm and merciless. He thinks that there is no essential difference between natural creation of human beings and natural creation of dinosaurs. On the contrary, people make their own decisions to become creators, and the consequences they bring must be borne by themselves.

　

Just like the following fragment in the original work, if it is put on the big screen, it is estimated that many parents will stop their children from entering the cinema.

　

“Elena opened the door. The baby is lying in the cradle of wicker, wrapped in a light blanket, and only his little face is exposed. There are three dark black lizards squatting on the edge of the cradle, just like three grotesque statues. When they saw Elena, they looked up at her curiously, but they didn’t run away. In the light of the flashlight, Elena saw blood dripping from their mouths. A lizard barked softly, lowered its head, shook it quickly and tore a piece of meat from the baby’s face. Elena screamed and rushed forward, and the lizards flew into the darkness. However, as early as when she walked to the front of the cradle, she had already seen what the baby’s face looked like. She knew that the child must have died. "

　

Spielberg added a soft lens to the story. A lot of discussion in this part is omitted, and the main line of the film is taken as the story of the ultimate victory of the great escape of mankind, which promotes the brilliance of human nature. After letting the audience experience the thrill, they breathed a sigh of relief in happy ending.

　

In this way, the whole film is no longer sharp, but has played a psychological soothing role for the American audience at that time.

Minority report

Fans will be disappointed, but I am concerned about the future within reach.

If we say Jurassic Park, Spielberg is wrapping a dark kernel with syrup; Then, for Minority Report, what he did was to pick up a knife and carve the original mysterious shape into an angular shape.

　

After the release of Minority Report, its income was 350 million dollars, which was three times its cost. In the Hollywood Reporter’s best list of films starring Tom Cruise in 2016, the first place was Minority Report.

In fact, if Tom Cruise hadn’t recommended it, Spielberg probably wouldn’t have touched the novel at all. When he made this film, he once said: Philip Dick’s novels are not suitable for most movies, and I’m sure die-hard fans will be disappointed with the movies.

　

If michael crichton, the author of Jurassic Park, is an elite science fiction writer, then Philip Dick is a real diaosi geek. He dropped out of primary school, dropped out of secondary school, and was often in financial distress when he grew up. Writing science fiction became a pillar of his life. He started writing at the age of 27 and died at the age of 53. He published 44 novels and 121 short stories in his life.

Philip dick

　

His novels have a unique temperament and a surprisingly wide range of concerns. Unfortunately, when he was alive, most of his novels were published in some cheap science fiction magazines, and he was poor until he was old, even eating dog food for a time; After his death, he was gradually recognized and became the first science fiction writer recognized by the history of American literature. Blade runner, Total Memory, and the previous TV series Electronic Dream: Philip Dick’s World are all adapted from his novels.

　

Minority Report is one of his short stories, which is extremely short and the theme is very obscure. I guess Spielberg had a big head when he got it.

　

So, how to change it?

　

First, add a 50% murder case first!

　

Spielberg once said, "The success of this film depends on the characters 50% and the mysterious murders 50%."

There are only two murders in the novel Minority Report, but there are five murders in the film.

Although the protagonist in the novel is also a captain, he is an old man in his fifties who worries that his young subordinates will rob him of his seat every day. Tom Cruise, the captain of the film, is handsome and strong, with thick hair and bad habits such as taking drugs.

In order to enrich the plot, besides murder, Spielberg also added many action elements.

For example, fighting

Kidnap (a prophet)

The protagonist in the novel has only one core contradiction in the plot, that is, finding a way out, and has no previous history. However, in the movie, the director added a very deadly pre-historical trauma to the protagonist — — His five-year-old son was abducted by a swimming pool and has been missing ever since.

On the one hand, this design is to add key plots; On the other hand, it also aroused the audience’s sympathy for the protagonist who had been traumatized, and better integrated into this plot that was too cold.

　Tom hanks looked at his son’s holographic projection.

　

Second, carefully build a future world

　

Philip Dick’s sci-fi novels are not only full of brains, but also famous for their imprecise techniques, which may be attributed to his extensive interests, but he has never systematically studied science and technology.

For example, some people laughed at him for still using the old TV set … …

Spielberg-style science fiction films, in addition to the complexity of the plot, must also have technology linked to the most cutting-edge technology at present. He is crazy about creating the "future", and he does not hesitate to make great efforts for it.

　

Starting with E.T. Alien, his way is not only to rely on imagination, but also to find experts to dig into details.

Three years after the film started shooting, he found 15 experts in different fields, including architects, novelists, computer engineers, biological scientists, MIT dean and so on, and brainstormed in a hotel for three days.

He wants these people to give him some advice on how to make a future world that is both convincing and different from ordinary science fiction movies. In three days, they actually worked out an 80-page plan, from architecture to technology.

　

Some inventions they came up with in 1999 have actually come true in today’s world.

　

Such as 3D screen, such as iris recognition authentication.

　

Spielberg described his imaginary future world like this: "The Internet is watching us, and the TV is watching us. We lost our privacy. An advertisement will suddenly appear in front of us and talk to us. "

　

Compared with the pessimism in Philip Dick’s novels, Spielberg is an optimist. He is always full of enthusiasm for new technologies that may come. When talking about this film, he once said: "I hope all the small technologies in the film will come true. We will have pollution-free transportation and newspapers that are automatically updated. "

Third, empathize with the audience, not scare them away.

　

The inspiration of Minority Report comes from Philip Dick’s own anxiety about the Cold War. In the struggle between the two great powers in the book, it is like a miracle that a little person wants to find a way out and survive. The whole novel is like a gloomy joke.

In the movie, the core of this story is replaced by the mainstream values of Hollywood, and it becomes a survival story that people should not lose hope under any circumstances and should fight against fate.

Some scary details in the novel have also been changed to more acceptable settings.

　

For example, in the novel, those prophets are actually mentally retarded and squeezed by the government without human rights. But in the movie, it was changed to a normal person, named after several crime novelists. Agatha, led by Agatha, guided Tom Cruise out of danger again and again with the image of "Goddess".

Changed mental retardation into a goddess

　

These changes have undoubtedly reduced the lingering pessimistic background and self-torture in Dick’s novels, and replaced them with Spielberg’s value that "human nature will always find a way out". If reading the original novel is like witnessing the fate of mankind being hung in the air, Spielberg will finally make everyone who watches it land on his feet and be satisfied.

Over the years, all the children who were shocked by such a big film have grown into middle-aged people, and it seems that Spielberg is the only one who hasn’t changed.

In last year’s documentary Spielberg, Xiao Li commented on Spielberg when he was young:

The child in the Arizona desert kept watching TV and movies, and one day slipped into the film company and found his destiny there. This is a touching Hollywood story in itself.

And Daniel Day Lewis said he was old:

We all have a shelf life, and it slipped away without our knowledge. But this may not be the case for Spielberg. He will love his job until he dies.

　

At least from Ready Player One’s point of view, they are all right.

Original transfer network transformation medical network

[Introduction] Cancer-associated fibroblasts (CAFs) are the key components of tumor microenvironment (TME) and play an important role in regulating cancer progression. However, the underlying mechanism of CAFs activation is still unclear.

On April 8, researchers from the Medical College of Kunming University of Science and Technology published a research paper in the journal Cell Death Discovery, entitled "CXC L12 Alone is enough to reprogram normal fibers into cancer-associated fibers". In this study, the researchers found that cancer-associated fibroblasts (CAFs) significantly induced normal fibroblasts (NFs) to acquire the characteristics of CAFs (called CAFs-like fibroblasts, referred to as CEFs for short), including up-regulating α-SMA and vimentin, enhancing the ability of proliferation and migration, and improving the ability of promoting the migration of lung cancer cells. In vivo, CEFs accelerated the growth of A549 xenograft and induced spontaneous lung metastasis. In particular, inhibition of CXCL12 signaling pathway and STAT3 pathway can reduce the transformation from NFs to CAFs, thus inhibiting the progress of lung cancer in vitro and in vivo. This study revealed that CAFs can promote the transformation of NFs into CAFs-like cells through CXCL12/STAT3 axis, and enhance the growth and metastasis of lung cancer. Therefore, inhibiting CXCL12/STAT3 axis is a promising strategy for the treatment of lung cancer and other CXCL12-dependent malignant tumors.

https://www.nature.com/articles/s41420-025-02420-0#Abs1

Research background

01

Cancer-associated fibroblasts (CAFs) are the main components of tumor microenvironment (TME), which promote tumor proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) and drug resistance by secreting growth factors, cytokines and extracellular vesicles, thus promoting tumor development. CAFs is a large number of fibroblasts with α -smooth muscle actin (α-SMA) positive and activated myofibroblast phenotype. Different from normal fibroblasts (NFs), CAFs has stronger abilities of proliferation, migration and contraction. It is generally believed that CAFs mainly comes from NFs where organizations reside, but the mechanism of transforming NFs into CAFs is still controversial.

More and more evidences show that cancer-associated fibroblasts (CAFs) can be activated by signals from tumor cells and matrix environment, which provides a unique insight into the complex interaction in tumor ecosystem. Researchers found that the hardness of extracellular matrix (ECM) can induce mesenchymal stem cells (MSCs) to differentiate into CAFs, thus promoting the invasion and metastasis of triple negative breast cancer (TNBC). In addition, in gastric cancer, CAFs can also "educate" NFs to promote cancer cell proliferation and T cell inhibition. However, the exact mechanism that drives CAFs activation is still largely unknown. Therefore, detailed research is needed to clarify the molecular mechanism of cancer-related fibroblast activation, so as to open up a new anti-matrix therapy approach.

CAFs promotes the transformation from NFs to CAFs in lung cancer.

02

In order to explore the clinical effect of tumor-associated fibroblasts (CAFs) in the process of transforming normal fibroblasts (NFs) into CAFs in lung cancer, the researchers isolated pairs of CAFs and NFs from tumor tissues or corresponding non-malignant tissues adjacent to tumors of several lung cancer patients. CAFs specifically shows highly expressed vimentin and FAP (known CAFs markers), and its ability to promote the migration of lung cancer cells is stronger than that of NFs from adjacent tissues. Then, NFs was treated with CAFs conditioned medium (CM), and then the characteristics of CAFs were analyzed. The levels of CAF markers α-SMA and vimentin expressed in NFs after CAFs CM education increased significantly. These results indicate that CAFs may be helpful to endow NFs CAFs with specific characteristics.

CAFs induces NFs to acquire CAFs characteristics in lung cancer

conclusion

03

To sum up, this study expounds a new molecular mechanism that the interaction between NFs and CAFs promotes the metastasis of cancer cells. CXCL12/ STAT3 pathway is a key participant in NFs-to-CAFs transition, which provides a key therapeutic target for developing new cancer treatment methods.

References:

https://www.nature.com/articles/s41420-025-02420-0#Abs1

Original title: "New Molecular Mechanism! Kungong medical college: an important therapeutic target of new cancer treatment strategy

Read the original text

　　Cctv newsOn December 5, the National Health and Wellness Commission held a press conference to introduce the measures to deepen the implementation of grassroots health care and convenience services. Zhu Hongming, deputy director of the Grassroots Department of the National Health and Wellness Commission and a first-class inspector, said at the meeting that since the deepening of medical reform in 2009, National Health Commission has continuously promoted the equalization of basic public health services, and grassroots medical and health institutions have undertaken a large number of basic public health services, especially the health management of patients with chronic diseases, and have established relatively stable contacts with urban and rural residents. Many urban and rural residents have already felt this service. In promoting the management of chronic diseases, there are mainly the following measures:

　　First, in the grassroots convenience measures, we will promote the full implementation of long-term prescription services for chronic diseases such as hypertension and diabetes in community health service centers and township hospitals, and gradually expand the coverage of chronic diseases; Provide exercise and diet prescriptions or suggestions for patients with chronic diseases such as diabetes, hyperlipidemia and hypertension.

　　The second is to organize the compilation of the National Guidelines for the Prevention and Control of Hypertension and the National Guidelines for the Prevention and Control of Diabetes, so as to guide local primary medical and health institutions to provide health management services for patients with chronic diseases.

　　The third is to actively promote the training of "medical prevention and management" integrated talents and establish a medical prevention and control integration mechanism. Relying on the contract service of family doctors, we will promote the combination of prevention and medical care, do a good job in health follow-up of key populations, and carry out multi-disease co-management services for patients with chronic diseases such as hypertension and type 2 diabetes, mainly through the integration of medical care and prevention.

　　Fourth, relying on the construction of county medical community, promote the establishment of division of labor and cooperation and two-way referral mechanism between primary medical and health institutions and superior medical institutions, and extend the services of superior hospitals to the grassroots. For patients with chronic diseases with stable conditions, health management services are provided by grass-roots institutions in accordance with norms and guidelines. There are some good explorations and practices in this regard in various places, for example, Tianjin promotes the construction of grass-roots chronic disease management centers, and provides residents with online and offline integrated all-round and full-cycle health services through intelligent auxiliary diagnosis, convenient chronic disease assessment, customized treatment programs and personalized health management. Relying on the construction of county medical associations and urban medical associations, Zhejiang Province has realized that the general diagnosis, treatment and daily management of "two chronic diseases" are mainly based on grass-roots medical and health institutions, realizing linkage from top to bottom and smoothing referral channels.